Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries

Moses Ocan; Ekwaro A. Obuku; Freddie Bwanga; Dickens Akena; Sennono Richard; Jasper Ogwal-Okeng; Celestino Obua

doi:10.1186/s12889-015-2109-3

journal article Open Access Aug 01, 2015

Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries

Moses Ocan

Ekwaro A. Obuku Freddie Bwanga Dickens Akena Sennono Richard Jasper Ogwal-Okeng Celestino Obua

BMC Public Health Vol. 15 No. 1 · Springer Science and Business Media LLC

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References

63

[1]

World Health Organization. Guidelines for the regulatory assessment of Medicinal Products for use in self-medication. In., vol. WHO/EDM/QSM/00.1. Geneva, Switzerland: WHO; 2000. http://apps.who.int/medicinedocs/en/d/Jh1462e/6.html#Jh1462e.6.1 . Accessed on 22 June 2015

[2]

Cars O, Nordberg P. Antibiotic resistance –The faceless threat. Int J Risk Saf Med. 2005;17:103–10. 10.3233/jrs-2005-347

[3]

Morgan DJ, Okeke IN, Laxminarayan R, Perencevich EN, Weisenberg S. Non-prescription antimicrobial use worldwide: A systematic review. Lancet Infect Dis. 2011;11:692–701. 10.1016/s1473-3099(11)70054-8

[4]

Esimone CO, Nworu CS, Obina PU. Utilization of Antimicrobial agents with and without prescriptions by Out-patients in selected pharmacies in south-eastern Nigeria. Pharm World Sci. 2007;29:655–60. 10.1007/s11096-007-9124-0

[5]

Yousef AM, Al-Bakri AG, Bustajani Y, Wazaify M. Self-medication patterns in Amman, Jordan. Pharm World Sci. 2008;30(1):24–30. 10.1007/s11096-007-9135-x

[6]

Okeke IN, Klugman KP, Bhutta ZA. Antimicrobial resistance in developing countries Part II: strategies for containment. Lancet Infect Dis. 2005;5:568–80. 10.1016/s1473-3099(05)70217-6

[7]

World Health Organization. Community-Based Surveillance of Antimicrobial use and Resistance in Resource constrained settings. A report on five pilot projects. Geneva, Switzerland: WHO; 2009. www.apps.who.int/medicinedocs/documents/s16168e.pdf . Accessed on 22/June 2015.

[8]

Mehta U, Durrheim DN, Blumberg L, Donohue S, Hansford F, Mabuza A, et al. Malaria deaths as sentinel events to monitor healthcare delivery and antimalarial drug safety. Trop Med Int Healthsss. 2007;12(5):617–28. 10.1111/j.1365-3156.2007.01823.x

[9]

Skliros E, Panagiotis M, Athanasia P, Aristofanis G, Matzouranis G. Self-medication with antibiotics in rural population in Greece: A cross-sectional multicenter study. BMC Fam Pract. 2010;8:1–58.

[10]

Hughes CM, McElnay JC, Fleming GF. Benefits and Risks of Self-medication. Drug Safety. 2001;24(14):1027–37. 10.2165/00002018-200124140-00002

[11]

Radyowijati A, Haak H. Improving antibiotic use in low-income countries: an overview of evidence on determinants. Soc Sci Med. 2003;57:733–44. 10.1016/s0277-9536(02)00422-7

[12]

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Loannidis JPA, et al. The PRISMA Statement for Reporting Systematic Reviews and Meta-analysis of Studies the Evaluate Healthcare Interentions: Explanation and Elaboration. PLoS Med. 2009;6(7), e1000100. 10.1371/journal.pmed.1000100

[13]

Vandenbroucke JP, Von Elm E, Altman DG, Gotzsche PC, Mulrow CD, Pocock SJ, Poole C, Schlesselman JJ, Egger M. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and elaboration. Int J Surg. 2014, xxx:1-25 (Article in Press). 10.1016/j.ijsu.2014.07.014

[14]

Ansah EK, Powell-Jackson T. Can we trust measures of healthcare utilization from household surveys? BMC Public Health. 2013;13:853. 10.1186/1471-2458-13-853

[15]

Enato EF, Sounyo AA, Einarson TR. Medication utilization and illness management study in Nigeria. Ann Pharmacother. 2011;45:924–30. 10.1345/aph.1q051

