Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals

Darryl Hudson; Igor Kovalchuk; Igor Koturbash; Bryan Kolb; Olga A. Martin; Olga Kovalchuk

doi:10.18632/aging.100340

journal article Jun 18, 2011

Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals

Darryl Hudson Igor Kovalchuk

Igor Koturbash

Bryan Kolb Olga A. Martin Olga Kovalchuk

Aging Vol. 3 No. 6 pp. 609-620 · Impact Journals, LLC

View at Publisher Save 10.18632/aging.100340

Topics

No keywords indexed for this article. Browse by subject →

References

75

[1]

Ward "Radiation mutagenesis: the initial DNA lesions responsible" Radiat Res (1995) 10.2307/3579145

[2]

Little "Radiation carcinogenesis" Carcinogenesis (2000) 10.1093/carcin/21.3.397

[3]

Morgan "Radiation-induced genomic instability and its implications for radiation carcinogenesis" Oncogene (2003)

[4]

Shigemitsu "Leukemia and thyroid carcinoma found among A-bomb survivors in Hiroshima" Recent Results Cancer Res (1972)

[5]

Yamawaki "Incidence of leukemia in survivors of the atomic bomb in Hiroshima and Nagasaki, Japan" Am J Med (1952)

[6]

Schull "Studies of the mortality of A-bomb survivors, report 7. Part III. incidence of cancer in 1959-1978, based on the tumor registry, Nagasaki" Radiat Res (1983)

[7]

Kossenko "Cancer mortality among Techa River residents and their offspring" Health Phys (1996) 10.1097/00004032-199607000-00012

[8]

Kossenko "Cancer mortality in the exposed population of the Techa River area" World Health Stat Q (1996)

[9]

Koshurnikova "Cancer mortality risk among workers at the Mayak nuclear complex" Radiat Res (2003)

[10]

Balonov "The Chernobyl Forum: major findings and recommendations" J Environ Radioact (2007) 10.1016/j.jenvrad.2007.01.015

[11]

Machilo "Malignant diseases of hematopoietic and lymphoid tissues in Chernobyl clean-up workers" Hematol J (2005) 10.1038/sj.thj.6200568

[12]

Dixon "Breast cancer risk among the survivors of atomic bomb and patients exposed to therapeutic ionising radiation" Eur J Surg Oncol (2003)

[13]

Tirmarche "Twenty years after the Chernobyl accident: solid cancer incidence in various groups of the Ukrainian population" Radiat Environ Biophys (2007)

[14]

Cardis "Breast cancer in Belarus and Ukraine after the Chernobyl accident" Int J Cancer (2006)

[15]

Fukushima "Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster" Oncol Rep (2004)

[16]

Fukushima "Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident" Int J Cancer (2000)

[17]

Devesa "Childhood cancer: overview of incidence trends and environmental carcinogens" Environ Health Perspect (1995)

[18]

Mabuchi "Mortality and cancer risk among the offspring (F1) of atomic bomb survivors" J Radiat Res (Tokyo) (1991)

[19]

Little "Risk coefficients for childhood cancer after intrauterine irradiation: a review" Int J Radiat Biol (2003)

[20]

Brill "Childhood cancer 10 years after the Chernobyl accident" Curr Opin Pediatr (1997) 10.1097/00008480-199702000-00012

[21]

McBride "Childhood cancer and environmental contaminants" Can J Public Health (1998)

[22]

Ullrich "Incidence of acute myeloid leukemia and hepatocellular carcinoma in mice irradiated with 1 GeV/nucleon (56)Fe ions" Radiat Res (2009)

[23]

Shimada "Radiation-induced mammary carcinogenesis in rodent models: what's different from chemical carcinogenesis?" J Radiat Res (Tokyo) (2009)

[24]

Bedford "Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma Rays. Part II. Theoretical considerations based on microdosimetry and the initial induction of chromosome aberrations" Radiat Res (2009)

