The crucial roles of inflammatory mediators in inflammation: A review

L. A. Abdulkhaleq; M. A. Assi; Rasedee Abdullah; M. Zamri-Saad; Y. H. Taufiq-Yap; M. N. M. Hezmee

doi:10.14202/vetworld.2018.627-635

journal article Open Access May 01, 2018

The crucial roles of inflammatory mediators in inflammation: A review

L. A. Abdulkhaleq M. A. Assi Rasedee Abdullah M. Zamri-Saad Y. H. Taufiq-Yap M. N. M. Hezmee

Veterinary World Vol. 11 No. 5 pp. 627-635 · Veterinary World

View at Publisher Save 10.14202/vetworld.2018.627-635

Topics

No keywords indexed for this article. Browse by subject →

References

45

[1]

Anestopoulos, I., Voulgaridou, G. P., Georgakilas, A. G., Franco, R., Pappa, A., and Panayiotidis, M. I. (2015). Epigenetic therapy as a novel approach in hepatocellular carcinoma. Pharmacol. Ther. 145, 103–119. doi: 10.1016/j.pharmthera.2014.09.005 PMID:NOPMID 10.1016/j.pharmthera.2014.09.005

[2]

Arany, Z., Foo, S. Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., et al. (2008). HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1 alpha. Nature 451, 1008–1012. doi: 10.1038/nature06613 PMID:18288196 10.1038/nature06613

[3]

Bataller, R., and Brenner, D. A. (2005). Liver fibrosis. J. Clin. Invest. 115, 209–218. doi: 10.1172/JCI24282 PMID:15690074 10.1172/jci24282

[4]

Bian, E. B., Huang, C., Wang, H., Chen, X. X., Zhang, L., Lv, X. W., et al. (2014). Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Toxicol. Lett. 224, 175–185. doi: 10.1016/j.toxlet.2013.10.038 PMID:24211420 10.1016/j.toxlet.2013.10.038

[5]

Bian, E. B., Wang, Y. Y., Yang, Y., Wu, B. M., Xu, T., Meng, X. M., et al. (2017). Hotair facilitates hepatic stellate cells activation and fibrogenesis in the liver. Biochim. Biophys. Acta 1863, 674–686. doi: 10.1016/j.bbadis.2016.12.009 PMID:27979710 10.1016/j.bbadis.2016.12.009

[6]

Cai, S. P., Cheng, X. Y., Chen, P. J., Pan, X. Y., Xu, T., Huang, C., et al. (2016). Transmembrane protein 88 attenuates liver fibrosis by promoting apoptosis and reversion of activated hepatic stellate cells. Mol. Immunol. 80, 58–67. doi: 10.1016/j.molimm.2016.11.002 PMID:27833039 10.1016/j.molimm.2016.11.002

[7]

Cebola, I., Custodio, J., Munoz, M., Diez-Villanueva, A., Pare, L., Prieto, P., et al. (2015). Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer. Clin. Epigenet. 7:74. doi: 10.1186/s13148-015-0110-4 PMID:26207152 10.1186/s13148-015-0110-4

[8]

Chen, P. J., Cai, S. P., Yang, Y., Li, W. X., Huang, C., Meng, X. M., et al. (2016). PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells. Toxicol. Appl. Pharmacol. 292, 8–18. doi: 10.1016/j.taap.2015.12.021 PMID:26739621 10.1016/j.taap.2015.12.021

[9]

Cho, S. A., Rohn-Glowacki, K. J., Jarrar, Y. B., Yi, M., Kim, W. Y., Shin, J. G., et al. (2015). Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans. Arch. Biochem. Biophys. 569, 10–18. doi: 10.1016/j.abb.2015.01.012 PMID:25623425 10.1016/j.abb.2015.01.012

[10]

Ellis, E. L., and Mann, D. A. (2012). Clinical evidence for the regression of liver fibrosis. J. Hepatol. 56, 1171–1180. doi: 10.1016/j.jhep.2011.09.024 PMID:22245903 10.1016/j.jhep.2011.09.024

[11]

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

Scott L. Friedman

Physiological Reviews 10.1152/physrev.00013.2007

[12]

Friedman, S. L. (2008b). Mechanisms of hepatic fibrogenesis. Gastroenterology 134, 1655–1669. doi: 10.1053/j.gastro.2008.03.003 PMID:NOPMID 10.1053/j.gastro.2008.03.003

[13]

Frigola, J., Munoz, M., Clark, S. J., Moreno, V., Capella, G., and Peinado, M. A. (2005). Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy. Oncogene 24, 7320–7326. doi: 10.1038/sj.onc.1208883 PMID:16007128 10.1038/sj.onc.1208883

