Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura

Marianne Lindblad; Anders Hougaard; Faisal Mohammad Amin; Messoud Ashina

doi:10.1177/0333102416636097

journal article Sep 29, 2016

Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura

Marianne Lindblad Anders Hougaard Faisal Mohammad Amin Messoud Ashina

Cephalalgia Vol. 37 No. 1 pp. 74-88 · SAGE Publications

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Abstract

Background The nature of the migraine aura and its role in migraine pathophysiology is incompletely understood. In particular, the mechanisms underlying aura initiation and the causal relation between aura and headache are unknown. The scientific investigation of aura in patients is only possible if aura can be triggered. This paper reviews potential methods for the experimental provocation of migraine aura. Methods We systematically searched PubMed for studies of experimental migraine provocation, including case reports of patients with aura and reports of the occurrence of aura following exposure to any kind of suspected trigger. Results We identified 21 provocation studies, using 13 different prospective provocation methods, and 34 case reports. In the prospective studies, aura were reported following the administration of intravenous and sublingual glyceryl trinitrate, visual stimulation, physical activity, calcitonin gene-related peptide infusion, chocolate ingestion, and the intravenous injection of insulin. In addition, carotid artery puncture has consistently been reported as a trigger of aura. Conclusions No safe and efficient method for aura provocation exists at present, but several approaches could prove useful for this purpose.

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Details

Published: Sep 29, 2016
Vol/Issue: 37(1)
Pages: 74-88
License: View

Authors

M

Marianne Lindblad

Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

A

Anders Hougaard

Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

F

Faisal Mohammad Amin

Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

M

Messoud Ashina

Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

Cite This Article

Marianne Lindblad, Anders Hougaard, Faisal Mohammad Amin, et al. (2016). Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura. Cephalalgia, 37(1), 74-88. https://doi.org/10.1177/0333102416636097

Can migraine aura be provoked experimentally? A systematic review of potential methods for the provocation of migraine aura

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