The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow

Naoki Kiyota; Yukihiro Shiga; Kohei Ichinohasama; Masayuki Yasuda; Naoko Aizawa; Kazuko Omodaka; Naoto Honda; Hiroshi Kunikata; Toru Nakazawa

doi:10.1167/iovs.18-23872

journal article Open Access Jul 12, 2018

The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow

Naoki Kiyota Yukihiro Shiga

Kohei Ichinohasama Masayuki Yasuda Naoko Aizawa Kazuko Omodaka Naoto Honda Hiroshi Kunikata Toru Nakazawa

Investigative Opthalmology & Visual Science Vol. 59 No. 8 pp. 3488 · Association for Research in Vision and Ophthalmology (ARVO)

View at Publisher Save 10.1167/iovs.18-23872

Topics

No keywords indexed for this article. Browse by subject →

References

52

[1]

Rassam SM, Patel V, Kohner EM. The effect of experimental hypertension on retinal vascular autoregulation in humans: a mechanism for the progression of diabetic retinopathy. Exp Physiol. 1995; 80: 53–68. 10.1113/expphysiol.1995.sp003834

[2]

Pemp B, Schmetterer L. Ocular blood flow in diabetes and age-related macular degeneration. Can J Ophthalmol / J Can d'Ophtalmologie. 2008; 43: 295–301. 10.3129/i08-049

[3]

Kiyota N, Shiga Y, Suzuki S, et al. The effect of systemic hyperoxia on optic nerve head blood flow in primary open-angle glaucoma patients. 2017: 23–25. 10.1167/iovs.17-21648

[4]

Gugleta K, Kochkorov A, Waldmann N, et al. Dynamics of retinal vessel response to flicker light in glaucoma patients and ocular hypertensives. Graefe's Arch Clin Exp Ophthalmol. 2012; 250: 589–594. 10.1007/s00417-011-1842-2

[5]

Zeitz O, Mayer J, Hufnagel D, et al. Neuronal activity influences hemodynamics in the paraoptic short posterior ciliary arteries: a comparison between healthy and glaucomatous subjects. Invest Ophthalmol Vis Sci. 2009; 50: 5846–5850. 10.1167/iovs.09-3696

[6]

Guyton AC, Carrier O, Walker JR. Evidence for tissue oxygen demand as the major factor causing autoregulation. Circ Res. 1964; 15: 60–69.

[7]

Quill B, Henry E, Simon E, Brien CJO. Evaluation of the effect of hypercapnia on vascular function in normal tension glaucoma. 2015; 2015: 418159. 10.1155/2015/418159

[8]

Riva CE, Salgarello T, Logean E, Colotto A, Galan EM, Falsini B. Flicker-evoked response measured at the optic disc rim is reduced in ocular hypertension and early glaucoma. Invest Ophthalmol Vis Sci. 2004; 45: 3662–3668. 10.1167/iovs.04-0100

[9]

Shiga Y, Sato M, Maruyama K, et al. Assessment of short-term changes in optic nerve head hemodynamics in hyperoxic conditions with laser speckle flowgraphy. Curr Eye Res. 2015; 40: 1055–1062. 10.3109/02713683.2014.971934

[10]

Witkowska KJ, Bata AM, Calzetti G, et al. Optic nerve head and retinal blood flow regulation during isometric exercise as assessed with laser speckle flowgraphy. PLoS One. 2017; 12: e0184772. 10.1371/journal.pone.0184772

[11]

Shiga Y, Shimura M, Asano T, et al. The influence of posture change on ocular blood flow in normal subjects, measured by laser speckle flowgraphy. Curr Eye Res. 2013; 38: 691–698. 10.3109/02713683.2012.758292

[12]

Dumskyj MJ, Eriksen JE, Doré CJ, Kohner EM. Autoregulation in the human retinal circulation: assessment using isometric exercise, laser Doppler velocimetry, and computer-assisted image analysis. Microvasc Res. 1996; 51: 378–392. 10.1006/mvre.1996.0034

[13]

Autoregulation of Optic Nerve Head Blood Flow Induced by Elevated Intraocular Pressure during Vitreous Surgery

Ryuya Hashimoto, Tetsuya Sugiyama, Makoto Ubuka et al.