[14]

Gao, G. P., Alvira, M. R., Wang, L., Calcedo, R., Johnston, J., and Wilson, J. M. (2002). Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc. Natl. Acad. Sci. U.S.A. 99, 11854–11859. doi: 10.1073/pnas.182412299 PMID:12192090 10.1073/pnas.182412299

[15]

Gupta, R. A., Tan, J., Krause, W. F., Geraci, M. W., Willson, T. M., Dey, S. K., et al. (2000). Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. Proc. Natl. Acad. Sci. U.S.A. 97, 13275–13280. doi: 10.1073/pnas.97.24.13275 PMID:11087869 10.1073/pnas.97.24.13275

[16]

Hatae, T., Wada, M., Yokoyama, C., Shimonishi, M., and Tanabe, T. (2001). Prostacyclin-dependent apoptosis mediated by PPAR delta. J. Biol. Chem. 276, 46260–46267. doi: 10.1074/jbc.M107180200 PMID:11551955 10.1074/jbc.m107180200

[17]

Hellerbrand, C., Stefanovic, B., Giordano, F., Burchardt, E. R., and Brenner, D. A. (1999). The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. J. Hepatol. 30, 77–87. doi: NODOI PMID:9927153 10.1016/s0168-8278(99)80010-5

[18]

Hernandez-Gea, V., and Friedman, S. L. (2011). Pathogenesis of liver fibrosis. Annu. Rev. Pathol. 6, 425–456. doi: 10.1146/annurev-pathol-011110-130246 PMID:21073339 10.1146/annurev-pathol-011110-130246

[19]

Jiao, J., Friedman, S. L., and Aloman, C. (2009). Hepatic fibrosis. Curr. Opin. Gastroenterol. 25, 223–229. doi: NODOI PMID:19396960 10.1097/mog.0b013e3283279668

[20]

Keith, R. L., Miller, Y. E., Hoshikawa, Y., Moore, M. D., Gesell, T. L., Gao, B., et al. (2002). Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer. Cancer Res. 62, 734–740. doi: NODOI PMID:11830527

[21]

Keith, R. L., Miller, Y. E., Hudish, T. M., Girod, C. E., Sotto-Santiago, S., Franklin, W. A., et al. (2004). Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice. Cancer Res. 64, 5897–5904. doi: 10.1158/0008-5472.CAN-04-1070 PMID:15313935 10.1158/0008-5472.can-04-1070

[22]

Mallat, A., and Lotersztajn, S. (2013). Cellular mechanisms of tissue fibrosis. 5. Novel insights into liver fibrosis. Am. J. Physiol. Cell Physiol. 305, C789–C799. doi: 10.1152/ajpcell.00230.2013 PMID:23903700 10.1152/ajpcell.00230.2013

[23]

McCarty, D. M. (2008). Self-complementary AAV vectors; advances and applications. Mol. Ther. J. Am. Soc. Gene Ther. 16, 1648–1656. doi: 10.1038/mt.2008.171 PMID:18682697 10.1038/mt.2008.171

[24]

Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo

D M McCarty, H Fu, P E Monahan et al.

Gene Therapy 10.1038/sj.gt.3302134

[25]

Mizukami, Y., Li, J., Zhang, X., Zimmer, M. A., Iliopoulos, O., and Chung, D. C. (2004). Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 64, 1765–1772. doi: NODOI PMID:14996738 10.1158/0008-5472.can-03-3017

[26]

Moreira, R. K. (2007). Hepatic stellate cells and liver fibrosis. Arch. Pathol. Lab. Med. 131, 1728–1734. doi: NODOI PMID:NOPMID 10.5858/2007-131-1728-hscalf

[27]

Paz, M. F., Wei, S., Cigudosa, J. C., Rodriguez-Perales, S., Peinado, M. A., Huang, T. H., et al. (2003). Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. Hum. Mol. Genet. 12, 2209–2219. doi: 10.1093/hmg/ddg226 PMID:12915469 10.1093/hmg/ddg226

[28]

Pellicoro, A., Ramachandran, P., Iredale, J. P., and Fallowfield, J. A. (2014). Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat. Rev. Immunol. 14, 181–194. doi: 10.1038/nri3623 PMID:24566915 10.1038/nri3623

[29]

Phillips, R. J., Fortier, M. A., and Lopez Bernal, A. (2014). Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation. BMC Pregnancy Childbirth 14:241. doi: 10.1186/1471-2393-14-241 PMID:25048443 10.1186/1471-2393-14-241

[30]

Popper, H., and Uenfriend, S. (1970). Hepatic fibrosis. Correlation of biochemical and morphologic investigations. Am. J. Med. 49, 707–721. doi: NODOI PMID:NOPMID 10.1016/s0002-9343(70)80135-8

