Dysregulated Arginine Metabolism Is Linked to Retinal Degeneration in Cep250 Knockout Mice

Chandra "Retinal ciliopathies through the lens of Bardet-Biedl Syndrome: past, present and future" Progr Retinal Eye Res (2022) 10.1016/j.preteyeres.2021.101035

[2]

Reiter "Genes and molecular pathways underpinning ciliopathies" Nat Rev Mol Cell Biol (2017) 10.1038/nrm.2017.60

[3]

Baehr "Insights into photoreceptor ciliogenesis revealed by animal models" Progress in Retinal and Eye Research (2019) 10.1016/j.preteyeres.2018.12.004

[4]

Downs "Overlap of abnormal photoreceptor development and progressive degeneration in Leber congenital amaurosis caused by NPHP5 mutation" Hum Mol Genet (2016) 10.1093/hmg/ddw254

[5]

Rannar "Renal-retinal ciliopathy gene Sdccag8 regulates DNA damage response signaling" J Am Soc Nephrol (2014) 10.1681/asn.2013050565

[6]

Slaats Gisela "Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition" PLoS Genet (2014) 10.1371/journal.pgen.1004594

[7]

Ronquillo "Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation" FASEB J (2016) 10.1096/fsb2.v30.10

[8]

Sharif "Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis" J Biol Chem (2021) 10.1016/j.jbc.2021.100529

[9]

Guo "Tmem138 is localized to the connecting cilium essential for rhodopsin localization and outer segment biogenesis" Proc Natl Acad Sci USA (2022) 10.1073/pnas.2109934119

[10]

Dilan "ARL13B, a Joubert syndrome–associated protein, is critical for retinogenesis and elaboration of mouse photoreceptor outer segments" J Neurosci (2019) 10.1523/jneurosci.1761-18.2018

[11]

Mookherjee "A CEP290 C-Terminal domain complements the mutant CEP290 of Rd16 mice in trans and rescues retinal degeneration" Cell Reports (2018) 10.1016/j.celrep.2018.09.043

[12]

Cheng "Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies" Proc Natl Acad Sci USA (2020) 10.1073/pnas.2000339117

[13]

Grenell "Loss of MPC1 reprograms retinal metabolism to impair visual function" Proc Natl Acad Sci USA (2019) 10.1073/pnas.1812941116

[14]

SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration

Yo Sasaki, Hiroki Kakita, Shunsuke Kubota et al.

eLife 2020 10.7554/elife.62027

[15]

Sinha "Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration" Proc Natl Acad Sci USA (2021) 10.1073/pnas.2018956118

[16]

Xiang "miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance" Proc Natl Acad Sci USA (2017) 10.1073/pnas.1618757114

[17]

Xu "Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium" Proc Natl Acad Sci USA (2018) 10.1073/pnas.1802724115

[18]

Masek "Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition" Nat Commun (2022) 10.1038/s41467-022-28982-6

[19]

Do Rhee "Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas" Nat Commun (2022) 10.1038/s41467-022-34443-x

[20]

Lains "Plasma metabolomic profiles associated with three-year progression of age-related macular degeneration" Metabolites (2022) 10.3390/metabo12010032

[21]

Wang "Serum untargeted metabolomics reveal potential biomarkers of progression of diabetic retinopathy in Asians" Front Mol Biosci (2022) 10.3389/fmolb.2022.871291

[22]

Zhou "Plasma metabolites in treatment-requiring retinopathy of prematurity: potential biomarkers identified by metabolomics" Exp Eye Res (2020) 10.1016/j.exer.2020.108198

[23]

Weiss "Broad spectrum metabolomics for detection of abnormal metabolic pathways in a mouse model for retinitis pigmentosa" Exp Eye Res (2019) 10.1016/j.exer.2019.03.007

[24]

Hou "Metabolomics and biomarkers in retinal and choroidal vascular diseases" Metabolites (2022) 10.3390/metabo12090814

[25]

Laíns "Metabolomics in the study of retinal health and disease" Prog Retin Eye Res (2019) 10.1016/j.preteyeres.2018.11.002

[26]

