Single infrared light pulses induce excitatory and inhibitory neuromodulation

Xuedong Zhu; Jen-Wei Lin; Ahmet Turnali; Michelle Y. Sander

doi:10.1364/boe.444577

journal article Dec 16, 2021

Single infrared light pulses induce excitatory and inhibitory neuromodulation

Xuedong Zhu

Jen-Wei Lin Ahmet Turnali

Michelle Y. Sander

Biomedical Optics Express Vol. 13 No. 1 pp. 374 · Optica Publishing Group

View at Publisher Save 10.1364/boe.444577

Abstract

The excitatory and inhibitory effects of single and brief infrared (IR) light pulses (2 µm) with millisecond durations and various power levels are investigated with a custom-built fiber amplification system. Intracellular recordings from motor axons of the crayfish opener neuromuscular junction are performed ex vivo. Single IR light pulses induce a membrane depolarization during the light pulses, which is followed by a hyperpolarization that can last up to 100 ms. The depolarization amplitude is dependent on the optical pulse duration, total energy deposition and membrane potential, but is insensitive to tetrodotoxin. The hyperpolarization reverses its polarity near the potassium equilibrium potential and is barium-sensitive. The membrane depolarization activates an action potential (AP) when the axon is near firing threshold, while the hyperpolarization reversibly inhibits rhythmically firing APs. In summary, we demonstrate for the first time that single and brief IR light pulses can evoke initial depolarization followed by hyperpolarization on individual motor axons. The corresponding mechanisms and functional outcomes of the dual effects are investigated.

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References

63

[1]

Fekete J. Neural Eng. (2020) 10.1088/1741-2552/abb3b2

[2]

Hart Adv. Opt. Mater. (2019) 10.1002/adom.201900385

[3]

ZhaoWong "Stimulation of neurons with infrared radiation" (2016) 10.1007/978-1-4939-1758-7_17

[4]

Richter Hear. Res. (2014) 10.1016/j.heares.2014.03.008

[5]

Chernov Neurophoton (2014) 10.1117/1.nph.1.1.011011

[6]

Richter Laser & Photon. Rev. (2011) 10.1002/lpor.200900044

[7]

Xu Sci. Adv. (2019) 10.1126/sciadv.aau7046

[8]

Zhang Neurophoton. (2020) 10.1117/1.nph.7.1.015014

[9]

Cayce Cell Calcium (2014) 10.1016/j.ceca.2014.01.004

[10]

Cayce NeuroImage (2011) 10.1016/j.neuroimage.2011.03.084

[11]

Cayce NeuroImage (2014) 10.1016/j.neuroimage.2013.08.040

[12]

Rajguru Hear. Res. (2010) 10.1016/j.heares.2010.06.021

[13]

Xu Neurophoton. (2018) 10.1117/1.nph.5.4.045002

[14]

Thompson Hear. Res. (2015) 10.1016/j.heares.2015.03.005

[15]

Ford J. Neural Eng. (2018) 10.1088/1741-2552/aa795f

[16]

Fried IEEE J. Sel. Top. Quantum Electron. (2007) 10.1109/jstqe.2007.910119

[17]

Cayce Neurophotonics (2015) 10.1117/1.nph.2.1.015007

[18]

Wells Biophys. J. (2007) 10.1529/biophysj.107.104786

[19]

Shapiro Nat. Commun. (2012) 10.1038/ncomms1742

[20]

Mou IEEE Trans. Biomed. Eng. (2012) 10.1109/tbme.2012.2194146

[21]

Duke Sci Rep (2013) 10.1038/srep02600

[22]

Zhu Biomed. Opt. Express (2019) 10.1364/boe.10.006580

[23]

Eom Small (2014) 10.1002/smll.201400599

[24]

Carvalho-de-Souza Neuron (2015) 10.1016/j.neuron.2015.02.033

[25]

Carvalho-de-Souza Biophys. J. (2018) 10.1016/j.bpj.2017.11.018

[26]

Feyen Sci Rep (2016) 10.1038/srep22718

[27]

Yoo ACS Nano (2019) 10.1021/acsnano.8b07277

[28]

Heat pulse excitability of vestibular hair cells and afferent neurons

Richard D. Rabbitt, Alan M. Brichta, Hessam Tabatabaee et al.

Journal of Neurophysiology 2016 10.1152/jn.00110.2016

[29]

Liu Biophysical Journal (2014) 10.1016/j.bpj.2014.03.008

[30]

Plaksin Phys. Rev. X (2018) 10.1103/physrevx.8.011043

[31]

Beier J. Neural Eng. (2014) 10.1088/1741-2560/11/6/066006

[32]

Pakhomov Biochem. Biophys. Res. Commun. (2009) 10.1016/j.bbrc.2009.05.035

[33]

Yao Biophys. J. (2009) 10.1016/j.bpj.2009.02.016

[34]

Albert J. Neurophysiol. (2012) 10.1152/jn.00424.2011

[35]

Dittami The Journal of Physiology (2011) 10.1113/jphysiol.2010.198804

[36]

Lumbreras J. Neurophysiol. (2014) 10.1152/jn.00253.2014

[37]

Barrett J. Neurophysiol. (2018) 10.1152/jn.00740.2017

[38]

Moreau J. Biophotonics (2018) 10.1002/jbio.201700020

[39]

Borrachero-Conejo The FASEB Journal (2020) 10.1096/fj.201903049r

[40]

Lothet Sci Rep (2017) 10.1038/s41598-017-03374-9

[41]

Ganguly J. Neural Eng. (2019) 10.1088/1741-2552/ab131b

[42]

Ganguly Neurophotonics (2019) 10.1117/1.nph.6.4.040501

[43]

Zhu Neurophoton. (2020) 10.1117/1.nph.7.4.045003

[44]

Hodgkin The Journal of Physiology (1949) 10.1113/jphysiol.1949.sp004388

[45]

Frankenhaeuser The Journal of Physiology (1963) 10.1113/jphysiol.1963.sp007269

[46]

Walsh Proc. SPIE (2017) 10.1117/12.2249521

[47]

Tolstykh Proc. SPIE (2020) 10.1117/12.2546667

[48]

Horváth Microsyst Nanoeng (2020) 10.1038/s41378-020-0153-3

[49]

Paris Biomed. Opt. Express (2017) 10.1364/boe.8.004568

[50]

Lamas Int. J. Mol. Sci. (2019) 10.3390/ijms20102371

Showing 50 of 63 references

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Details

Published: Dec 16, 2021
Vol/Issue: 13(1)
Pages: 374
License: View

Authors

Boston University

Boston University

Boston University

Boston University

Funding

Air Force Office of Scientific Research Award: FA9550-17-1-0276

Cite This Article

Xuedong Zhu, Jen-Wei Lin, Ahmet Turnali, et al. (2021). Single infrared light pulses induce excitatory and inhibitory neuromodulation. Biomedical Optics Express, 13(1), 374. https://doi.org/10.1364/boe.444577

Single infrared light pulses induce excitatory and inhibitory neuromodulation

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