Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

Huldani Huldani; Ahmed Ibraheem Rashid; Khikmatulla Negmatovich Turaev; Maria Jade Catalan Opulencia; Walid Kamal Abdelbasset; Dmitry Olegovich Bokov; Yasser Fakri Mustafa; Moaed E. Al-Gazally; Ali Thaeer Hammid; Mustafa M. Kadhim; Seyed Hossein Ahmadi

doi:10.1186/s12964-022-00972-7

journal article Open Access Oct 26, 2022

Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

Huldani Huldani Ahmed Ibraheem Rashid Khikmatulla Negmatovich Turaev Maria Jade Catalan Opulencia Walid Kamal Abdelbasset

Dmitry Olegovich Bokov Yasser Fakri Mustafa

Moaed E. Al-Gazally Ali Thaeer Hammid Mustafa M. Kadhim Seyed Hossein Ahmadi

Cell Communication and Signaling Vol. 20 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1186/s12964-022-00972-7

Abstract

AbstractConcanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular mechanism. It has been revealed that ConA can bind to several receptors on cancerous and normal cells and modulate the related signaling cascades. The most studied host receptor for ConA is MT1-MMP, responsible for most of the lectin's modulations, ranging from activating immune cells to killing tumor cells. In this study, in addition to studying the effect of ConA on signaling and immune cell function, we will focus on the most up-to-date advancements that unraveled the molecular mechanisms by which ConA can induce autophagy and apoptosis in various cancer cell types, where it has been found that P73 and JAK/STAT3 are the leading players. Moreover, we further discuss the main signaling molecules causing liver injury as the most significant side effect of the lectin injection. Altogether, these findings may shed light on the complex signaling pathways controlling the diverse responses created via ConA treatment, thereby modulating these complex networks to create more potent lectin-based cancer therapy.

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Details

Published: Oct 26, 2022
Vol/Issue: 20(1)
License: View

Authors

H

Huldani Huldani

A

Ahmed Ibraheem Rashid

K

Khikmatulla Negmatovich Turaev

M

Maria Jade Catalan Opulencia

W

Walid Kamal Abdelbasset

D

Dmitry Olegovich Bokov

Y

Yasser Fakri Mustafa

Department of Pharmaceutical Chemistry, College of Pharmacy University of Mosul Mosul Iraq

Cite This Article

Huldani Huldani, Ahmed Ibraheem Rashid, Khikmatulla Negmatovich Turaev, et al. (2022). Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential. Cell Communication and Signaling, 20(1). https://doi.org/10.1186/s12964-022-00972-7

Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential

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