[31]

Pradono, P., Tazawa, R., Maemondo, M., Tanaka, M., Usui, K., Saijo, Y., et al. (2002). Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. Cancer Res. 62, 63–66. doi: NODOI PMID:11782360

[32]

Rippe, R. A., and Brenner, D. A. (2004). From quiescence to activation: gene regulation in hepatic stellate cells. Gastroenterology 127, 1260–1262. doi: NODOI PMID:NOPMID 10.1053/j.gastro.2004.08.028

[33]

Sacchi, P., Cima, S., Zuccaro, V., Columpsi, P., Sarda, C., Mariani, M., et al. (2015). Understanding the mechanisms of fibrogenesis in HIV/HCV-coinfected patients: implications for clinical practice. AIDS Rev. 17, 159–170. doi: NODOI PMID:26450804

[34]

Sadler, T., Bhasin, J. M., Xu, Y., Barnholz-Sloan, J., Chen, Y., Ting, A. H., et al. (2016). Genome-wide analysis of DNA methylation and gene expression defines molecular characteristics of Crohn's disease-associated fibrosis. Clin. Epigenetics 8:30. doi: 10.1186/s13148-016-0193-6 PMID:26973718 10.1186/s13148-016-0193-6

[35]

Senoo, H., Imai, K., Matano, Y., and Sato, M. (1998). Molecular mechanisms in the reversible regulation of morphology, proliferation and collagen metabolism in hepatic stellate cells by the three-dimensional structure of the extracellular matrix. J. Gastroenterol. Hepatol. 13(Suppl.), S19–S32. doi: NODOI Epub 1998/10/29. PubMed PMID: 9792031 10.1111/jgh.1998.13.s1.19

[36]

Subramaniam, D., Thombre, R., Dhar, A., and Anant, S. (2014). DNA methyltransferases: a novel target for prevention and therapy. Front. Oncol. 4:80. doi: 10.3389/fonc.2014.00080 PMID:24822169 10.3389/fonc.2014.00080

[37]

Trautwein, C., Friedman, S. L., Schuppan, D., and Pinzani, M. (2015). Hepatic fibrosis: concept to treatment. J. Hepatol. 62(Suppl. 1), S15–S24. doi: 10.1016/j.jhep.2015.02.039 PMID:25920084 10.1016/j.jhep.2015.02.039

[38]

Troeger, J. S., Mederacke, I., Gwak, G. Y., Dapito, D. H., Mu, X., Hsu, C. C., et al. (2012). Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. Gastroenterology 143, 1073–1083.e22. doi: 10.1053/j.gastro.2012.06.036 PMID:22750464 10.1053/j.gastro.2012.06.036

[39]

Tuder, R. M., Cool, C. D., Geraci, M. W., Wang, J., Abman, S. H., Wright, L., et al. (1999). Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am. J. Respir. Crit. Care Med. 159, 1925–1932. doi: 10.1164/ajrccm.159.6.9804054 PMID:10351941 10.1164/ajrccm.159.6.9804054

[40]

Wang, J., Ikeda, R., Che, X. F., Ooyama, A., Yamamoto, M., Furukawa, T., et al. (2013). VEGF expression is augmented by hypoxia-induced PGIS in human fibroblasts. Int. J. Oncol. 43, 746–754. doi: 10.3892/ijo.2013.1994 PMID:23807031 10.3892/ijo.2013.1994

[41]

Wang, Z., Ma, H. I., Li, J., Sun, L., Zhang, J., and Xiao, X. (2003). Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo. Gene Ther. 10, 2105–2111. doi: 10.1038/sj.gt.3302133 PMID:14625564 10.1038/sj.gt.3302133

[42]

Wu, K. K., and Liou, J. Y. (2009). Cyclooxygenase inhibitors induce colon cancer cell apoptosis Via PPARdelta --  14-3-3epsilon pathway. Methods Mol. Biol. 512, 295–307. doi: 10.1007/978-1-60327-530-9_16 PMID:19347284 10.1007/978-1-60327-530-9_16

[43]

Wu, Y., Bu, F., Yu, H., Li, W., Huang, C., Meng, X., et al. (2017). Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis. Toxicol. Appl. Pharmacol. 315, 35–49. doi: 10.1016/j.taap.2016.12.002 PMID:27939986 10.1016/j.taap.2016.12.002

[44]

Yokoyama, C., Yabuki, T., Inoue, H., Tone, Y., Hara, S., Hatae, T., et al. (1996). Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity. Genomics 36, 296–304. doi: 10.1006/geno.1996.0465 PMID:8812456 10.1006/geno.1996.0465