Current Eye Research 10.1080/02713683.2016.1220592

[14]

The advanced glaucoma intervention study (AGIS): 7. the relationship between control of intraocular pressure and visual field deterioration

American Journal of Ophthalmology 10.1016/s0002-9394(00)00538-9

[15]

Harris A, Joos K, Kay M, et al. Acute IOP elevation with scleral suction: effects on retrobulbar haemodynamics. Br J Ophthalmol. 1996; 80: 1055–1059. 10.1136/bjo.80.12.1055

[16]

Pillunat LE, Stodtmeister R, Wilmanns I, Christ T. Autoregulation of ocular blood flow during changes in intraocular pressure. Preliminary results. Graefes Arch Clin Exp Ophthalmol. 1985; 223: 219–223. 10.1007/bf02174065

[17]

Polska E, Simader C, Weigert G, et al. Regulation of choroidal blood flow during combined changes in intraocular pressure and arterial blood pressure. Invest Ophthalmol Vis Sci. 2007; 48: 3768–3774. 10.1167/iovs.07-0307

[18]

Weigert G, Findl O, Luksch A, et al. Effects of moderate changes in intraocular pressure on ocular hemodynamics in patients with primary open-angle glaucoma and healthy controls. Ophthalmology. 2005; 112: 1337–1342. 10.1016/j.ophtha.2005.03.016

[19]

Wang L, Burgoyne CF, Cull G, Thompson S, Fortune B. Static blood flow autoregulation in the optic nerve head in normal and experimental glaucoma. Invest Opthalmol Vis Sci. 2014; 55: 873–880. 10.1167/iovs.13-13716

[20]

Cull G, Burgoyne CF, Fortune B, Wang L. Longitudinal hemodynamic changes within the optic nerve head in experimental glaucoma. Invest Ophthalmol Vis Sci. 2013; 54: 4271–4277. 10.1167/iovs.13-12013

[21]

Petrig BL, Riva CE, Hayreh SS. Laser Doppler flowmetry and optic nerve head blood flow. Am J Ophthalmol. 1999; 127: 413–425. 10.1016/s0002-9394(98)00437-1

[22]

Langhans M, Michelson G, Groh MJM. Effect of breathing 100% oxygen on retinal and optic nerve head capillary blood flow in smokers and non-smokers. Br J Ophthalmol. 1997; 81: 365–369. 10.1136/bjo.81.5.365

[23]

Riva CE, Geiser M, Petrig BL, Beijing 100193 PCOBFRA. Ocular blood flow assessment using continuous laser Doppler flowmetry. Acta Ophthalmol. 2010; 88: 622–629. 10.1111/j.1755-3768.2009.01621.x

[24]

Luft N, Wozniak PA, Aschinger GC, et al. Measurements of retinal perfusion using laser speckle flowgraphy and doppler optical coherence tomography. Invest Ophthalmol Vis Sci. 2016; 57: 5417–5425. 10.1167/iovs.16-19896

[25]

Aizawa N, Yokoyama Y, Chiba N, et al. Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma. Clin Ophthalmol. 2011; 5: 1171–1176.

[26]

Use of laser speckle flowgraphy in ocular blood flow research

Tetsuya Sugiyama, Makoto Araie, Charles E. Riva et al.

Acta Ophthalmologica 10.1111/j.1755-3768.2009.01586.x

[27]

Omodaka K, Horii T, Takahashi S, et al. 3D evaluation of the lamina cribrosa with swept-source optical coherence tomography in normal tension glaucoma. PLoS One. 2015; 10: e0122347. 10.1371/journal.pone.0122347

[28]

Observation of Choroidal Circulation Using Index of Erythrocytic Velocity

Hiroaki ISONO

Archives of Ophthalmology 10.1001/archopht.121.2.225

[29]

Maruyama K, Noguchi A, Shimizu A, Shiga Y, Kunikata H, Nakazawa T. Predictors of recurrence in Vogt-Koyanagi-Harada disease. Ophthalmol Retina. 2018; 2: 343–350. 10.1016/j.oret.2017.07.016

[30]

Tsuda S, Kunikata H, Shimura M, et al. Pulse-waveform analysis of normal population using laser speckle flowgraphy. Curr Eye Res. 2014; 39: 1207–1215. 10.3109/02713683.2014.905608

[31]

Yanagida K, Iwase T, Yamamoto K, et al. Sex-related differences in ocular blood flow of healthy subjects using laser speckle flowgraphy. Invest Ophthalmol Vis Sci. 2015; 56: 4880–4890. 10.1167/iovs.15-16567

[32]

Saito M, Saito W, Hirooka K, et al. Pulse waveform changes in macular choroidal hemodynamics with regression of acute central serous chorioretinopathy. 2015; 56: 6515–6522. 10.1167/iovs.15-17246

[33]

Shiga Y, Omodaka K, Kunikata H, et al. Waveform analysis of ocular blood flow and the early detection of normal tension glaucoma. Invest Ophthalmol Vis Sci. 2013; 54: 7699–7706. 10.1167/iovs.13-12930

[34]

Konishi N, Tokimoto Y, Kohra K, Fujii H. New laser speckle flowgraphy system using CCD camera. Opt Rev. 2002; 9: 163–169. 10.1007/s10043-002-0163-4

[35]

Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases

Tetsuya Sugiyama

Photonics 10.3390/photonics1030220

[36]

Kiyota N, Shiga Y, Takahashi H, Nakazawa T. Large vessel area of the optic nerve head, measured with laser speckle flowgraphy, is significantly reduced in eyes with preperimetric glaucoma. Clin Experiment Ophthalmol. 2015; 43: 841–843. 10.1111/ceo.12562

