Microfluidic biosensors for biomarker detection in body fluids: a key approach for early cancer diagnosis

Yingyu Zhou; Jia Lu; Ting Gong; Elena Ibáñez; Alejandro Cifuentes; Weihong Lu

doi:10.1186/s40364-024-00697-4

journal article Open Access Dec 05, 2024

Microfluidic biosensors for biomarker detection in body fluids: a key approach for early cancer diagnosis

Yingyu Zhou

Biomarker Research Vol. 12 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1186/s40364-024-00697-4

Abstract

AbstractEarly detection of cancer significantly improves patient outcomes, with biomarkers offering a promising avenue for earlier and more precise diagnoses. Microfluidic biosensors have emerged as a powerful tool for detecting these biomarkers in body fluids, providing enhanced sensitivity, specificity, and rapid analysis. This review focuses on recent advances in microfluidic biosensors from 2018 to 2024, detailing their operational principles, fabrication techniques, and integration with nanotechnology for cancer biomarker detection. Additionally, we have reviewed recent innovations in several aspects of microfluidic biosensors, such as novel detection technologies, nanomaterials and novel microfluidic chip structures, which significantly enhance detection capabilities. We highlight key biomarkers pertinent to early cancer detection and explore how these innovations in biosensor technology contribute to the evolving landscape of personalized medicine. We further explore how these technologies could be incorporated into clinical cancer diagnostic workflows to improve early detection and treatment outcomes. These innovations could help enable more precise and personalized cancer diagnostics. In addition, this review addresses several important issues such as enhancing the scalability and sensitivity of these biosensors in clinical settings and points out future possibilities of combining artificial intelligence diagnostics with microfluidic biosensors to optimize their practical applications. This overview aims to guide future research and clinical applications by addressing current challenges and identifying opportunities for further development in the field of biomarker research.

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Details

Published: Dec 05, 2024
Vol/Issue: 12(1)
License: View

Authors

Department of Bioactivity and Food Analysis Institute of Food Science Research (CIAL‐CSIC) Nicolás Cabrera 9, Campus Cantoblanco 28049 Madrid Spain

Funding

National Natural Science Foundation of China Award: 32402105

Heilongjiang Touyan Team Award: HITTY-20190034

Aerospace Science and Technology Collaborative Innovation Program Award: AUEA5740600823

Cite This Article

Yingyu Zhou, Jia Lu, Ting Gong, et al. (2024). Microfluidic biosensors for biomarker detection in body fluids: a key approach for early cancer diagnosis. Biomarker Research, 12(1). https://doi.org/10.1186/s40364-024-00697-4

Microfluidic biosensors for biomarker detection in body fluids: a key approach for early cancer diagnosis

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