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journal article Open Access Jan 22, 2014

δ-Opioid and Dopaminergic Processes in Accumbens Shell Modulate the Cholinergic Control of Predictive Learning and Choice

Vincent Laurent Jesus Bertran-Gonzalez Billy C. Chieng Bernard W. Balleine
The Journal of Neuroscience Vol. 34 No. 4 pp. 1358-1369 · Society for Neuroscience
View at Publisher Save 10.1523/jneurosci.4592-13.2014
Abstract
Decision-making depends on the ability to extract predictive information from the environment to guide future actions. Outcome-specific Pavlovian-instrumental transfer (PIT) provides an animal model of this process in which a stimulus predicting a particular outcome biases choice toward actions earning that outcome. Recent evidence suggests that cellular adaptations of δ-opioid receptors (DORs) on cholinergic interneurons (CINs) in the nucleus accumbens shell (NAc-S) are necessary for PIT. Here we found that modulation of DORs in CINs critically influences D1-receptor (D1R)-expressing projection neurons in the NAc-S to promote PIT. First, we assessed PIT-induced changes in signaling processes in dopamine D1- and D2-receptor-expressing neurons usingdrd2-eGFP mice, and found that PIT-related signaling was restricted to non-D2R-eGFP-expressing neurons, suggesting major involvement of D1R-neurons. Next we confirmed the role of D1Rs pharmacologically: the D1R antagonist SCH-23390, but not the D2R antagonist raclopride, infused into the NAc-S abolished PIT in rats, an effect that depended on DOR activity. Moreover, asymmetrical infusion of SCH-23390 and the DOR antagonist naltrindole into the NAc-S also abolished PIT. DOR agonists were found to sensitize the firing responses of CINs in brain slices prepared immediately after the PIT test. We confirmed the opioid-acetylcholinergic influence over D1R-neurons by selectively blocking muscarinic M4 receptors in the NAc-S, which tightly regulate the activity of D1Rs, a treatment that rescued the deficit in PIT induced by naltrindole. We describe a model of NAc-S function in which DORs modulate CINs to influence both D1R-neurons and stimulus-guided choice between goal-directed actions.
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References
49
[5]
Bolam "Synapses of identified neurons in the neostriatum" Ciba Found Symp (1984)
[9]
Corbit "The role of the nucleus accumbens in instrumental conditioning: evidence of a functional dissociation between accumbens core and shell" J Neurosci (2001) 10.1523/jneurosci.21-09-03251.2001
[11]
Motivational control of goal-directed action

Anthony Dickinson, Bernard Balleine

Animal Learning & Behavior 10.3758/bf03199951
[15]
Modulation of Striatal Projection Systems by Dopamine

Charles R. Gerfen, D. James Surmeier

Annual Review of Neuroscience 10.1146/annurev-neuro-061010-113641
[16]
Goldberg JA Ding JB Surmeier DJ (2012) Muscarinic modulation of striatal function and circuitry. Handb Exp Pharmacol, 223–241. 10.1007/978-3-642-23274-9_10
[18]
Pavlovian to instrumental transfer: A neurobehavioural perspective

Nathan M. Holmes, Alain R. Marchand, Etienne Coutureau

Neuroscience & Biobehavioral Reviews 10.1016/j.neubiorev.2010.03.007
[33]
Paxinos G Watson C (2006) The rat brain in stereotaxic coordinates: hard cover edition (Academic, San Francisco).
[47]
Valjent "Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties" J Neurosci (2000) 10.1523/jneurosci.20-23-08701.2000
Metrics
60
Citations
49
References
Details
Published
Jan 22, 2014
Vol/Issue
34(4)
Pages
1358-1369
License
View
Authors
V
Vincent Laurent
J
Jesus Bertran-Gonzalez
B
Billy C. Chieng
B
Bernard W. Balleine
Cite This Article
Vincent Laurent, Jesus Bertran-Gonzalez, Billy C. Chieng, et al. (2014). δ-Opioid and Dopaminergic Processes in Accumbens Shell Modulate the Cholinergic Control of Predictive Learning and Choice. The Journal of Neuroscience, 34(4), 1358-1369. https://doi.org/10.1523/jneurosci.4592-13.2014
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