[37]

Laser Speckle and Hydrogen Gas Clearance Measurements of Optic Nerve Circulation in Albino and Pigmented Rabbits With or Without Optic Disc Atrophy

N. Aizawa, F. Nitta, H. Kunikata et al.

Investigative Ophthalmology & Visual Science 10.1167/iovs.14-15373

[38]

Wang L, Cull GA, Piper C, Burgoyne CF, Fortune B. Anterior and posterior optic nerve head blood flow in nonhuman primate experimental glaucoma model measured by laser speckle imaging technique and microsphere method. Invest Ophthalmol Vis Sci. 2012; 53: 8303–8309. 10.1167/iovs.12-10911

[39]

Luft N, Wozniak PA, Aschinger GC, et al. Measurements of retinal perfusion using laser speckle flowgraphy and doppler optical coherence tomography. Invest Ophthalmol Vis Sci. 2016; 57: 5417–5425. 10.1167/iovs.16-19896

[40]

R Core Team. A Language and Environment for Statistical Computing. R Foundation for Statistical Computing. Available at: https://www.r-project.org/. Accessed March 2, 2018.

[41]

Schmidl D, Boltz A, Kaya S, et al. Role of nitric oxide in optic nerve head blood flow regulation during an experimental increase in intraocular pressure in healthy humans. Exp Eye Res. 2013; 116: 247–253. 10.1016/j.exer.2013.09.008

[42]

Kiyota N, Kunikata H, Takahashi S, Shiga Y, Omodaka K, Nakazawa T. Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal-tension glaucoma with myopic disc. Acta Ophthalmol. 2018;96: e290–e297. 10.1111/aos.13621

[43]

Yang Q, Shen J, Guo W, Wen J, Wang Z, Yu D. Effect of acute intraocular pressure elevation on blood flow velocity and resistance in the rabbit ophthalmic artery. Vet Ophthalmol. 2011; 14: 353–357. 10.1111/j.1463-5224.2011.00881.x

[44]

Delaey C, Van De Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic Res. 2000; 32: 249–256. 10.1159/000055622

[45]

Iwase T, Kobayashi M, Yamamoto K, Yanagida K, Ra E, Terasaki H. Changes in blood flow on optic nerve head after vitrectomy for rhegmatogenous retinal detachment. Invest Opthalmol Vis Sci. 2016; 57: 6223–6233. 10.1167/iovs.16-20577

[46]

Sato T, Sugawara J, Aizawa N, et al. Longitudinal changes of ocular blood flow using laser speckle flowgraphy during normal pregnancy. PLoS One. 2017; 12: 1–10. 10.1371/journal.pone.0173127

[47]

Riva CE, Hero M, Titze P, Petrig B. Autoregulation of human optic nerve head blood flow in response to acute changes in ocular perfusion pressure. Graefes Arch Clin Exp Ophthalmol. 1997; 235: 618–626. 10.1007/bf00946937

[48]

Movaffaghy A, Chamot SR, Petrig BL, Riva CE. Blood flow in the human optic nerve head during isometric exercise. Exp Eye Res. 1998; 67: 561–568. 10.1006/exer.1998.0556

[49]

Schmidl D, Boltz A, Kaya S, et al. Comparison of choroidal and optic nerve head blood flow regulation during changes in ocular perfusion pressure. Invest Ophthalmol Vis Sci. 2012; 53: 4337–4346. 10.1167/iovs.11-9055

[50]

Wang L, Cull G, Burgoyne CF, Thompson S, Fortune B. Longitudinal alterations in the dynamic autoregulation of optic nerve head blood flow revealed in experimental glaucoma. Invest Ophthalmol Vis Sci. 2014; 55: 3509–3516. 10.1167/iovs.14-14020

Showing 50 of 52 references

Metrics

37

Citations

52

References

Details

Published: Jul 12, 2018
Vol/Issue: 59(8)
Pages: 3488
License: View

Authors

N

Naoki Kiyota

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan

Y

Yukihiro Shiga

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan; Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Miyagi, Japan

K

Kohei Ichinohasama

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan

M

Masayuki Yasuda

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan

N

Naoko Aizawa

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan

K

Kazuko Omodaka

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan; Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Miyagi, Japan

N

Naoto Honda

Development Sec. 9, Medical Development Department, Eye Care Division, NIDEK Co., Ltd, Aichi, Japan

H

Hiroshi Kunikata

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Miyagi, Japan

T

Toru Nakazawa

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan; Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Miyagi, Japan; Development Sec. 9, Medical Development Department, Eye Care Division, NIDEK Co., Ltd, Aichi, Japan; Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Miyagi, Japan; Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Miyagi, Japan

Cite This Article

Naoki Kiyota, Yukihiro Shiga, Kohei Ichinohasama, et al. (2018). The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow. Investigative Opthalmology & Visual Science, 59(8), 3488. https://doi.org/10.1167/iovs.18-23872

The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow

You May Also Like