A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer

W. A. A. Borstlap; P. J. Tanis; T. W. A. Koedam; C. A. M. Marijnen; C. Cunningham; E. Dekker; M. E. van Leerdam; G. Meijer; N. van Grieken; I. D. Nagtegaal; C. J. A. Punt; M. G. W. Dijkgraaf; J. H. De Wilt; G. Beets; E. J. de Graaf; A. A. W van Geloven; M. F. Gerhards; H. L. van Westreenen; A. W. H. van de Ven; P. van Duijvendijk; I. H. J. T. de Hingh; J. W. A. Leijtens; C. Sietses; E. J. Spillenaar-Bilgen; R. J. C. L. M. Vuylsteke; C. Hoff; J. W. A. Burger; W. M. U. van Grevenstein; A. Pronk; R. J. I. Bosker; H. Prins; A. B. Smits; S. Bruin; D. D. Zimmerman; L. P. S. Stassen; M. S. Dunker; M. Westerterp; P. P. Coene; J. Stoot; W. A. Bemelman; J. B. Tuynman

doi:10.1186/s12885-016-2557-x

journal article Jul 21, 2016

A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer

W. A. A. Borstlap P. J. Tanis T. W. A. Koedam C. A. M. Marijnen C. Cunningham E. Dekker M. E. van Leerdam G. Meijer N. van Grieken I. D. Nagtegaal C. J. A. Punt M. G. W. Dijkgraaf J. H. De Wilt G. Beets E. J. de Graaf A. A. W van Geloven M. F. Gerhards H. L. van Westreenen A. W. H. van de Ven P. van Duijvendijk I. H. J. T. de Hingh J. W. A. Leijtens C. Sietses E. J. Spillenaar-Bilgen R. J. C. L. M. Vuylsteke C. Hoff J. W. A. Burger W. M. U. van Grevenstein A. Pronk R. J. I. Bosker H. Prins A. B. Smits S. Bruin D. D. Zimmerman L. P. S. Stassen M. S. Dunker M. Westerterp P. P. Coene J. Stoot W. A. Bemelman J. B. Tuynman

BMC Cancer Vol. 16 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1186/s12885-016-2557-x

Topics

No keywords indexed for this article. Browse by subject →

References

34

[1]

Gross CP, Andersen MS, Krumholz HM, McAvay GJ, Proctor D, Tinetti ME. Relation between Medicare screening reimbursement and stage at diagnosis for older patients with colon cancer. JAMA. 2006;296(23):2815–22. 10.1001/jama.296.23.2815

[2]

Late Side Effects of Short-Course Preoperative Radiotherapy Combined With Total Mesorectal Excision for Rectal Cancer: Increased Bowel Dysfunction in Irradiated Patients—A Dutch Colorectal Cancer Group Study

K.C.M.J. Peeters, C.J.H. van de Velde, J.W.H. Leer et al.

Journal of Clinical Oncology 2005 10.1200/jco.2005.14.779

[3]

Rutten HJ, den Dulk M, Lemmens VE, van de Velde CJ, Marijnen CA. Controversies of total mesorectal excision for rectal cancer in elderly patients. Lancet Oncol. 2008;9(5):494–501. 10.1016/s1470-2045(08)70129-3

[4]

Swellengrebel HA, Marijnen CA, Verwaal VJ, Vincent A, Heuff G, Gerhards MF, et al. Toxicity and complications of preoperative chemoradiotherapy for locally advanced rectal cancer. Br J Surg. 2011;98(3):418–26. 10.1002/bjs.7315

[5]

Lange MM, Maas CP, Marijnen CA, Wiggers T, Rutten HJ, Kranenbarg EK, et al. Urinary dysfunction after rectal cancer treatment is mainly caused by surgery. Br J Surg. 2008;95(8):1020–8. 10.1002/bjs.6126

[6]

Lange MM, van de Velde CJ. Faecal and urinary incontinence after multimodality treatment of rectal cancer. PLoS Med. 2008;5(10):e202. 10.1371/journal.pmed.0050202

[7]

Wallner C, Lange MM, Bonsing BA, Maas CP, Wallace CN, Dabhoiwala NF, et al. Causes of fecal and urinary incontinence after total mesorectal excision for rectal cancer based on cadaveric surgery: a study from the Cooperative Clinical Investigators of the Dutch total mesorectal excision trial. J Clin Oncol. 2008;26(27):4466–72. 10.1200/jco.2008.17.3062

