Total Knee Replacement as a Knee Osteoarthritis Outcome

Jean-Pierre Raynauld; Johanne Martel-Pelletier; Marc Dorais; Boulos Haraoui; Denis Choquette; François Abram; Andre Beaulieu; Louis Bessette; Frédéric Morin; Lukas M. Wildi; Jean-Pierre Pelletier

doi:10.1177/1947603513483547

journal article Apr 10, 2013

Total Knee Replacement as a Knee Osteoarthritis Outcome

Jean-Pierre Raynauld Johanne Martel-Pelletier

Marc Dorais Boulos Haraoui Denis Choquette François Abram Andre Beaulieu Louis Bessette Frédéric Morin Lukas M. Wildi Jean-Pierre Pelletier

CARTILAGE Vol. 4 No. 3 pp. 219-226 · SAGE Publications

View at Publisher Save 10.1177/1947603513483547

Abstract

Objective To predict, using clinical and qMRI data, the incidence of total knee replacement (TKR) during the long-term follow-up of knee osteoarthritis (OA) patients who formerly received chondroitin sulfate (CS) or placebo treatment. Design A post hoc intention-to-treat analysis to evaluate the incidence of TKR was done on knee OA patients who had participated in a 12-month trial evaluating the impact of CS (800 mg/d) versus placebo for 6 months, followed by a 6-month open-phase in which all patients received CS. Additionally, the clinical and qMRI predictors of TKR were determined. Results Thirteen TKRs were performed in the population after a 4-year follow-up. More TKRs were performed in the placebo group than in the CS group (69% vs. 31%, P = 0.150, logistic regression). The statistically significant predictors of TKRs were, at baseline, higher WOMAC pain and function scores, presence of bone marrow lesions (BMLs), and higher C-reactive protein levels. Loss of medial cartilage volume and increase in WOMAC pain and function at one-year were also predictors of TKR. Multivariate analyses revealed that baseline presence of BML and higher WOMAC pain score were independent predictors. Time to occurrence of the TKR also favored the CS group versus placebo (log-rank, P = 0.094). Conclusion Symptoms such as knee pain and function, presence of BML, and cartilage volume loss predict the long-term occurrence of a “hard” outcome such as TKR.

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Cited By

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Chondroitin for osteoarthritis

Jasvinder A Singh, Shahrzad Noorbaloochi · 2015

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Metrics

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Citations

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References

Details

Published: Apr 10, 2013
Vol/Issue: 4(3)
Pages: 219-226
License: View

Authors

J

Jean-Pierre Raynauld

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada

J

Johanne Martel-Pelletier

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada

M

Marc Dorais

StatSciences Inc., Notre-Dame de l’Île-Perrot, Quebec, Canada

B

Boulos Haraoui

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada

D

Denis Choquette

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada

F

François Abram

Imaging Research & Development, ArthroLab Inc., Montreal, Quebec, Canada

A

Andre Beaulieu

Faculty of Medicine, Laval University, Quebec City, Quebec, Canada

L

Louis Bessette

Groupe de Recherche en Rhumatologie et Maladies Osseuses, Sainte-Foy, Quebec, Canada

F

Frédéric Morin

Centre de Recherche Musculo-squelettique, Trois-Rivières, Quebec, Canada

L

Lukas M. Wildi

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada

J

Jean-Pierre Pelletier

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada

Cite This Article

Jean-Pierre Raynauld, Johanne Martel-Pelletier, Marc Dorais, et al. (2013). Total Knee Replacement as a Knee Osteoarthritis Outcome. CARTILAGE, 4(3), 219-226. https://doi.org/10.1177/1947603513483547

Total Knee Replacement as a Knee Osteoarthritis Outcome

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