[16]

Widayati A, Suryawati S, Charlottee C, Hiller J. Self-medication with antibiotics in Yogyakarta City Indonesia: A cross-sectional population-based survey. BMC Research Notes. 2011;4:491. 10.1186/1756-0500-4-491

[17]

Sihavong A, Lundborg CS, Syhakhang LAK, Tomson G, Wahlstrom R. Antimicrobial self-medication for reproductive tract infection in two provinces in Lao Peoples’ Democratic Republic. Sex Transm Infect. 2009;82:182–6. 10.1136/sti.2005.016352

[18]

Barah F, Gonclaves V. Antibiotic use and knowledge in the community in Kalamoon, Syrian Arab Republic: a cross-sectional study. EMHJ. 2010;16(5):516–21.

[19]

Awad A, Eltayeb I, Matowe L, Thalib L. Self-medication with antibiotics and antimalarials in the community of Khartoum state, Sudan. J Pharm Pharmaceut Sci. 2005;8(2):326–31.

[20]

Auta A, Banwat SB, Dayom DW, Shalkur D, Aru MO. Occurance and treatment of common health problems in a Nigerian community. J Young Pharm. 2012;4(1):49–53. 10.4103/0975-1483.93571

[21]

Al-Azzam SI, Al-Husein BA, Alzoubi F, Masadeh MM, Al-horani S. Self-medicaiton with antibiotics in Jordanian Population. IJOMEH. 2007;20(4):373–80.

[22]

Shehadeh M, Suaifan G, Darwish RM, Wazaify M, Zaru L, Alja’fari S. Knowledge, attitudes and behavior regarding antibiotics use and misuse among adults in the community of Jordan. A pilot study. Saudi Pharm J. 2012;20:125–33. 10.1016/j.jsps.2011.11.005

[23]

Sanjana P, Barans MJ, Bangs MJ, Ompusunggu S, Elyazar I, Marwoto H, et al. Survey of community knowledge, attitudes and practices during a malaria epidemic in central Java, Indonesia. Am J Trop Med Hyg. 2006;75(5):783–9. 10.4269/ajtmh.2006.75.783

[24]

Askarian M, Maharlouie N. Irrational Antibiotic use among secondary school teachers and university faculty members in Shiraz, Iran. Int J Prev Med. 2012;3(12):839–45. 10.4103/2008-7802.104854

[25]

Mossa DA, Wabe NT, Angamo MT. Self-medication with antibiotics and antimalarials in the community of Silte zone, South Ethiopia. TAF Preventive medicine Bulletin. 2012;11(5):529–36. 10.5455/pmb.1-1314892446

[26]

Sapkota AR, Coker ME, Goldstein RE, Atkinson NL, Sweet SJ, Sopeju PO. Self medication with antibiotics for the treatment of menstrual symptoms in south west Nigeria: a cross-sectional study. BMC Public Health. 2010;10:610. 10.1186/1471-2458-10-610

[27]

Sarahroodi S, Arzi A. Self-medication with Antibiotics, Is it a problem among Iranian College Students in Tehran? J Biol Sci. 2009;9(8):829–32. 10.3923/jbs.2009.829.832

[28]

Omole MK, Onademuren OT. A survey of antimalarial drug use practices among urban dwellers in Abeokuta, Nigeria. Afr J Biomed Res. 2010;13:1–7.

[29]

Hussain S, Malik F, Hameed A, Riaz H. Exploring Health seeking behavior, Medicine use and self-medication in rural and urban Parkistan. Southern Med Rev. 2010;3:32–4.

[30]

Sawalha AF. Self-medication with antibiotics: A study in Palestine. Int J Risk Safety Med. 2008;20:213–22. 10.3233/jrs-2008-0445

[31]

Shankar PR, Partha P, Shenoy N. Self-medication and non-doctor prescription practices in Pokhara valley, Western Nepal: a questionnaire-based study. BMC Fam Pract. 2002;3:1–7. 10.1186/1471-2296-3-17

[32]

Deressa W, Ali A, Enqusellassie F. Self-treatment of malaria in rural communities, Butajira Southern Ethiopia. Bull World Health Organ. 2003;81:261–8.

