Primary Gastrointestinal Iatrogenic Kaposi Sarcoma: A Rare Pediatric Case Report

Nil Urganci; Ayse Mine Onenerk Men; Nuray Kepil; Rahsan Ozcan; Nil Comunoglu

doi:10.1177/10935266251345690

journal article Jun 14, 2025

Primary Gastrointestinal Iatrogenic Kaposi Sarcoma: A Rare Pediatric Case Report

Nil Urganci

Ayse Mine Onenerk Men Nuray Kepil Rahsan Ozcan

Nil Comunoglu

Pediatric and Developmental Pathology Vol. 28 No. 5 pp. 425-428 · SAGE Publications

View at Publisher Save 10.1177/10935266251345690

Abstract

Kaposi sarcoma (KS) is a rare, human herpesvirus-8 (HHV-8)-associated vascular tumor that primarily affects the skin but can involve visceral organs, particularly in immunosuppressed patients. While iatrogenic KS is well-documented in adults, isolated gastrointestinal involvement in pediatric cases remains unreported. We describe a 16-year-old HIV-negative male with chronic granulomatous disease (CGD) who initially presented with inflammatory bowel disease-like symptoms and was treated with immunosuppressive therapy. Over 17 months, he developed recurrent infections, hepatosplenomegaly, and ultimately intestinal perforation, necessitating emergency colectomy. Histopathology confirmed iatrogenic KS, highlighting the need for increased awareness of this rare malignancy in immunocompromised pediatric patients and carefully balancing the risks of long-term immunosuppressive therapy.

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Details

Published: Jun 14, 2025
Vol/Issue: 28(5)
Pages: 425-428
License: View

Authors

N

Nil Urganci

Department of Pathology, Istanbul University Cerrahpasa-Cerrahpasa Faculty of Medicine, Istanbul, Turkey

A

Ayse Mine Onenerk Men

Department of Pathology, Istanbul University Cerrahpasa-Cerrahpasa Faculty of Medicine, Istanbul, Turkey

N

Nuray Kepil

Department of Pathology, Istanbul University Cerrahpasa-Cerrahpasa Faculty of Medicine, Istanbul, Turkey

R

Rahsan Ozcan

Department of Pediatric Surgery, Istanbul University Cerrahpasa-Cerrahpasa Faculty of Medicine, Istanbul, Turkey

N

Nil Comunoglu

Department of Pathology, Istanbul University Cerrahpasa-Cerrahpasa Faculty of Medicine, Istanbul, Turkey

Cite This Article

Nil Urganci, Ayse Mine Onenerk Men, Nuray Kepil, et al. (2025). Primary Gastrointestinal Iatrogenic Kaposi Sarcoma: A Rare Pediatric Case Report. Pediatric and Developmental Pathology, 28(5), 425-428. https://doi.org/10.1177/10935266251345690

Primary Gastrointestinal Iatrogenic Kaposi Sarcoma: A Rare Pediatric Case Report

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