Extravascular Motion Signal Detected by OCT Angiography Indicates Altered Vascular-Tissue Biomechanical Interactions in Glaucoma

Arwa Arrashoud; Juan Reynaud; Michaela Dunn; Grant Cull; Stuart K. Gardiner; BRAD FORTUNE

doi:10.1167/iovs.67.4.10

journal article Open Access Apr 06, 2026

Extravascular Motion Signal Detected by OCT Angiography Indicates Altered Vascular-Tissue Biomechanical Interactions in Glaucoma

Arwa Arrashoud Juan Reynaud Michaela Dunn Grant Cull Stuart K. Gardiner BRAD FORTUNE

Investigative Opthalmology & Visual Science Vol. 67 No. 4 pp. 10 · Association for Research in Vision and Ophthalmology (ARVO)

View at Publisher Save 10.1167/iovs.67.4.10

Topics

No keywords indexed for this article. Browse by subject →

References

41

[1]

Tatham "Detecting structural progression in glaucoma with optical coherence tomography" Ophthalmology (2017) 10.1016/j.ophtha.2017.07.015

[2]

Mohammadzadeh "Macular imaging with optical coherence tomography in glaucoma" Surv Ophthalmol (2020) 10.1016/j.survophthal.2020.03.002

[3]

Geevarghese "Optical coherence tomography and glaucoma" Annu Rev Vis Sci (2021) 10.1146/annurev-vision-100419-111350

[4]

Gao "Optical coherence tomography angiography" Invest Ophthalmol Vis Sci (2016) 10.1167/iovs.15-19043

[5]

Chen "Optical coherence tomography based angiography [Invited]" Biomed Opt Express (2017) 10.1364/boe.8.001056

[6]

Kashani "Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications" Prog Retin Eye Res (2017) 10.1016/j.preteyeres.2017.07.002

[7]

Optical coherence tomography angiography

Richard F. Spaide, James G. Fujimoto, Nadia K. Waheed et al.

Progress in Retinal and Eye Research 2018 10.1016/j.preteyeres.2017.11.003

[8]

Chansangpetch "Optical coherence tomography angiography in glaucoma care" Curr Eye Res (2018)

[9]

Fortune "Optical coherence tomography evaluation of the optic nerve head neuro-retinal rim in glaucoma" Clin Exp Optom (2019) 10.1111/cxo.12833

[10]

Shiga "Optical coherence tomography and optical coherence tomography angiography: essential tools for detecting glaucoma and disease progression" Front Ophthalmol (Lausanne) (2023) 10.3389/fopht.2023.1217125

[11]

WuDunn "OCT angiography for the diagnosis of glaucoma: a report by the American Academy of Ophthalmology" Ophthalmology (2021) 10.1016/j.ophtha.2020.12.027

[12]

Rao "Optical Coherence tomography angiography in glaucoma" J Glaucoma (2020) 10.1097/ijg.0000000000001463

[13]

Bowd "Gradient-boosting classifiers combining vessel density and tissue thickness measurements for classifying early to moderate glaucoma" Am J Ophthalmol (2020) 10.1016/j.ajo.2020.03.024

[14]

Hou "Macular thickness and microvasculature loss in glaucoma suspect eyes" Ophthalmol Glaucoma (2022) 10.1016/j.ogla.2021.07.009

[15]

Spaide "Image artifacts in optical coherence tomography angiography" Retina (2015) 10.1097/iae.0000000000000765

[16]

Enders "Quantity and quality of image artifacts in optical coherence tomography angiography" PLoS One (2019) 10.1371/journal.pone.0210505

[17]

Hormel "Artifacts and artifact removal in optical coherence tomographic angiography" Quant Imaging Med Surg (2021) 10.21037/qims-20-730

[18]

Artifacts in Optical Coherence Tomography Angiography

Pasha Anvari, Maryam Ashrafkhorasani, Abbas Habibi et al.

