Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells

Olga L Miakotina; Kelli L Goss; Jeanne M Snyder

doi:10.1186/rr191

journal article Oct 23, 2002

Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells

Olga L Miakotina Kelli L Goss Jeanne M Snyder

Respiratory Research Vol. 3 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1186/rr191

Topics

No keywords indexed for this article. Browse by subject →

References

31

[1]

Snyder JM, George TN, Miakotina OL: Insulin and lung development. In Contemporary Endocrinology: Endocrinology of the lung: Development and surfactant synthesis. (Edited by: Mendelson CR). Totowa, NY: Humana Press Inc. 2000, 181–200.

[2]

Avery ME, Mead J: Surface properties in relation to aletectasis and hyaline membrane disease. Am J Dis Child 1959, 97:517–523.

[3]

Robert MF, Neff RK, Hubbell JP, Taeusch HW, Avery ME: Association between maternal diabetes and the respiratory-distress syndrome in the newborn. N Engl J Med 1976, 294:357–360. 10.1056/nejm197602122940702

[4]

Weaver TE, Whitsett JA: Function and regulation of expression of pulmonary surfactant-associated proteins. Biochem J 1991, 273:249–264. 10.1042/bj2730249

[5]

Pryhuber GS, Hull WM, Fink I, McMahan MJ, Whitsett JA: Ontogeny of surfactant proteins A and B in human amniotic fluid as indices of fetal lung maturity. Pediatr Res 1991, 30:597–605. 10.1203/00006450-199112000-00023

[6]

Dekowski SA, Snyder JM: Insulin regulation of messenger ribonucleic acid for the surfactant-associated proteins in human fetal lung in vitro. Endocrinology 1992, 131:669–676.

[7]

Miakotina OL, Dekowski SA, Snyder JM: Insulin inhibits surfactant protein A and B gene expression in the H441 cell line. Biochim Biophys Acta 1998, 1442:60–70. 10.1016/s0167-4781(98)00121-3

[8]

Myers MG Jr, White MF: Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol 1996, 36:615–658. 10.1146/annurev.pa.36.040196.003151

[9]

Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR: A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A 1995, 92:7686–7689. 10.1073/pnas.92.17.7686

[10]

Shepherd PR, Withers DJ, Siddle K: Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998, 333:471–490. 10.1042/bj3330471

[11]

Arcaro A, Wymann MP: Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 1993, 296:297–301. 10.1042/bj2960297

[12]

Vlahos CJ, Matter WF, Hui KY, Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 1994, 269:5241–5248. 10.1016/s0021-9258(17)37680-9

[13]

Chung J, Kuo CJ, Crabtree GR, Blenis J: Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 1992, 69:1227–1236. 10.1016/0092-8674(92)90643-q

[14]

O'Reilly MA, Gazdar AF, Morris RE, Whitsett JA: Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line. Biochim Biophys Acta 1988, 970:194–204. 10.1016/0167-4889(88)90179-6

[15]

Metzler MD, Snyder JM: Retinoic acid differentially regulates expression of surfactant-associated proteins in human fetal lung. Endocrinology 1993, 133:1990–1998. 10.1210/endo.133.5.8404646

[16]

George TN, Snyder JM: Regulation of surfactant protein gene expression by retinoic acid metabolites. Pediatr Res 1997, 41:692–701. 10.1203/00006450-199705000-00015

[17]

Sharma RV, Tan E, Fang S, Gurjar MV, Bhalla RC: NOS gene transfer inhibits expression of cell cycle regulatory molecules in vascular smooth muscle cells. Am J Physiol 1999, 276:H1450-H1459.

[18]

Zar J: Biostatistical Analysis. New York: Prentice-Hall, 1984.

[19]

Kimura K, Hattori S, Kabuyama Y, Shizawa Y, Takayanagi J, Nakamura S, Toki S, Matsuda Y, Onodera K, Fukui Y: Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 1994, 269:18961–18967. 10.1016/s0021-9258(17)32260-3

[20]

Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber SL: Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 1995, 377:441–446. 10.1038/377441a0

[21]

Awasthi V, King RJ: PKC, p42/p44 MAPK, and p38 MAPK are required for HGF-induced proliferation of H441 cells. Am J Physiol Lung Cell Mol Physiol 2000, 279:L942-L949. 10.1152/ajplung.2000.279.5.l942

[22]

Pearson RB, Dennis PB, Han JW, Williamson NA, Kozma SC, Wettenhall RE, Thomas G: The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. EMBO J 1995, 14:5279–5287. 10.1002/j.1460-2075.1995.tb00212.x

[23]

Chess PR, Ryan RM, Finkelstein JN: H441 pulmonary epithelial cell mitogenic effects and signaling pathways in response to HGF and TGF-alpha. Exp Lung Res 1998, 24:27–39. 10.3109/01902149809046052

[24]

Whitsett JA, Weaver TE, Lieberman MA, Clark JC, Daugherty C: Differential effects of epidermal growth factor and transforming growth factor-beta on synthesis of Mr = 35,000 surfactant-associated protein in fetal lung. J Biol Chem 1987, 262:7908–7913. 10.1016/s0021-9258(18)47654-5

[25]

Xu X, McCormick-Shannon K, Voelker DR, Mason RJ: KGF increases SP-A and SP-D mRNA levels and secretion in cultured rat alveolar type II cells. Am J Respir Cell Mol Biol 1998, 18:168–178. 10.1165/ajrcmb.18.2.2824

[26]

Roques M, Vidal H: A phosphatidylinositol 3-Kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells. J Biol Chem 1999, 274:34005–34010. 10.1074/jbc.274.48.34005

[27]

Osawa H, Sutherland C, Robey RB, Printz RL, Granner DK: Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin. J Biol Chem 1996, 271:16690–16694. 10.1074/jbc.271.29.17296

[28]

Wagle A, Jivraj S, Garlock GL, Stapleton SR: Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase. J Biol Chem 1998, 273:14968–14974. 10.1074/jbc.273.24.14968

[29]

Agati JM, Yeagley D, Quinn PG: Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem 1998, 273:18751–18759. 10.1074/jbc.273.30.18751

[30]

Kim SJ, Kahn CR: Insulin stimulates p70 S6 kinase in the nucleus of cells. Biochem Biophys Res Commun 1997, 234:681–685. 10.1006/bbrc.1997.6699

[31]

de Groot RP, Ballou LM, Sassone-Corsi P: Positive regulation of the nuclear activator CREM by the mitogen-induced p70 S6 kinase. Immunobiology 1995, 193:155–160. 10.1016/s0171-2985(11)80539-5

Metrics

42

Citations

31

References

Details

Published: Oct 23, 2002
Vol/Issue: 3(1)
License: View

Authors

Cite This Article

Olga L Miakotina, Kelli L Goss, Jeanne M Snyder (2002). Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells. Respiratory Research, 3(1). https://doi.org/10.1186/rr191

Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells

You May Also Like