[8]

den Dulk M, Smit M, Peeters K, Kranenbarg EK, Rutten H, et al. A multivariate analysis of limiting factors for stoma reversal in patients with rectal cancer entered into the total mesorectal excision (TME) trial: a retrospective study. Lancet Oncol. 2007;8(4):297–303. 10.1016/s1470-2045(07)70047-5

[9]

Marr R, Birbeck K, Garvican J, Macklin C, Tiffin N, Parsons W, et al. The modern abdominoperineal excision: The next challenge after total mesorectal excision. Ann Surg. 2005;242(1):74–82. 10.1097/01.sla.0000167926.60908.15

[10]

Hompes R, Cunningham C. Extending the role of Transanal Endoscopic Microsurgery (TEM) in rectal cancer. Colorectal Dis. 2011;13 Suppl 7:32–6. 10.1111/j.1463-1318.2011.02778.x

[11]

Bach SP, Hill J, Monson JR, Simson JN, Lane L, Merrie A, et al. A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer. Br J Surg. 2009;96(3):280–90. 10.1002/bjs.6456

[12]

Bosch SL, Teerenstra S, de Wilt JH, Cunningham C, Nagtegaal ID. Predicting lymph node metastasis in pT1 colorectal cancer: a systematic review of risk factors providing rationale for therapy decisions. Endoscopy. 2013;45(10):827–34. 10.1055/s-0033-1344238

[13]

Coco C, Rizzo G, Mattana C, Gambacorta MA, Verbo A, Barbaro B, et al. Transanal endoscopic microsurgery after neoadjuvant radiochemotherapy for locally advanced extraperitoneal rectal cancer: short-term morbidity and functional outcome. Surg Endosc. 2013;27(8):2860–7. 10.1007/s00464-013-2842-6

[14]

Doornebosch PG, Ferenschild FT, de Wilt JH, Dawson I, Tetteroo GW, de Graaf EJ. Treatment of recurrence after transanal endoscopic microsurgery (TEM) for T1 rectal cancer. Dis Colon Rectum. 2010;53(9):1234–9. 10.1007/dcr.0b013e3181e73f33

[15]

Sun G, Tang Y, Li X, Meng J, Liang G. Analysis of 116 cases of rectal cancer treated by transanal local excision. World J Surg Oncol. 2014;12(1):202. 10.1186/1477-7819-12-202

[16]

Morino M, Allaix ME, Caldart M, Scozzari G, Arezzo A. Risk factors for recurrence after transanal endoscopic microsurgery for rectal malignant neoplasm. Surg Endosc. 2011;25(11):3683–90. 10.1007/s00464-011-1777-z

[17]

Min BS, Kim NK, Ko YT, Lee KY, Baek SH, Cho CH, et al. Long-term oncologic results of patients with distal rectal cancer treated by local excision with or without adjuvant treatment. Int J Color Dis. 2007;22(11):1325–30. 10.1007/s00384-007-0339-2

[18]

Ramirez JM, Aguilella V, Valencia J, Ortego J, Gracia JA, Escudero P, et al. Transanal endoscopic microsurgery for rectal cancer. Long-term oncologic results. Int J Color Dis. 2011;26(4):437–43. 10.1007/s00384-011-1132-9

[19]

Coco C, Magistrelli P, Netri G, Cogliandolo S, Carbone L, Morganti AG, et al. Combined modality therapy in low risk (T2N0) rectal cancer. Rays. 1995;20(2):156–64.

[20]

Duek S, Issa N, Hershko D, Krausz M. Outcome of transanal endoscopic microsurgery and adjuvant radiotherapy in patients with T2 rectal cancer: Commentary. Dis Colon Rectum. 2008;51(4):384. 10.1007/s10350-007-9164-5

[21]

Local Recurrence After Complete Clinical Response and Watch and Wait in Rectal Cancer After Neoadjuvant Chemoradiation: Impact of Salvage Therapy on Local Disease Control

Angelita Habr-Gama, Joaquim Gama-Rodrigues, Guilherme P. São Julião et al.

