A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

Franziska C. Sandmeier; C. Richard Tracy; Sally Dupré; Kenneth Hunter

doi:10.1242/bio.20122527

journal article Open Access Aug 28, 2012

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

Franziska C. Sandmeier C. Richard Tracy Sally Dupré Kenneth Hunter

Biology Open Vol. 1 No. 11 pp. 1078-1082 · The Company of Biologists

View at Publisher Save 10.1242/bio.20122527

Abstract

Summary
Vertebrate immune systems are understood to be complex and dynamic, with trade-offs among different physiological components (e.g., innate and adaptive immunity) within individuals and among taxonomic lineages. Desert tortoises (Gopherus agassizii) immunised with ovalbumin (OVA) showed a clear trade-off between levels of natural antibodies (NAbs; innate immune function) and the production of acquired antibodies (adaptive immune function). Once initiated, acquired antibody responses included a long-term elevation in antibodies persisting for more than one year. The occurrence of either (a) high levels of NAbs or (b) long-term elevations of acquired antibodies in individual tortoises suggests that long-term humoral resistance to pathogens may be especially important in this species, as well as in other vertebrates with slow metabolic rates, concomitantly slow primary adaptive immune responses, and long life-spans.

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Details

Published: Aug 28, 2012
Vol/Issue: 1(11)
Pages: 1078-1082
License: View

Authors

F

Franziska C. Sandmeier

Ecology, Evolution, and Conservation Biology Program, Department of Biology, University of Nevada, Reno, NV 89557, USA

C

C. Richard Tracy

Ecology, Evolution, and Conservation Biology Program, Department of Biology, University of Nevada, Reno, NV 89557, USA

S

Sally Dupré

Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA

K

Kenneth Hunter

Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA

Cite This Article

Franziska C. Sandmeier, C. Richard Tracy, Sally Dupré, et al. (2012). A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease. Biology Open, 1(11), 1078-1082. https://doi.org/10.1242/bio.20122527

A trade-off between natural and acquired antibody production in a reptile: implications for long-term resistance to disease

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