The constriction and scission machineries involved in mitochondrial fission

Felix Kraus; Michael T. Ryan

doi:10.1242/jcs.199562

journal article Sep 15, 2017

The constriction and scission machineries involved in mitochondrial fission

Felix Kraus

Michael T. Ryan

Journal of Cell Science Vol. 130 No. 18 pp. 2953-2960 · The Company of Biologists

View at Publisher Save 10.1242/jcs.199562

Abstract

ABSTRACT
A key event in the evolution of eukaryotic cells was the engulfment of an aerobic bacterium by a larger anaerobic archaebacterium, leading to a close relationship between the host and the newly formed endosymbiont. Mitochondria, originating from this event, have evolved to be the main place of cellular ATP production. Maintaining elements of their independence, mitochondria undergo growth and division in the cell, thereby ensuring that new daughter cells inherit a mitochondrial complement. Mitochondrial division is also important for other processes, including quality control, mitochondrial (mt)DNA inheritance, transport and cell death. However, unlike bacterial fission, which uses a dynamin-related protein to constrict the membrane at its inner face, mitochondria use dynamin and dynamin-related proteins to constrict the outer membrane from the cytosolic face. In this Review, we summarize the role of proteins from the dynamin superfamily in mitochondrial division. This includes recent findings highlighting that dynamin-2 (Dnm2) is involved in mitochondrial scission, which led to the reappraisal of the role of dynamin-related protein 1 (Drp1; also known as Dnm1l) and its outer membrane adaptors as components of the mitochondrial constriction machinery along with ER components and actin.

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Details

Published: Sep 15, 2017
Vol/Issue: 130(18)
Pages: 2953-2960
License: View

Authors

F

Felix Kraus

Monash Biomedicine Discovery Institute, Monash University Department of Biochemistry and Molecular Biology , , 3800 Melbourne , Australia

M

Michael T. Ryan

Monash Biomedicine Discovery Institute, Monash University Department of Biochemistry and Molecular Biology , , 3800 Melbourne , Australia

Funding

National Health and Medical Research Council

Australian Research Council Award: DP160102176

Cite This Article

Felix Kraus, Michael T. Ryan (2017). The constriction and scission machineries involved in mitochondrial fission. Journal of Cell Science, 130(18), 2953-2960. https://doi.org/10.1242/jcs.199562

The constriction and scission machineries involved in mitochondrial fission

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