Expression of Adhesion Molecules in Cultured Human Nasal Mucosal Microvascular Endothelial Cells Activated by Interleukin–1â or Tumor Necrosis Factor–·: Effects of Dexamethasone

Yuji Yamamoto; Katsuhisa Ikeda; Masako Watanabe; Akira Shimomura; Hideaki Suzuki; Takeshi Oshima; Yoko Imamura; Kazuo Ohuchi; Tomonori Takasaka

doi:10.1159/000023992

journal article Jan 01, 1998

Expression of Adhesion Molecules in Cultured Human Nasal Mucosal Microvascular Endothelial Cells Activated by Interleukin–1â or Tumor Necrosis Factor–·: Effects of Dexamethasone

Katsuhisa Ikeda Masako Watanabe Akira Shimomura Hideaki Suzuki Takeshi Oshima Yoko Imamura Kazuo Ohuchi Tomonori Takasaka

International Archives of Allergy and Immunology Vol. 117 No. 1 pp. 68-77 · S. Karger AG

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Abstract

Adhesion molecules of microvascular endothelial cells play a key role in the inflammatory processes involved in nonallergic sinusitis. We investigated the cytokine–regulated expression of intercellular adhesion molecule–1 (ICAM–1), E–selectin and vascular cell adhesion molecule–1 (VCAM–1), and the effect of dexamethasone on these expressions in cultured human nasal microvascular endothelial cells (HNMEC). ICAM–1 was enhanced, and E–selectin and VCAM–1 were induced in a dose–dependent fashion following stimulation with IL–1β or TNF–α. HNMEC differed from human umbilical vein endothelila cells in that (1) maximal upregulation of ICAM–1 expression induced by IL–1β or TNF–α required more time (2) TNF–α was more potent than IL–1β in VCAM–1 expression, and (3) dexamethasone inhibited the upregulation of E–selectin expression alone. These findings contribute to a better understanding of the characteristic features of leukocyte infiltration into inflamed tissue and the effect of glucocorticoid in nonallergic chronic sinusitis.

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Details

Published: Jan 01, 1998
Vol/Issue: 117(1)
Pages: 68-77
License: View

Authors

Y

Yuji Yamamoto

Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; The Institute for Solid State Physics, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa 277-8581, Japan; NOF Corporation, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-0865, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; NEXT 21, 3-38-1 Hongo, Bunkyo-ku, Tokyo 113-0033,...

Department of Psychiatry National Center of Neurology and Psychiatry Tokyo Japan

Cite This Article

Yuji Yamamoto, Katsuhisa Ikeda, Masako Watanabe, et al. (1998). Expression of Adhesion Molecules in Cultured Human Nasal Mucosal Microvascular Endothelial Cells Activated by Interleukin–1â or Tumor Necrosis Factor–·: Effects of Dexamethasone. International Archives of Allergy and Immunology, 117(1), 68-77. https://doi.org/10.1159/000023992

Expression of Adhesion Molecules in Cultured Human Nasal Mucosal Microvascular Endothelial Cells Activated by Interleukin–1â or Tumor Necrosis Factor–·: Effects of Dexamethasone

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