Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway

Leanne Stevenson; Wendy L. Allen; Irina Proutski; Gail Stewart; Louise Johnston; Karen McCloskey; Peter M. Wilson; Daniel B. Longley; Patrick G. Johnston

doi:10.1371/journal.pone.0020276

journal article Open Access May 24, 2011

Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway

Leanne Stevenson Wendy L. Allen Irina Proutski Gail Stewart Louise Johnston Karen McCloskey

Peter M. Wilson Daniel B. Longley

Patrick G. Johnston

PLoS ONE Vol. 6 No. 5 pp. e20276 · Public Library of Science (PLoS)

View at Publisher Save 10.1371/journal.pone.0020276

Topics

No keywords indexed for this article. Browse by subject →

References

31

[1]

PG Johnston "Capecitabine: A novel agent for the treatment of solid tumors." Anticancer Drugs (2001) 10.1097/00001813-200109000-00001

[2]

JY Douillard "Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial." Lancet (2000) 10.1016/s0140-6736(00)02034-1

[3]

S Giacchetti "Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer." J Clin Oncol (2000) 10.1200/jco.2000.18.1.136

[4]

Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer

David Cunningham, Yves Humblet, Salvatore Siena et al.

New England Journal of Medicine 2004 10.1056/nejmoa033025

[5]

F Caponigro "Monoclonal antibodies targeting epidermal growth factor receptor and vascular endothelial growth factor with a focus on head and neck tumors." Curr Opin Oncol (2005) 10.1097/01.cco.0000159623.68506.cf

[6]

HI Hurwitz "Bevacizumab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer." J Clin Oncol (2005) 10.1200/jco.2005.10.017

[7]

NJ Hack "Developmental changes in the subcellular localization of calretinin." J Neurosci (2000) 10.1523/jneurosci.20-07-j0001.2000

[8]

B Schwaller "Comparison of the Ca2+-binding properties of human recombinant calretinin-22k and calretinin." J Biol Chem (1997) 10.1074/jbc.272.47.29663

[9]

S Bertschy "Selective immunocytochemical localisation of calretinin in the human ovary." Histochem Cell Biol (1998) 10.1007/s004180050202

[10]

V Gotzos "Selective distribution of calretinin in adenocarcinomas of the human colon and adjacent tissues." Am J Surg Pathol (1999) 10.1097/00000478-199906000-00010

[11]

V Gotzos "Heterogeneity of expression of the calcium-binding protein calretinin in human colonic cancer cell lines." Anticancer Res (1996)

[12]

C Doglioni "Calretinin: A novel immunocytochemical marker for mesothelioma." Am J Surg Pathol (1996) 10.1097/00000478-199609000-00001

[13]

AY Chu "Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma." Mod Pathol (2005) 10.1038/modpathol.3800259

[14]

S Schurmans "Impaired long-term potentiation induction in dentate gyrus of calretinin-deficient mice." Proc Natl Acad Sci U S A (1997) 10.1073/pnas.94.19.10415

[15]

D Boehning "Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis." Nat Cell Biol (2003) 10.1038/ncb1063

[16]

MP Mattson "Calcium orchestrates apoptosis." Nat Cell Biol (2003) 10.1038/ncb1203-1041

[17]

Y Wu "Chemotherapeutic Sensitization by Endoplasmic Reticulum Stress: Increasing the Efficacy of Taxane Against Prostate Cancer." Cancer Biol Ther (2009) 10.4161/cbt.8.2.7087

[18]

J Boyer "Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer." Cancer Res (2006) 10.1158/0008-5472.can-05-2693

[19]

DB Longley "c-FLIP inhibits chemotherapy-induced colorectal cancer cell death." Oncogene (2006) 10.1038/sj.onc.1209122

[20]

J Boyer "Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan." Clin Cancer Res (2004) 10.1158/1078-0432.ccr-03-0362

[21]

E Staub "An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types." J Mol Med (2009) 10.1007/s00109-009-0467-y

[22]

M Chanrion "A gene expression signature that can predict the recurrence of tamoxifen-treated primary breast cancer." Clin Cancer Res (2008) 10.1158/1078-0432.ccr-07-1833

[23]

DB Longley "The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates." Cancer Res (2002)

[24]

F Bunz "Disruption of p53 in human cancer cells alters the responses to therapeutic agents." J Clin Invest (1999) 10.1172/jci6863

[25]

L Zhang "Role of BAX in the apoptotic response to anticancer agents." Science (2000) 10.1126/science.290.5493.989

[26]

TR Wilson "Combined inhibition of FLIP and XIAP induces Bax-independent apoptosis in type II colorectal cancer cells." Oncogene (2009) 10.1038/onc.2008.366

[27]

P Liston "The inhibitors of apoptosis: there is more to life than Bcl2." Oncogene (2003) 10.1038/sj.onc.1207101

[28]

C D'Orlando "Calretinin and calbindin D-28k delay the onset of cell death after excitotoxic stimulation in transfected P19 cells." Brain Res (2001) 10.1016/s0006-8993(01)02671-3

[29]

C D'Orlando "Calretinin and calbindin D-28k, but not parvalbumin protect against glutamate-induced delayed excitotoxicity in transfected N18-RE 105 neuroblastoma-retina hybrid cells." Brain Res (2002) 10.1016/s0006-8993(02)02753-1

[30]

J Kuźnicki "The expression of calretinin in transfected PC12 cells provides no protection against Ca(2+)-overload or trophic factor deprivation." Biochim Biophys Acta (1996) 10.1016/0167-4889(96)00089-4

[31]

G Kroemer "Mitochondrial control of cell death." Nat Med (2000) 10.1038/74994

Metrics

45

Citations

31

References

Details

Published: May 24, 2011
Vol/Issue: 6(5)
Pages: e20276
License: View

Authors

Patrick G Johnston Centre for Cancer Research, Queen’s University Belfast, Belfast, Northern Ireland BT9 7BL, United Kingdom;

I

Irina Proutski

1Cancer Research UK Centre for Oncology and Applied Pharmacology, Beatson Laboratories, University of Glasgow, and

School of Medicine, Dentistry and Biomedical Sciences, Centre for Cancer Research and Cell Biology Queen's University Belfast Belfast Northern Ireland UK

Cite This Article

Leanne Stevenson, Wendy L. Allen, Irina Proutski, et al. (2011). Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway. PLoS ONE, 6(5), e20276. https://doi.org/10.1371/journal.pone.0020276

Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway

You May Also Like