journal article Sep 15, 2020

To study the level of serum liver enzymes (SGOT & SGPT) in multitransfused thalassemia major patients

View at Publisher Save 10.18231/j.ijmpo.2020.024
Abstract
This study was conducted on 100 children with β-thalassemia major aged between 1-15 years being regularly transfused at Department of Pediatrics, M.G.M. Medical College, after taking the consent from the parents and explaining them the purpose and method of study. Mean serum values of ferritin, SGOT, SGPT was found to be 6416.9 ± 1581.8 μg/l, 205.4 ± 46.3 u/l and 254.6 ± 71.7 u/l in patients who received more than 100 transfusions while it was 3784.2 ±1304 μg/l, 104.9 ± 52.9 u/l, and 131.5 ± 63.6 u/l respectively for those who receive more than 100 transfusions Youngsters with >100 transfusions had serum values of liver enzymes and iron overload higher when contrasted with those with <100 transfusions. The distinction in values between the two gatherings was seen as exceptionally huge (p esteem <0.001) Mean serum estimations of ferritin, SGOT, SGPT was seen as 6416.9 ± 1581.8 μg/l, 205.4 ± 46.3 u/l and 254.6 ± 71.7 u/l in patients who got in excess of 100 transfusions while it was 3784.2 ±1304 μg/l, 104.9 ± 52.9 u/l, and 131.5 ± 63.6 u/l individually for the individuals who get less than 100 transfusions.
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References
14
[1]
Fernandez-Real J M, Penarroja G, Castro A, Bragado F G, Hernandez I, Ricart W, Effects on insulin sensitivity and beta cell function.Diabetes 2002;51:1000-4 10.2337/diabetes.51.4.1000
[2]
Gunshin H, Mackenzie B, Berger U V, Gunshin Y, Romero M F, Boron W F, Cloning and characterization of a mammalian proton-coupled metal-ion transporter.Nat 1997;388(6641):482-8 10.1038/41343
[3]
Gillium R F, Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men:The Third National Health And Nutritional Examination Survey.Int J Obes Rel Metab Dis 2001;25:639-45 10.1038/sj.ijo.0801561
[4]
George E, Wong H B, George R, W A Ariffin, Serum ferritin concentrations in transfusion dependent beta thalassemia.Singapore Med J 1994;35(1):62-4
[5]
Gamberini M R, Fotini M, Gilli G, Testa M R, Sanctis V D, Epidemiology and chelation therapy effects on glucose homeostasis in thalassemic patients.J Pediatr Endocrinol Metab 1998;11(3):867-9
[6]
C Hershko, G Link, Cabantchik I, Pathophysiology of Iron Overloada.Ann N York Acad Sci 1998;856:191-201 10.1111/j.1749-6632.1998.tb10475.x
[7]
Hirayama M, Kohgo Y, Kondo H, Shintani N, Fujikawa K, Sasaki K, Regulation of iron metabolism in HepG2 cells: A possible role for cytokines in the hepatic deposition of iron.Hepatol 1993;18(4):874-80 10.1002/hep.1840180420
[8]
Jacket M B, Balla J, Ball G, Jessurum J, Jacob H S, Vercellotti G M, Ferritin protects endothelial cells from oxidized LDL invitro.Am J Pathol 1995;147:782-9
[9]
Henry R, Standard Methods of clinical chemistry. 1963;4:1-261
[10]
Hemoglobinopathyand thalassemia..
[11]
Chern J P S, Lin M K H, Lu M y, Lin D T, Lin K S, Chan J D, Abnormal glucose tolerance in transfusion dependent beta thalassemia patients.Diabetic Care 2001;24:850-4 10.2337/diacare.24.5.850
[12]
Real R J Fernandez, Engel E R, Arroyo E, Bannca R, Abella R C, Cabrero D, Serum ferritin as a component of the insulin resistance syndrome. Diabetes Care 199821;1:62-8 10.2337/diacare.21.1.62
[13]
Jensen C E, Tuck S M, RW J Old Morris, Wonke A V, Yardumian A, Sanctis V De, Incidence of endocrine complications and clinical disease severity related to genotype analysis and iron overload in patients with beta thalassemia.East Mediterr Health J 2003;9(1-2):55-60
[14]
Mazza P, Giua R, Marco De, Bonetti S, Amurri M G, Masi B, Iron overload in thalassemia; comparative analysis of magnetic resonance imaging, serum ferritin and iron content of the liver.Hematol 1995;80(5):398-404
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Details
Published
Sep 15, 2020
Vol/Issue
6(3)
Pages
107-109
Cite This Article
Prashant Kumar Choudhary, Prachi Goyal (2020). To study the level of serum liver enzymes (SGOT & SGPT) in multitransfused thalassemia major patients. IP International Journal of Medical Paediatrics and Oncology, 6(3), 107-109. https://doi.org/10.18231/j.ijmpo.2020.024