Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

Luise Erpenbeck; Michael P. Schön

doi:10.1182/blood-2009-10-247296

journal article Apr 29, 2010

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

Luise Erpenbeck Michael P. Schön

Blood Vol. 115 No. 17 pp. 3427-3436 · American Society of Hematology

View at Publisher Save 10.1182/blood-2009-10-247296

Abstract

Abstract
The general notion that functional platelets are important for successful hematogenous tumor metastasis has been inaugurated more than 4 decades ago and has since been corroborated in numerous experimental settings. Thorough preclinical investigations have, at least in part, clarified some specifics regarding the involvement of platelet adhesion receptors, such as thrombin receptors or integrins, in the metastasis cascade. Pivotal preclinical experiments have demonstrated that hematogenous tumor spread was dramatically diminished when platelets were depleted from the circulation or when functions of platelet surface receptors were inhibited pharmacologically or genetically. Such insight has inspired researchers to devise novel antitumoral therapies based on targeting platelet receptors. However, several mechanistic aspects underlying the impact of platelet receptors on tumor metastasis are not fully understood, and agents directed against platelet receptors have not yet found their way into the clinic. In addition, recent results suggesting that targeted inhibition of certain platelet surface receptors may even result in enhanced experimental tumor metastasis have demonstrated vividly that the role of platelets in tumor metastasis is more complex than has been anticipated previously. This review gives a comprehensive overview on the most important platelet receptors and their putative involvement in hematogenous metastasis of malignant tumors.

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Details

Published: Apr 29, 2010
Vol/Issue: 115(17)
Pages: 3427-3436

Authors

L

Luise Erpenbeck

Department of Dermatology, Venereology and Allergology, Georg August University, Göttingen, Germany

M

Michael P. Schön

Department of Dermatology, Venereology and Allergology, Georg August University, Göttingen, Germany

Cite This Article

Luise Erpenbeck, Michael P. Schön (2010). Deadly allies: the fatal interplay between platelets and metastasizing cancer cells. Blood, 115(17), 3427-3436. https://doi.org/10.1182/blood-2009-10-247296

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

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