SLC
                    1A3 contributes to L‐asparaginase resistance in solid tumors

Jianhui Sun; Remco Nagel; Esther A Zaal; Alejandro Piñeiro Ugalde; Ruiqi Han; Natalie Proost; Ji‐Ying Song; Abhijeet Pataskar; Artur Burylo; Haigen Fu; Gerrit J Poelarends; Marieke van de Ven; Olaf van Tellingen; Celia R Berkers; Reuven Agami

doi:10.15252/embj.2019102147

journal article Open Access Sep 16, 2019

SLC 1A3 contributes to L‐asparaginase resistance in solid tumors

Remco Nagel Esther A Zaal Alejandro Piñeiro Ugalde Ruiqi Han Natalie Proost Ji‐Ying Song Abhijeet Pataskar Artur Burylo Haigen Fu Gerrit J Poelarends Marieke van de Ven Olaf van Tellingen

Celia R Berkers Reuven Agami

The EMBO Journal Vol. 38 No. 21 · Springer Science and Business Media LLC

View at Publisher Save 10.15252/embj.2019102147

Topics

No keywords indexed for this article. Browse by subject →

References

45

[1]

10.1523/jneurosci.3396-12.2013

[2]

10.1186/s40170-015-0128-2

[3]

10.1016/j.cmet.2018.07.021

[4]

HTSeq—a Python framework to work with high-throughput sequencing data

Simon Anders, Paul Theodor Pyl, Wolfgang Huber

Bioinformatics 10.1093/bioinformatics/btu638

[5]

10.2165/00003088-200544040-00003

[6]

10.1016/j.cmet.2018.09.012

[7]

10.1038/1911114a0

[8]

10.1074/jbc.m109.047910

[9]

10.1182/blood-2013-10-535112

[10]

10.1093/nar/gkp427

[11]

10.1038/leu.2010.256

[12]

10.1002/1097-0142(197002)25:2<279::aid-cncr2820250205>3.0.co;2-7

[13]

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G Doench, Nicolo Fusi, Meagan Sullender et al.

Nature Biotechnology 10.1038/nbt.3437

[14]

10.1038/s41556-018-0118-z

[15]

10.1056/nejm196911062811902

[16]

10.3892/mco.2013.99

[17]

10.1016/j.ccell.2019.03.004

[18]

10.1016/j.mam.2013.01.001

[19]

10.1084/jem.98.6.565

[20]

10.1038/nature25465

[21]

10.1038/nbt.3450

[22]

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

Abigail S. Krall, Shili Xu, Thomas G. Graeber et al.

Nature Communications 10.1038/ncomms11457

[23]

The Sequence Alignment/Map format and SAMtools

Heng Li, Bob Handsaker, Alec Wysoker et al.

Bioinformatics 10.1093/bioinformatics/btp352

[24]

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens

Wei Li, Han Xu, Tengfei Xiao et al.

Genome Biology 10.1186/s13059-014-0554-4

[25]

The landscape of cancer cell line metabolism

Haoxin Li, Shaoyang Ning, Mahmoud Ghandi et al.

Nature Medicine 10.1038/s41591-019-0404-8

[26]

10.1038/nature16982

[27]

10.15252/embr.201744000

[28]

10.1016/s1040-8428(98)00015-8

[29]

10.1073/pnas.1805523115

[30]

10.1186/gb-2010-11-12-220

[31]

10.1016/j.cmet.2017.12.006

[32]

10.1056/nejmoa0900386

[33]

10.1038/nature15529

[34]

Riccardi R "L‐asparaginase pharmacokinetics and asparagine levels in cerebrospinal fluid of rhesus monkeys and humans" Cancer Res (1981)

[35]

A gene expression database for the molecular pharmacology of cancer

Uwe Scherf, Douglas T. Ross, Mark Waltham et al.

Nature Genetics 10.1038/73439

[36]

10.1124/mol.65.4.1008

[37]

10.1182/blood-2002-08-2446

[38]

10.1016/j.cell.2015.07.017

[39]

10.1038/s41556-018-0125-0

[40]

10.1016/j.cmet.2018.07.005

[41]

TopHat: discovering splice junctions with RNA-Seq

Cole Trapnell, Lior Pachter, Steven L. Salzberg

Bioinformatics 10.1093/bioinformatics/btp120

[42]

10.1038/sj.leu.2400834

[43]

10.1016/j.cell.2015.07.027

[44]

10.1016/j.cell.2016.12.039

[45]

10.1038/emboj.2010.81

Metrics

68

Citations

45

References

Details

Published: Sep 16, 2019
Vol/Issue: 38(21)
License: View

Authors

J

Jianhui Sun

Division of Oncogenomics Oncode Institute The Netherlands Cancer Institute Amsterdam The Netherlands; Department of Genetics Erasmus University Medical Center Rotterdam The Netherlands

R

Remco Nagel

Division of Oncogenomics Oncode Institute The Netherlands Cancer Institute Amsterdam The Netherlands

E

Esther A Zaal

Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research Utrecht University Utrecht The Netherlands

A

Alejandro Piñeiro Ugalde

Division of Oncogenomics Oncode Institute The Netherlands Cancer Institute Amsterdam The Netherlands

R

Ruiqi Han

Division of Oncogenomics Oncode Institute The Netherlands Cancer Institute Amsterdam The Netherlands; Department of Genetics Erasmus University Medical Center Rotterdam The Netherlands

N

Natalie Proost

Preclinical Intervention Unit and Pharmacology Unit of the Mouse Clinic for Cancer and Ageing (MCCA) The Netherlands Cancer Institute Amsterdam The Netherlands

J

Ji‐Ying Song

Division of Experimental Animal Pathology The Netherlands Cancer Institute Amsterdam The Netherlands

A

Abhijeet Pataskar

Division of Oncogenomics Oncode Institute The Netherlands Cancer Institute Amsterdam The Netherlands

A

Artur Burylo

Division of Pharmacology The Netherlands Cancer Institute Amsterdam The Netherlands

H

Haigen Fu

Department of Chemical and Pharmaceutical Biology University of Groningen Groningen The Netherlands

G

Gerrit J Poelarends

Department of Chemical and Pharmaceutical Biology University of Groningen Groningen The Netherlands

M

Marieke van de Ven

Preclinical Intervention Unit and Pharmacology Unit of the Mouse Clinic for Cancer and Ageing (MCCA) The Netherlands Cancer Institute Amsterdam The Netherlands

O

Olaf van Tellingen

Division of Pharmacology The Netherlands Cancer Institute Amsterdam The Netherlands

C

Celia R Berkers

Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research Utrecht University Utrecht The Netherlands; Department of Biochemistry and Cell Biology Faculty of Veterinary Medicine Utrecht University Utrecht The Netherlands

R

Reuven Agami

Division of Oncogenomics Oncode Institute The Netherlands Cancer Institute Amsterdam The Netherlands; Department of Genetics Erasmus University Medical Center Rotterdam The Netherlands

Funding

H2020 European Research Council Award: ERC‐PoC 665317

China Scholarship Council Award: 201503250056

Cite This Article

Jianhui Sun, Remco Nagel, Esther A Zaal, et al. (2019). SLC 1A3 contributes to L‐asparaginase resistance in solid tumors. The EMBO Journal, 38(21). https://doi.org/10.15252/embj.2019102147

SLC 1A3 contributes to L‐asparaginase resistance in solid tumors

You May Also Like