Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications

Jie Chen; Tianyu Zhu; Jinxin Li; Ho Yin Ng; Yixiong Zhou; Xiang Gu; Shiqiong Xu; Renbing Jia

doi:10.1186/s12943-025-02533-1

journal article Open Access Dec 18, 2025

Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications

Jie Chen

Tianyu Zhu

Jinxin Li Ho Yin Ng Yixiong Zhou Xiang Gu

Shiqiong Xu Renbing Jia

Molecular Cancer Vol. 25 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1186/s12943-025-02533-1

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Published: Dec 18, 2025
Vol/Issue: 25(1)
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Authors

J

Jie Chen

Guangdong Academy of Medical Sciences

Department of Ophthalmology Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200011 China

Funding

National Natural Science Foundation of China Award: 82403163

Science and Technology Commission of Shanghai Municipality Award: 25Y22800200

Science and Technology Commission of Shanghai Award: No.22Y31900700

Cross-Disciplinary Research Fund Project of Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine Award: JYJC202303

Program of Innovative Research Team of High-Level Local Universities in Shanghai Award: No.SHSMU-ZDCX20210902

National Clinical Key Specialties Program

Cite This Article

Jie Chen, Tianyu Zhu, Jinxin Li, et al. (2025). Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications. Molecular Cancer, 25(1). https://doi.org/10.1186/s12943-025-02533-1

Cancer-associated fibroblasts in the tumor microenvironment: heterogeneity, crosstalk mechanisms, and therapeutic implications

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