Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure

Andrew R. Coggan; Joshua L. Leibowitz; Catherine Anderson Spearie; Ana Kadkhodayan; Deepak P. Thomas; Sujata Ramamurthy; Kiran Mahmood; Soo Park; Suzanne Waller; Marsha Farmer; Linda R. Peterson

doi:10.1161/circheartfailure.115.002141

journal article Sep 01, 2015

Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure

Andrew R. Coggan Joshua L. Leibowitz Catherine Anderson Spearie Ana Kadkhodayan Deepak P. Thomas Sujata Ramamurthy Kiran Mahmood Soo Park Suzanne Waller Marsha Farmer Linda R. Peterson

Circulation: Heart Failure Vol. 8 No. 5 pp. 914-920 · Ovid Technologies (Wolters Kluwer Health)

View at Publisher Save 10.1161/circheartfailure.115.002141

Abstract

Background—

Skeletal muscle strength, velocity, and power are markedly reduced in patients with heart failure, which contributes to their impaired exercise capacity and lower quality of life. This muscle dysfunction may be partially because of decreased nitric oxide (NO) bioavailability. We therefore sought to determine whether ingestion of inorganic nitrate (NO
3
−
) would increase NO production and improve muscle function in patients with heart failure because of systolic dysfunction.

Methods and Results—

Using a double-blind, placebo-controlled, randomized crossover design, we determined the effects of dietary NO
3
−
in 9 patients with heart failure. After fasting overnight, subjects drank beetroot juice containing or devoid of 11.2 mmol of NO
3
−
. Two hours later, muscle function was assessed using isokinetic dynamometry. Dietary NO
3
−
increased (
P
<0.05–0.001) breath NO by 35% to 50%. This was accompanied by 9% (
P
=0.07) and 11% (
P
<0.05) increases in peak knee extensor power at the 2 highest movement velocities tested (ie, 4.71 and 6.28 rad/s). Maximal power (calculated by fitting peak power data with a parabola) was therefore greater (ie, 4.74±0.41 versus 4.20±0.33 W/kg;
P
<0.05) after dietary NO
3
−
intake. Calculated maximal velocity of knee extension was also higher after NO
3
−
ingestion (ie, 12.48±0.95 versus 11.11±0.53 rad/s;
P
<0.05). Blood pressure was unchanged, and no adverse clinical events occurred.

Conclusions—

In this pilot study, acute dietary NO
3
−
intake was well tolerated and enhanced NO bioavailability and muscle power in patients with systolic heart failure. Larger-scale studies should be conducted to determine whether the latter translates into an improved quality of life in this population.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01682356.

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115

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References

Details

Published: Sep 01, 2015
Vol/Issue: 8(5)
Pages: 914-920

Authors

A

Andrew R. Coggan

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

J

Joshua L. Leibowitz

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

C

Catherine Anderson Spearie

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

A

Ana Kadkhodayan

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

D

Deepak P. Thomas

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

S

Sujata Ramamurthy

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

K

Kiran Mahmood

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

S

Soo Park

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

S

Suzanne Waller

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

M

Marsha Farmer

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

L

Linda R. Peterson

From the Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology (A.R.C., J.L.L., L.R.P.), Cardiovascular Division, Department of Medicine (J.L.L., A.K., D.P.T., S.R., K.M., S.P., M.F., L.R.P.), and Center for Applied Research Sciences (C.A.S.), Washington University School of Medicine, St. Louis, MO.

Cite This Article

Andrew R. Coggan, Joshua L. Leibowitz, Catherine Anderson Spearie, et al. (2015). Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure. Circulation: Heart Failure, 8(5), 914-920. https://doi.org/10.1161/circheartfailure.115.002141

Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure

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