Osteosarcopenia and Long-COVID: a dangerous combination

Umberto Tarantino; Virginia V. Visconti; Roberto Bonanni; Andrea Gatti; Martina Marcozzi; Davide Calabrò; Ida Cariati

doi:10.1177/1759720x221130485

journal article Open Access Jan 01, 2022

Osteosarcopenia and Long-COVID: a dangerous combination

Umberto Tarantino Virginia V. Visconti Roberto Bonanni

Andrea Gatti Martina Marcozzi Davide Calabrò Ida Cariati

Therapeutic Advances in Musculoskeletal Disease Vol. 14 · SAGE Publications

View at Publisher Save 10.1177/1759720x221130485

Abstract

SARS-CoV-2 has caused a global pandemic and an unprecedented public health crisis, infecting more than 580 million people worldwide. Moreover, recent evidence has suggested the emergence of a new syndrome known as Long-COVID, a term used to describe a diverse set of physical and mental symptoms that persist after a diagnosed SARS-CoV-2 infection. Epidemiological data have identified myalgias, muscle and joint dysfunction, and bone fragility as common sequelae in patients with moderate and severe forms of this disease. Significant musculoskeletal dysfunction has also been detected in some healed patients, although knowledge about pathophysiological mechanisms of Long-COVID is still rather scarce. In this context, SARS-CoV-2 infection has been suggested to amplify the effects of aging on the musculoskeletal system by aggravating the osteosarcopenic state. Based on this evidence, our review focused on the muscle and bone tissue alterations induced by SARS-CoV-2 infection and Long-COVID, summarizing the current knowledge on the underlying biological mechanisms and highlighting the need for a multidisciplinary approach to predict the musculoskeletal targets and long-term consequences of COVID-19 disease.

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Published: Jan 01, 2022
Vol/Issue: 14
License: View

Authors

U

Umberto Tarantino

Department of Clinical Sciences and Translational Medicine, University of Rome ‘Tor Vergata’, Rome, Italy; Department of Orthopaedics and Traumatology, ‘Policlinico Tor Vergata’ Foundation, Rome, Italy

V

Virginia V. Visconti

Department of Clinical Sciences and Translational Medicine, University of Rome ‘Tor Vergata’, Rome, Italy

R

Roberto Bonanni

Department of Clinical Sciences and Translational Medicine, University of Rome ‘Tor Vergata’, Rome, Italy

A

Andrea Gatti

Department of Orthopaedics and Traumatology, ‘Policlinico Tor Vergata’ Foundation, Rome, Italy

M

Martina Marcozzi

Department of Orthopaedics and Traumatology, ‘Policlinico Tor Vergata’ Foundation, Rome, Italy

D

Davide Calabrò

Department of Orthopaedics and Traumatology, ‘Policlinico Tor Vergata’ Foundation, Rome, Italy

I

Ida Cariati

Department of Clinical Sciences and Translational Medicine, University of Rome ‘Tor Vergata’, Via Montpellier 1, 00133 Rome, Italy

Cite This Article

Umberto Tarantino, Virginia V. Visconti, Roberto Bonanni, et al. (2022). Osteosarcopenia and Long-COVID: a dangerous combination. Therapeutic Advances in Musculoskeletal Disease, 14. https://doi.org/10.1177/1759720x221130485

Osteosarcopenia and Long-COVID: a dangerous combination

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