Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure

C Nilsson; D Swolin-Eide; C Ohlsson; E Eriksson; HP Ho; P Bjorntorp; A Holmang

doi:10.1677/joe.0.1760013

journal article Jan 01, 2003

Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure

C Nilsson D Swolin-Eide C Ohlsson E Eriksson HP Ho P Bjorntorp A Holmang

Journal of Endocrinology Vol. 176 No. 1 pp. 13-21 · Bioscientifica

View at Publisher Save 10.1677/joe.0.1760013

Abstract

Leptin is involved in regulating food intake, energy balance and bone formation. Increasing evidence suggests that leptin is also involved in fetal growth and development. The aim of this study was to determine if increased maternal leptin is followed by changes in body composition, skeletal growth or hormonal regulation in the adult rat offspring. Pregnant rats were given injections of either human recombinant leptin (3.5 mg/kg, i.p.) or vehicle on days 8, 10 and 12 of gestation. Both genders of leptin-exposed offspring showed significantly reduced adipose tIssue weight at adult age. Skeletal growth and cortical bone dimensions were significantly reduced. Circulating testosterone levels were significantly increased in female leptin-exposed offspring, and male leptin-exposed offspring had significant testicular enlargement. No significant effects were seen on circulating leptin levels or hypothalamic protein levels of the leptin receptor. The results demonstrate that maternally administered leptin is involved in fetal growth and development, leading to lean offspring with reduced skeletal growth.

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Details

Published: Jan 01, 2003
Vol/Issue: 176(1)
Pages: 13-21

Authors

1Center for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Cite This Article

C Nilsson, D Swolin-Eide, C Ohlsson, et al. (2003). Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure. Journal of Endocrinology, 176(1), 13-21. https://doi.org/10.1677/joe.0.1760013

Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure

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