Effect of acute resistance exercise on bone turnover in young adults before and after concurrent resistance and interval training

Kristen J. Koltun; Adam J. Sterczala; Nicole M. Sekel; Kellen T. Krajewski; Brian J. Martin; Mita Lovalekar; Christopher Connaboy; Shawn D. Flanagan; Sophie L. Wardle; Thomas J. O'Leary; Julie P. Greeves; BRADLEY C. NINDL

doi:10.14814/phy2.15906

journal article Open Access Jan 31, 2024

Effect of acute resistance exercise on bone turnover in young adults before and after concurrent resistance and interval training

Kristen J. Koltun

Adam J. Sterczala

Nicole M. Sekel Kellen T. Krajewski

Brian J. Martin Mita Lovalekar

Christopher Connaboy

Shawn D. Flanagan

Sophie L. Wardle Thomas J. O'Leary

Julie P. Greeves BRADLEY C. NINDL

Physiological Reports Vol. 12 No. 3 · Wiley

View at Publisher Save 10.14814/phy2.15906

Abstract

AbstractWeight‐bearing physical activity can stimulate bone adaptation. This investigation explored the effect of an acute bout of resistance exercise before and after resistance+interval training on circulating biomarkers of bone metabolism and muscle‐bone crosstalk. Healthy young male and female participants (n = 21 male, 28 ± 4 years; n = 17 female, 27 ± 5 years) performed a 6 × 10 squat test (75% 1RM) before and after a 12‐week resistance+interval training program. Before and after completion of the training program, blood samples were collected at rest, immediately postexercise, and 2 h postexercise. Blood samples were analyzed for βCTX, P1NP, sclerostin, osteocalcin, IGF‐1, and irisin. Significant effects of acute exercise (main effect of time) were observed as increases in concentrations of IGF‐1, irisin, osteocalcin, and P1NP from rest to postexercise. A sex*time interaction indicated a greater decline in βCTX concentration from rest to 2 h postexercise and a greater increase in sclerostin concentration from rest to immediately postexercise in male compared with female participants. Sex differences (main effect of sex) were also observed for irisin and P1NP concentrations. In summary, changes in concentrations of biochemical markers of bone metabolism and muscle‐bone crosstalk were observed in males and females after an acute bout of resistance exercise and following 12 weeks of resistance+interval training.

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Details

Published: Jan 31, 2024
Vol/Issue: 12(3)
License: View

Authors

K

Kristen J. Koltun

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

A

Adam J. Sterczala

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

N

Nicole M. Sekel

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

K

Kellen T. Krajewski

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

B

Brian J. Martin

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

M

Mita Lovalekar

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

C

Christopher Connaboy

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

S

Shawn D. Flanagan

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

S

Sophie L. Wardle

Army Health and Performance Research Andover UK

T

Thomas J. O'Leary

Army Health and Performance Research Andover UK

J

Julie P. Greeves

Army Health and Performance Research Andover UK

B

BRADLEY C. NINDL

Department of Sports Medicine and Nutrition, Neuromuscular Research Laboratory/Warrior Human Performance Research Center University of Pittsburgh Pittsburgh Pennsylvania USA

Cite This Article

Kristen J. Koltun, Adam J. Sterczala, Nicole M. Sekel, et al. (2024). Effect of acute resistance exercise on bone turnover in young adults before and after concurrent resistance and interval training. Physiological Reports, 12(3). https://doi.org/10.14814/phy2.15906

Effect of acute resistance exercise on bone turnover in young adults before and after concurrent resistance and interval training

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