The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review

Donghui Bian; Yan Wu; Guodong Song; Ramyar Azizi; Amir Zamani

doi:10.1186/s13287-021-02697-9

journal article Open Access Jan 24, 2022

The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review

Donghui Bian Yan Wu

Guodong Song

Ramyar Azizi Amir Zamani

Stem Cell Research & Therapy Vol. 13 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1186/s13287-021-02697-9

Abstract

AbstractRecently, mesenchymal stromal cells (MSCs) and also their exosome has become a game-changing tool in the context of tissue engineering and regenerative medicine. MSCs due to their competencies to establish skin cells, such as fibroblast and keratinocyte, and also their unique attribute to suppress inflammation in wound site has attracted increasing attention among scholars. In addition, MSC’s other capabilities to induce angiogenesis as a result of secretion of pro-angiogenic factors accompanied with marked anti-fibrotic activities, which mainly mediated by the releases matrix metalloproteinase (MMPs), make them a rational and effective strategy to accelerate wound healing with a small scar. Since the chief healing properties of the MSCs depend on their paracrine effects, it appears that MSCs-derived exosomes also can be an alternative option to support wound healing and skin regeneration as an innovative cell-free approach. Such exosomes convey functional cargos (e.g., growth factor, cytokine, miRNA, etc.) from MSCs to target cells, thereby affecting the recipient skin cells’ biological events, such as migration, proliferation, and also secretion of ECM components (e.g., collagen). The main superiorities of exosome therapy over parental MSCs are the diminished risk of tumor formation and also lower immunogenicity. Herein, we deliver an overview of recent in vivo reports rendering the therapeutic benefits of the MSCs-based therapies to ease skin wound healing, and so improving quality of life among patients suffering from such conditions.

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Details

Published: Jan 24, 2022
Vol/Issue: 13(1)
License: View

Authors

Department of Pathogen Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.

Cite This Article

Donghui Bian, Yan Wu, Guodong Song, et al. (2022). The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review. Stem Cell Research & Therapy, 13(1). https://doi.org/10.1186/s13287-021-02697-9

The application of mesenchymal stromal cells (MSCs) and their derivative exosome in skin wound healing: a comprehensive review

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