International Journal of Radiation Oncology*Biolog... 2014 10.1016/j.ijrobp.2013.12.012

[22]

Slankamenac K, Graf R, Barkun J, Puhan MA, Clavien PA. The comprehensive complication index: a novel continuous scale to measure surgical morbidity. Ann Surg. 2013;258(1):1–7. 10.1097/sla.0b013e318296c732

[23]

Wiens BL, Zhao W. The role of intention to treat in analysis of noninferiority studies. Clin Trials. 2007;4(3):286–91. 10.1177/1740774507079443

[24]

Lamers LM, Stalmeier PF, McDonnell J, Krabbe PF, van Busschbach JJ. Measuring the quality of life in economic evaluations: the Dutch EQ-5D tariff. Ned Tijdschr Geneeskd. 2005;149(28):1574–8.

[25]

Verseveld M, de Graaf EJ, Verhoef C, van Meerten E, Punt CJ, de Hingh IH, et al. Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery (CARTS study). Br J Surg. 2015;102(7):853–60. 10.1002/bjs.9809

[26]

Greenberg JA, Shibata D, Herndon 2nd JE, Steele Jr GD, Mayer R, Bleday R. Local excision of distal rectal cancer: an update of cancer and leukemia group B 8984. Dis Colon Rectum. 2008;51(8):1185–91. discussion 91-4. 10.1007/s10350-008-9231-6

[27]

Duek S, Issa N, Hershko D, Krausz M. Outcome of transanal endoscopic microsurgery and adjuvant radiotherapy in patients with T2 rectal cancer. Dis Colon Rectum. 2008;51(4):379–83. 10.1007/s10350-007-9164-5

[28]

Gopaul D, Belliveau P, Vuong T, Trudel J, Vasilevsky CA, Corns R, et al. Outcome of local excision of rectal carcinoma. Dis Colon Rectum. 2004;47(11):1780–8. 10.1007/s10350-004-0678-9

[29]

Stipa F, Burza A, Lucandri G, Ferri M, Pigazzi A, Ziparo V, et al. Outcomes for early rectal cancer managed with transanal endoscopic microsurgery: A 5-year follow-up study. Surg Endosc Other Interv Tech. 2006;20(4):541–5. 10.1007/s00464-005-0408-y

[30]

Mendenhall WM, Morris CG, Rout WR, Zlotecki RA, Lind DS, Hochwald SN, et al. Local excision and postoperative radiation therapy for rectal adenocarcinoma. Int J Cancer J Int du cancer. 2001;96(Suppl):89–96. 10.1002/ijc.10354

[31]

Lamont JP, McCarty TM, Digan RD, Jacobson R, Tulanon P, Lichliter WE. Should locally excised T1 rectal cancer receive adjuvant chemoradiation? Am J Surg. 2000;180(6):402–5. discussion 5-6. 10.1016/s0002-9610(00)00493-1

[32]

Wagman R, Minsky BD, Cohen AM, Saltz L, Paty PB, Guillem JG. Conservative management of rectal cancer with local excision and postoperative adjuvant therapy. Int J Radiat Oncol Biol Phys. 1999;44(4):841–6. 10.1016/s0360-3016(99)00094-2

[33]

Steele Jr GD, Herndon JE, Bleday R, Russell A, Benson 3rd A, Hussain M, et al. Sphincter-sparing treatment for distal rectal adenocarcinoma. Ann Surg Oncol. 1999;6(5):433–41. 10.1007/s10434-999-0433-5

[34]

Taylor RH, Hay JH, Larsson SN. Transanal local excision of selected low rectal cancers. Am J Surg. 1998;175(5):360–3. 10.1016/s0002-9610(98)00038-5

Cited By

93

Organ preservation in rectal cancer: an endoscopist’s perspective on current evidence and future directions

Takashi Kanesaka, Kenichiro Imai · 2026

Japanese Journal of Clinical Oncolo...

Metrics

93

Citations

34

References

Details

Published: Jul 21, 2016
Vol/Issue: 16(1)
License: View

Authors

Department of Clinical Epidemiology and Biostatistics

Department of Surgery, Gelre Hospital, Apeldoorn, The Netherlands

E. J. Spillenaar-Bilgen

R

R. J. C. L. M. Vuylsteke

W. M. U. van Grevenstein

Department of Surgery Academic Medical Center Amsterdam The Netherlands

J

J. B. Tuynman

Cite This Article

W. A. A. Borstlap, P. J. Tanis, T. W. A. Koedam, et al. (2016). A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer. BMC Cancer, 16(1). https://doi.org/10.1186/s12885-016-2557-x

A multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer

You May Also Like