Zhang "Ablation of mature miR-183 leads to retinal dysfunction in mice" Invest Ophthalmol Vis Sci (2020) 10.1167/iovs.61.3.12

[27]

Zhuang "Slc7a14 Is indispensable in zebrafish retinas" Front Cell Dev Biol (2019) 10.3389/fcell.2019.00333

[28]

Xiang "Depletion of miR-96 delays, but does not arrest, photoreceptor development in mice" Invest Ophthalmol Vis Sci (2022) 10.1167/iovs.63.4.24

[29]

Santucci "Development of a novel ultra performance liquid chromatography tandem-mass spectrometry (UPLC-MS/MS) method to measure l-arginine metabolites in plasma" Clin Chim Acta (2023) 10.1016/j.cca.2023.117306

[30]

Mercey "The connecting cilium inner scaffold provides a structural foundation that protects against retinal degeneration" PLoS Biol (2022) 10.1371/journal.pbio.3001649

[31]

Boldt "Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice" J Clin Invest (2011) 10.1172/jci45627

[32]

Gotthardt "A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins" eLife (2015) 10.7554/elife.11859

[33]

Hsu "Light regulates the ciliary protein transport and outer segment disc renewal of mammalian photoreceptors" Dev Cell (2015) 10.1016/j.devcel.2015.01.027

[34]

Pearring "The GARP domain of the rod CNG channel's ß1-subunit contains distinct sites for outer segment targeting and connecting to the photoreceptor disk rim" J Neurosci (2021) 10.1523/jneurosci.2609-20.2021

[35]

Fang "Identification of additional outer segment targeting signals in zebrafish rod opsin" J Cell Sci (2021) 10.1242/jcs.254995

[36]

Pearring "Protein sorting, targeting and trafficking in photoreceptor cells" Prog Retin Eye Res (2013) 10.1016/j.preteyeres.2013.03.002

[37]

Vinberg "Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors" Prog Retin Eye Res (2018) 10.1016/j.preteyeres.2018.06.001

[38]

Peshenko "Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase" J Biol Chem (2021) 10.1016/j.jbc.2021.101201

[39]

Hannemann "Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis" J Clin Invest (2019) 10.1172/jci96832

[40]

Pesce "Arginase-1–expressing macrophages suppress Th2 cytokine–driven inflammation and fibrosis" PLoS Pathog (2009) 10.1371/journal.ppat.1000371

[41]

Monin "Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis" J Clin Invest (2015) 10.1172/jci77378

[42]

Mondanelli "The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO" Curr Opin Pharmacol (2017) 10.1016/j.coph.2017.05.002

[43]

Munder "L-Arginine deprivation impairs Leishmania major–specific T-cell responses: immunity to infection" Eur J Immunol (2009) 10.1002/eji.200839041

[44]

Kropf "Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo" FASEB J (2005) 10.1096/fsb2.v19.8

[45]

Rutschman "Cutting edge: stat6-dependent substrate depletion regulates nitric oxide production" J Immunol (2001) 10.4049/jimmunol.166.4.2173

[46]

Schleicher "TNF-mediated restriction of arginase 1 expression in myeloid cells triggers type 2 NO synthase activity at the site of infection" Cell Rep (2016) 10.1016/j.celrep.2016.04.001

[47]

Garces "Increased neuroprotective microglia and photoreceptor survival in the retina from a peptide inhibitor of myeloid differentiation factor 88 (MyD88)" J Mol Neurosci (2020) 10.1007/s12031-020-01503-0

[48]

Mages "The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia" J Neuroinflammation (2019) 10.1186/s12974-019-1424-5

[49]

Heng "Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution" Proc Natl Acad Sci USA (2019) 10.1073/pnas.1821122116

[50]

Sumarriva "Arginine and carnitine metabolites are altered in diabetic retinopathy" Invest Ophthalmol Vis Sci (2019) 10.1167/iovs.19-27321

Showing 50 of 54 references

Metrics

10

Citations

54

References

Details

Published: Sep 01, 2023
Vol/Issue: 64(12)
Pages: 2
License: View

Authors

L

Long Xiang