Glucokinase activators — a promising class of antidiabetic drugs

Alexander A. Spasov; Vadim A. Kosolapov; Denis A. Babkov; Olga Yu. Mayka

doi:10.14341/probl8747

journal article Open Access Jul 17, 2018

Glucokinase activators — a promising class of antidiabetic drugs

Alexander A. Spasov

Vadim A. Kosolapov

Denis A. Babkov

Olga Yu. Mayka

Problems of Endocrinology Vol. 64 No. 3 pp. 180-187 · Endocrinology Research Centre

View at Publisher Save 10.14341/probl8747

Abstract

Type 2 diabetes mellitus is an urgent problem of the modern healthcare. Despite a wide choice of oral hypoglycemic drugs, today there is a great need to create and introduce into clinical practice new, effective, and safe drugs for the treatment of diabetes. One of the promising targets for the creation of new antidiabetics is a glucokinase. It has an exceptionally high influence on glucose homeostasis, serving as a glucose “sensor” in pancreatic β-cells and controlling the rate of glycogen synthesis in the liver. In the present work, the molecular-genetic structure of the enzyme, as well as its interrelation with the organs and tissues of the organism, is presented. The modern ideas about activators of glucokinase as a promising class of antidiabetic drugs are outlined, their hypoglycemic and general antidiabetic effects proved in preclinical and clinical studies are considered. The most advanced activators of glucokinase, undergoing clinical trials, are indicated.

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[1]

10.1016/j.ejmech.2017.03.042

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Details

Published: Jul 17, 2018
Vol/Issue: 64(3)
Pages: 180-187
License: View

Authors

A

Alexander A. Spasov

Department of Pharmacology and Bioinformatics, Volgograd State Medical University, 1 Pavshikh Bortsov sq., 400131 Volgograd, Russia; Volgograd Medical Research Center, 1 Pavshikh Bortsov sq., 400131 Volgograd, Russia

Cite This Article

Alexander A. Spasov, Vadim A. Kosolapov, Denis A. Babkov, et al. (2018). Glucokinase activators — a promising class of antidiabetic drugs. Problems of Endocrinology, 64(3), 180-187. https://doi.org/10.14341/probl8747

Glucokinase activators — a promising class of antidiabetic drugs

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