Fast quantitative phase imaging based on Kramers-Kronig relations in space domain

Cheng Shen; Jiubin Tan; Xiu Wen; Ming Sun; Guancheng Huang; Shutian Liu; Zhengjun Liu

doi:10.1364/oe.444623

journal article Nov 24, 2021

Fast quantitative phase imaging based on Kramers-Kronig relations in space domain

Cheng Shen

Jiubin Tan

Xiu Wen Ming Sun

Guancheng Huang Shutian Liu

Zhengjun Liu

Optics Express Vol. 29 No. 25 pp. 41067 · Optica Publishing Group

View at Publisher Save 10.1364/oe.444623

Abstract

A fast quantitative phase imaging technology based on space-domain Kramers-Kronig relations is proposed. By incorporating Kramers-Kronig relations, we acquire distributions on phase via measurements of intensity over the captured spectrum. Only using four low-resolution images, we built a microscope prototype with a half-pitch resolution of 625 nm (final effective imaging performance of 0.5 NA) and a field of view of 3.8 mm2 at a wavelength of 625 nm via a 10×/0.25 NA objective. Correspondingly, the data recording time is 0.16 s, and the space-bandwidth-time product is 243.3 megapixels per second. It is worth noting that the proposed scheme requires neither mechanical scanning nor extra illumination like interferometry. Meanwhile, the reconstruction is non-iterative and object-independent. Our method provides a high-efficiency phase retrieval framework and is promising in biomedicine and dynamic observation.

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References

Details

Published: Nov 24, 2021
Vol/Issue: 29(25)
Pages: 41067
License: View

Authors

C

Cheng Shen

California Institute of Technology

J

Jiubin Tan