Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development

JM Kindblom; O Nilsson; T Hurme; C Ohlsson; L Savendahl

doi:10.1677/joe.0.174r001

journal article Aug 01, 2002

Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development

JM Kindblom O Nilsson T Hurme C Ohlsson L Savendahl

Journal of Endocrinology Vol. 174 No. 2 pp. R1-R6 · Bioscientifica

View at Publisher Save 10.1677/joe.0.174r001

Abstract

Indian Hedgehog (Ihh) has been reported to control the rate of cartilage differentiation during skeletal morphogenesis in rodents through a negative feedback loop involving parathyroid hormone related protein (PTHrP). The role of Ihh and PTHrP in the regulation of human epiphyseal chondrocytes is unknown. The aim of the current study was to examine the expression and localization of Ihh and PTHrP in the human growth plate at various pubertal stages. Growth plate biopsies were obtained from patients subjected to epiphyseal surgery and the expression of Ihh and PTHrP was detected by immunohistochemistry. We show that Ihh and PTHrP are expressed mainly in early hypertrophic chondrocytes in the human growth plate. The levels of expression of Ihh and PTHrP are higher in early stages of puberty than later. Our results suggest that Ihh and PTHrP are present in the human growth plate and that Ihh and PTHrP may be involved in the regulation of pubertal growth in humans.

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Published: Aug 01, 2002
Vol/Issue: 174(2)
Pages: R1-R6

Authors

1Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

L

L Savendahl

Cite This Article

JM Kindblom, O Nilsson, T Hurme, et al. (2002). Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development. Journal of Endocrinology, 174(2), R1-R6. https://doi.org/10.1677/joe.0.174r001

Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development

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