Objective Assessment of the Degree of Dementia by Means of EEG

Martin Brunovsky; Milos Matousek; Ake Edman; Katerina Cervena; Vladimir Krajca

doi:10.1159/000071824

journal article Jan 01, 2003

Objective Assessment of the Degree of Dementia by Means of EEG

Martin Brunovsky Milos Matousek Ake Edman Katerina Cervena Vladimir Krajca

Neuropsychobiology Vol. 48 No. 1 pp. 19-26 · S. Karger AG

View at Publisher Save 10.1159/000071824

Abstract

The aim of the study was to elaborate a method to estimate the degree of cognitive impairment in Alzheimer’s disease from the EEG quantitative indicators. We examined 38 unmedicated patients with a diagnosis of Alzheimer’s disease, with various stages (mild, moderate, and severe) of dementia. The EEG recordings were evaluated both visually and by means of computer analysis. The EEG spectra and coherences in 6 frequency bands were calculated in 16 EEG derivations. Among various EEG indicators, a decrease in the alpha coherence and an increase in the delta coherence was found to be most significantly correlated to the degree of dementia. Combining 6 variables from the spectrum and coherence analysis by means of the multiple regression model, a high correlation (r = 0.87) between a set of EEG variables and the Mini-Mental State Examination score could be obtained. The results suggest that the EEG can supplement the clinical examination by providing an independent assessment of the degree of dementia. The results also suggest that the EEG coherences are of particular interest in dementia, being an indicator of the signal transfer between various parts of the brain cortex.

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Details

Published: Jan 01, 2003
Vol/Issue: 48(1)
Pages: 19-26
License: View

Authors

Cite This Article

Martin Brunovsky, Milos Matousek, Ake Edman, et al. (2003). Objective Assessment of the Degree of Dementia by Means of EEG. Neuropsychobiology, 48(1), 19-26. https://doi.org/10.1159/000071824

Objective Assessment of the Degree of Dementia by Means of EEG

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