Journal of Ophthalmic and Vision Research 2021 10.18502/jovr.v16i2.9091

[19]

Kamalipour "OCT angiography artifacts in glaucoma" Ophthalmology (2021) 10.1016/j.ophtha.2021.03.036

[20]

Cheng "Assessment of artifacts in swept-source optical coherence tomography angiography for glaucomatous and normal eyes" Transl Vis Sci Technol (2022) 10.1167/tvst.11.1.23

[21]

Fortune "Experimental glaucoma causes optic nerve head neural rim tissue compression: a potentially important mechanism of axon injury" Invest Ophthalmol Vis Sci (2016) 10.1167/iovs.16-20000

[22]

Gardiner "Changes in vascular resistance with intraocular pressure and damage severity in experimental glaucoma" Exp Eye Res (2025) 10.1016/j.exer.2025.110271

[23]

Jasien "Effect of anesthesia on intraocular pressure measured with continuous wireless telemetry in nonhuman primates" Invest Ophthalmol Vis Sci (2019) 10.1167/iovs.19-27758

[24]

Gardiner "A method to estimate the amount of neuroretinal rim tissue in glaucoma: comparison with current methods for measuring rim area" Am J Ophthalmol (2014) 10.1016/j.ajo.2013.11.007

[25]

Fortune "Comparing optic nerve head rim width, rim area, and peripapillary retinal nerve fiber layer thickness to axon count in experimental glaucoma" Invest Ophthalmol Vis Sci (2016) 10.1167/iovs.15-18667

[26]

Use of laser speckle flowgraphy in ocular blood flow research

Tetsuya Sugiyama, Makoto Araie, Charles E. Riva et al.

Acta Ophthalmologica 2010 10.1111/j.1755-3768.2009.01586.x

[27]

Cull "Longitudinal hemodynamic changes within the optic nerve head in experimental glaucoma" Invest Ophthalmol Vis Sci (2013) 10.1167/iovs.13-12013

[28]

Nagahara "In vivo measurement of blood velocity in human major retinal vessels using the laser speckle method" Invest Ophthalmol Vis Sci (2011) 10.1167/iovs.09-4422

[29]

Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases

Tetsuya Sugiyama

Photonics 2014 10.3390/photonics1030220

[30]

Wang "Anterior and posterior optic nerve head blood flow in nonhuman primate experimental glaucoma model measured by laser speckle imaging technique and microsphere method" Invest Ophthalmol Vis Sci (2012) 10.1167/iovs.12-10911

[31]

Tomita "Elevated retinal artery vascular resistance determined by novel visualized technique of laser speckle flowgraphy in branch retinal vein occlusion" Sci Rep (2021) 10.1038/s41598-021-99572-7

[32]

Gardiner "Retinal vessel pulsatile characteristics associated with vascular stiffness can predict the rate of functional progression in glaucoma suspects" Invest Ophthalmol Vis Sci (2023) 10.1167/iovs.64.7.30

[33]

Gardiner "Relations between pulsatility in the optic nerve head or peripapillary retinal vessels and the rate of progression in glaucoma" Invest Ophthalmol Vis Sci (2025) 10.1167/iovs.66.12.34

[34]

Solano "Mapping pulsatile optic nerve head deformation using OCT" Ophthalmol Sci (2022) 10.1016/j.xops.2022.100205

[35]

de Kinkelder "Heartbeat-induced axial motion artifacts in optical coherence tomography measurements of the retina" Invest Ophthalmol Vis Sci (2011) 10.1167/iovs.10-6738

[36]

Kashani "Suspended scattering particles in motion: a novel feature of oct angiography in exudative maculopathies" Ophthalmol Retina (2018) 10.1016/j.oret.2017.11.004

[37]

Moret "Visualization of fundus vessel pulsation using principal component analysis" Invest Ophthalmol Vis Sci (2011) 10.1167/iovs.10-6806

[38]

Gardiner "Increased optic nerve head capillary blood flow in early primary open-angle glaucoma" Invest Ophthalmol Vis Sci (2019) 10.1167/iovs.19-27389

[39]

Yang "Differences in systemic pulse waveform between individuals with glaucoma, glaucoma suspects, and healthy controls" Invest Ophthalmol Vis Sci (2024) 10.1167/iovs.65.8.20

[40]

Morgan "Retinal venous pulsation: expanding our understanding and use of this enigmatic phenomenon" Prog Retin Eye Res (2016) 10.1016/j.preteyeres.2016.06.003

[41]

Wartak "Investigating spontaneous retinal venous pulsation using Doppler optical coherence tomography" Sci Rep (2019) 10.1038/s41598-019-40961-4

Metrics

0

Citations

41

References

Details

Published: Apr 06, 2026
Vol/Issue: 67(4)
Pages: 10
License: View

Authors

A

Arwa Arrashoud