Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

Jau-Yi Li; Benoit Chassaing; Abdul Malik Tyagi; Chiara Vaccaro; Tao Luo; Jonathan Adams; Trevor M. Darby; M. Neale Weitzmann; Jennifer G. Mulle; Andrew T. Gewirtz; Rheinallt M. Jones; Roberto Pacifici

doi:10.1172/jci86062

journal article Apr 25, 2016

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

Jau-Yi Li Benoit Chassaing

Abdul Malik Tyagi Chiara Vaccaro Tao Luo

Jonathan Adams

Trevor M. Darby M. Neale Weitzmann Jennifer G. Mulle

Andrew T. Gewirtz Rheinallt M. Jones Roberto Pacifici

Journal of Clinical Investigation Vol. 126 No. 6 pp. 2049-2063 · American Society for Clinical Investigation

View at Publisher Save 10.1172/jci86062

Topics

No keywords indexed for this article. Browse by subject →

References

105

[1]

The gut microbiota — masters of host development and physiology

Felix Sommer, Fredrik Bäckhed

Nature Reviews Microbiology 10.1038/nrmicro2974

[2]

Functional interactions between the gut microbiota and host metabolism

Valentina Tremaroli, Fredrik Bäckhed

Nature 10.1038/nature11552

[3]

10.1172/jci72332

[4]

10.1016/j.celrep.2015.07.042

[5]

10.1038/emboj.2013.224

[6]

10.1038/mi.2013.84

[7]

Lee "Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis" Proc Natl Acad Sci U S A (2011) 10.1073/pnas.1000082107

[8]

10.1128/iai.73.1.30-38.2005

[9]

10.1016/j.immuni.2010.06.001

[10]

The gut microbiota regulates bone mass in mice

Klara Sjögren, Cecilia Engdahl, Petra Henning et al.

Journal of Bone and Mineral Research 10.1002/jbmr.1588

[11]

10.1038/nature11400

[12]

10.1007/s00223-004-0097-x

[13]

10.1021/jf2013716

[14]

10.1371/journal.pone.0092368

[15]

Probiotic L. reuteri Treatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model

Robert A. Britton, Regina Irwin, Darin Quach et al.

Journal of Cellular Physiology 10.1002/jcp.24636

[16]

10.1038/nm1593

[17]

10.1016/0002-9343(83)90860-4

[18]

10.1056/nejm198606263142605

[19]

10.1677/joe.0.1380115

[20]

10.1677/joe.0.1650467

[21]

10.1172/jci28550

[22]

10.1016/j.cell.2006.01.051

[23]

10.1016/j.cell.2007.07.025

[24]

10.1038/sj.emboj.7601984

[25]

Role of T cells in ovariectomy induced bone loss—revisited

Roberto Pacifici

Journal of Bone and Mineral Research 10.1002/jbmr.1500

[26]

Khosla "Estrogen deficiency, postmenopausal osteoporosis, and age-related bone loss. In: Marcus R, Feldman D, Dempster DW, Luckey M, Cauley JA, eds" (2013) 10.1016/b978-0-12-415853-5.00046-7

[27]

10.1172/jci17215

[28]

Estradiol rapidly inhibits osteoclastogenesis and RANKL expression in bone marrow cultures in postmenopausal women: a pilot study

P. Taxel, H. Kaneko, S.-K. Lee et al.

Osteoporosis International 10.1007/s00198-007-0452-7

[29]

10.1038/nm.2448

[30]

10.1016/j.bone.2008.02.017

[31]

Adeel "Bone loss in surgically ovariectomized premenopausal women is associated with T lymphocyte activation and thymic hypertrophy" J Investig Med (2013) 10.2310/jim.0000000000000016

[32]

10.1073/pnas.86.7.2398

[33]

10.1073/pnas.88.12.5134

[34]

Cohen-Solal "Peripheral monocyte culture supernatants of menopausal women can induce bone resorption: involvement of cytokines" J Clin Endocrinol Metab (1993)

[35]

10.1007/s001980170054

[36]

10.1359/jbmr.070207

[37]

10.1073/pnas.251534698

[38]

10.1172/jci119333

[39]

10.1359/jbmr.1997.12.6.935

[40]

10.1172/jci11066

[41]

10.1172/jci11176

[42]

10.1016/j.cmet.2015.09.012

[43]

10.1186/ar3431

[44]

10.1186/ar3824

[45]

10.1084/jem.20061775

[46]

10.1056/nejmra0707449

[47]

Basu "The Th17 family: flexibility follows function" Immunol Rev (2013) 10.1111/imr.12035

[48]

10.1016/b978-0-12-394299-9.00002-3

[49]

10.1002/eji.201141938

[50]

IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages

Dragan V Jovanovic, John A Di Battista, Johanne Martel-Pelletier et al.

The Journal of Immunology 1998 10.4049/jimmunol.160.7.3513

Showing 50 of 105 references

Cited By

566

Human breastmilk-derived Bifidobacterium longum subsp. infantis CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway

Mengfan Ding, Bowen Li · 2023

Gut Microbes

Advances in pathogenesis and therapeutic strategies for osteoporosis

Shasha Song, Yuanyuan Guo · 2022

Pharmacology & Therapeutics

Temporal and regional intestinal changes in permeability, tight junction, and cytokine gene expression following ovariectomy-induced estrogen deficiency

Fraser L. Collins, Naiomy D. Rios-Arce · 2017

Physiological Reports

Physiological and pathophysiological bone turnover — role of the immune system

M. Neale Weitzmann, Ighovwerha Ofotokun · 2016

Nature Reviews Endocrinology

Metrics

566

Citations

105

References

Details

Published: Apr 25, 2016
Vol/Issue: 126(6)
Pages: 2049-2063

Authors

Cite This Article

Jau-Yi Li, Benoit Chassaing, Abdul Malik Tyagi, et al. (2016). Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics. Journal of Clinical Investigation, 126(6), 2049-2063. https://doi.org/10.1172/jci86062

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

You May Also Like