Electrophysiological Markers of Chemotherapy-Induced Polyneuropathy
The study was aimed at identifying electrophysiological CIPN markers and evaluting their sensitivity and specificity.
Materials and methods. The study included patients (n = 71) over 18 years of age with solid tumor presenting with polyneuritic complaints following neurotoxic therapy with platinum-based agents and taxanes. Patients with known risk factors for polyneuropathy were excluded. Electrophysiological and clinical patient data were evaluated no earlier than 3 months following chemotherapy initiation.
Results. The study identified electromyographic markers: SRAR index (sural/radial ratio — the ratio between the action potential amplitudes of the sural and radial nerves) and the sural nerve action potential (SNAP), demonstrating equal sensitivity (73.7%) and high specificity (75% and 84.6%, respectively).
Conclusion. Electromyographic parameters such as SRAR and SNAP sural nerve can be utilized for the diagnosis and monitoring of CIPN in daily practice.
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- Published
- Jun 26, 2025
- Vol/Issue
- 19(2)
- Pages
- 34-40
- License
- View
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