[45]

Zhang, K., Han, X., Zhang, Z., Zheng, L., Hu, Z., Yao, Q., et al. (2017). The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGF beta and Notch pathways. Nat. Commun. 8:144. doi: 10.1038/s41467-017-00204-4 PMID:28747678 10.1038/s41467-017-00204-4

Cited By

625

Lentinula edodes Cultured Extract Intake at Puberty Mitigates Inflammatory Signals at the Mammary Glands by the Involvement of Epigenetic Mechanisms in BALB/c Mice

Hamed Yasavoli-Sharahi, Roghayeh Shahbazi · 2026

The Breast Journal

The therapeutic window: timing dentoalveolar surgery to minimize MRONJ risk in denosumab-treated osteoporotic patients

Daya Masri, Eli Rosenfeld · 2026

JBMR Plus

Aryl-Cyclohexanone as a Potential CB2 Agonist: In Vitro and In Silico Evidence in Inflammatory Modulation

Tainá Larissa Lubschinski, Luiz Antonio Escorteganha Pollo · 2026

Immunopharmacology and Immunotoxico...

Enzyme-Based Anti-Inflammatory Therapeutics for Inflammatory Diseases

Kannan Badri Narayanan · 2025

Pharmaceutics

Bark Extracts of Chamaecyparis obtusa (Siebold & Zucc.) Endl. Attenuate LPS-Induced Inflammatory Responses in RAW264.7 Macrophages

Bo-Ae Kim, Ji-A Byeon · 2025

Plants

Enhanced anti-inflammatory activity of 4-piperidone-based curcumin analogues: structure–activity relationships and mechanistic insights

Zi Han Loh, Ibrahim Jantan · 2025

Phytochemistry Reviews

Surgery-Induced Neutrophil Extracellular Traps Promote Tumor Metastasis by Reprogramming Cancer Cell Lipid Metabolism

Tony Haykal, Ruiqi Yang · 2025

Cancer Research

Exploring the Association Between Immune Cell Phenotypes and Osteoporosis Mediated by Inflammatory Cytokines: Insights from GWAS and Single-Cell Transcriptomics

Shouxiang Kuang, Xiaoqing Ma · 2025

ImmunoTargets and Therapy

Coumarin: A natural solution for alleviating inflammatory disorders

Farnoosh Saadati, Amir Modarresi Chahardehi · 2024

Current Research in Pharmacology an...

Turmeric: from spice to cure. A review of the anti-cancer, radioprotective and anti-inflammatory effects of turmeric sourced compounds

Mihai Cozmin, Ionut Iulian Lungu · 2024

Frontiers in Nutrition

Exploring the interplay between inflammation and male fertility

Oleksandra Fomichova, Pedro F. Oliveira · 2024

The FEBS Journal

Black Cumin Seed (Nigella sativa) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms

Hager K. Rashwan, Shahenda Mahgoub · 2023

Drugs and Drug Candidates

Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators

Nusrath Yasmeen, Harikrishnan Selvaraj · 2023

Biochemical Pharmacology

Silk Fibroin Biomaterials and Their Beneficial Role in Skin Wound Healing

Łukasz Mazurek, Mateusz Szudzik · 2022

Biomolecules

Educational Case: Burn Injury—Pathophysiology, Classification, and Treatment

Seth I. Noorbakhsh, Eric M. Bonar · 2021

Academic Pathology

A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents

Bibi Marjan Razavi, Mahboobeh Ghasemzadeh Rahbardar · 2021

Phytotherapy Research

Recent advancements in the development of heterocyclic anti-inflammatory agents

Sahil Sharma, Devendra Kumar · 2020

European Journal of Medicinal Chemi...

Anti-Inflammatory Activity and ROS Regulation Effect of Sinapaldehyde in LPS-Stimulated RAW 264.7 Macrophages

Seung-Hwa Baek, Tamina Park · 2020

Molecules

LncRNA-GAS5 Inhibits Expression of miR 103 and Ameliorates the Articular Cartilage in Adjuvant-Induced Arthritis in Obese Mice

Hongwei Chen, Chuan He · 2020

Dose-Response

Metrics

625

Citations

45

References

Details

Published: May 01, 2018
Vol/Issue: 11(5)
Pages: 627-635
License: View

Authors

Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 Serdang, Malaysia

Cite This Article

L. A. Abdulkhaleq, M. A. Assi, Rasedee Abdullah, et al. (2018). The crucial roles of inflammatory mediators in inflammation: A review. Veterinary World, 11(5), 627-635. https://doi.org/10.14202/vetworld.2018.627-635

The crucial roles of inflammatory mediators in inflammation: A review

You May Also Like