[33]

Chowdhury N, Matin F, Chowdhury SKFUA. Medication taking behavior of students attending a private university in Bangladesh. Int J Adolesc Med Health. 2009;21(3):361–70. 10.1515/ijamh.2009.21.3.361

[34]

Abdo-Rabbo A. Household survey of treatment of malaria in Hajjah, Yemen. East Mediterr Health J. 2003;9(14):600–6. 10.26719/2003.9.4.600

[35]

Self medication for oral health problems in Cameroon

Michael A. Agbor, Clement C. Azodo

International Dental Journal 2011 10.1111/j.1875-595x.2011.00058.x

[36]

Bano N, Najan R, Qazi F. Irrational drug use based on self-medication for some common clinical conditions in an educated population of Karachi. Pak J Med Sci. 2012;28(3):359–62.

[37]

de Oliveira CM, Buzzatto W, Garcia R, Baracho CNV, Arango HG: Survey of the occurrence of self-medication in the Municipality of Itajuba-MG. 2004.

[38]

Jassim A. In-home drug storage and self-medication with antimicrobial drugs in Basrah, Iraq. Oman Med J. 2010;25(2):1–9. 10.5001/omj.2010.25

[39]

Jombo GTA, Araoye MA, Damen JG. Malaria self-medication and choices of drugs for its treatment among residents of a malaria endemic community in Western Africa. Asian Pac J Trop Dis. 2011;10:16.

[40]

Lima GB, Nunes LCC, de Barros JA C. The use of medicines storage in the household in a population assisted by Family Health Program. Sci Public Health. 2010;15 Suppl 3:3517–22.

[41]

Nounou B, Cattaneo ME, Salmon R, Palasezze L, Boccaleri J, Cestona E, et al. A study regarding consumption and self-medication with antibiotics in the city of Laplata (Buenos Aires, Argentina). Lat Am J Pharm. 2009;28(4):544–51.

[42]

Ngasha DS, Njunda AL, Kamga HLF, Ngasha SM, Assob JCN, WIysonge CS, et al. Knowledge and practices relating to malaria in a semi-urban area of Camerron: Choices and sources of antimalarials, self-medication and resistance. Pan Afr Med J. 2011;9:8.

[43]

Okumura J, Wakai S, Umenai T. Drug utilization and self-medication in rural communities in Vietnam. Soc Sci Med. 2002;54:1875–86. 10.1016/s0277-9536(01)00155-1

[44]

Onanuga A, Temedie TC. Multidrug-resistant intestinal Staphylococcus aureus among self-medicated Healthy Adults in Amassoma, South-South Nigeria. J Health Popul Nutr. 2011;29(5):446–53. 10.3329/jhpn.v29i5.8898

[45]

Onohwosafe PS, Olaseha IO. Factors influencing self-medication among students of Abadina College, Ibadan, Nigeria. Int J Health Promot Educ. 2013;42(1):27–32. 10.1080/14635240.2004.10708007

[46]

Osemene KP, Lamikanra A. A study of the prevalence of self-medication practice among university students in Southwestern Nigeria. Trop J Pharmaceut Res. 2012;11(4):683–9.

[47]

Oyetunde OO, Olugbake OA, Famudehin KF. Evaluation of use of antibiotics without prescription among young adults. Afr J Pharm Pharmacol. 2010;4(10):760–2.

[48]

Yousif MA. In-home storage and utilization habits: a Sudanese study. East Mediterr Health J. 2002;8(2/3):422–31. 10.26719/2002.8.2-3.422

[49]

Sharif SI, Abduelkarem AR, Bustami HA, Haddad LI, Khalil DS. Trends of home drug storage and use in different regions across the northern United Arab Emirates. Med Princ Pract. 2009;19:355–8. 10.1159/000316372

[50]

Bennadi D. Self-medication: A current challenge. J Basic Clin Pharma. 2014;5:19–23. 10.4103/0976-0105.128253

Showing 50 of 63 references

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Published: Aug 01, 2015
Vol/Issue: 15(1)
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Cite This Article

Moses Ocan, Ekwaro A. Obuku, Freddie Bwanga, et al. (2015). Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries. BMC Public Health, 15(1). https://doi.org/10.1186/s12889-015-2109-3

Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries

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