[25]

Fukuda "Dose-response relationship for life-shortening and carcinogenesis in mice irradiated at day 7 postnatal age with dose range below 1 Gy of gamma rays" J Radiat Res (Tokyo) (2006)

[26]

Kasuga "Life-shortening and carcinogenesis in mice irradiated neonatally with X rays" Radiat Res (1981)

[27]

Fukuda "Dose-response relationship for induction of solid tumors in female B6C3F1 mice irradiated neonatally with a single dose of gamma rays" J Radiat Res (Tokyo) (1999)

[28]

Fukuda "Dose-response relationship for lifetime excess mortality and temporal pattern of manifestation in mice irradiated neonatally with gamma rays" J Radiat Res (Tokyo) (2002)

[29]

Fukuda "Temporal variation of excess mortality rate from solid tumors in mice irradiated at various ages with gamma rays" J Radiat Res (Tokyo) (2005)

[30]

Fukuda "Dose-response relationship for induction of ovarian tumors in mice irradiated during prenatal, early postnatal and elder periods" J Radiat Res (Tokyo) (2008)

[31]

Yonekawa "Intestinal tumorigenesis in Min mice is enhanced by X-irradiation in an age-dependent manner" J Radiat Res (Tokyo) (2005)

[32]

Shimada "Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence" Radiat Res (2006)

[33]

Lin "The DNA damage response: Balancing the scale between cancer and ageing" Aging (2010) 10.18632/aging.100248

[34]

Richardson "Ionizing radiation and aging: rejuvenating an old idea" Aging (2009) 10.18632/aging.100081

[35]

Olive "Endogenous DNA breaks: gammaH2AX and the role of telomeres" Aging (2009) 10.18632/aging.100025

[36]

γH2AX and cancer

William M. Bonner, Christophe E. Redon, Jennifer S. Dickey et al.

Nature Reviews Cancer 2008 10.1038/nrc2523

[37]

Iliakis "Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin" Nucleic Acids Res (2008)

[38]

Bonner "DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139" J Biol Chem (1998)

[39]

Nussenzweig "H2AX haploinsufficiency modifies genomic stability and tumor susceptibility" Cell (2003)

[40]

Nussenzweig "Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks" Nat Cell Biol (2003) 10.1038/ncb1004

[41]

Bonner "Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody" Radiat Res (2002)

[42]

Uder "In vivo formation and repair of DNA double-strand breaks after computed tomography examinations" Proc Natl Acad Sci U S A (2005)

[43]

Sedelnikova "gamma-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin" Adv Space Res (2009)

[44]

Bonner "Megabase chromatin domains involved in DNA double-strand breaks in vivo" J Cell Biol (1999)

[45]

Sedelnikova "Where did they come from? The origin of endogenous gamma-H2AX foci in tumor cells" Cell Cycle (2009) 10.4161/cc.8.15.9311

[46]

Bonner "GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence" Cell Cycle (2006) 10.4161/cc.5.24.3569

[47]

Sedelnikova "Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells" Aging (2009) 10.18632/aging.100019

[48]

Lobrich "Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses" Proc Natl Acad Sci U S A (2003)

[49]

Lichten "Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break" Curr Biol (2004)

[50]

Bedford "Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis" J Cell Physiol (2009)

Showing 50 of 75 references

Metrics

45

Citations

75

References

Details

Published: Jun 18, 2011
Vol/Issue: 3(6)
Pages: 609-620

Authors

D

Darryl Hudson

Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada

I

Igor Kovalchuk

Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada

I

Igor Koturbash

Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada; Current address: Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration. AR 72079 USA

B

Bryan Kolb

Department of Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada

O

Olga A. Martin

Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, MD, 20892, USA; Current address: Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, VIC, 8006 Australia

O

Olga Kovalchuk

Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, T1K 3M4 Canada

Cite This Article

Darryl Hudson, Igor Kovalchuk, Igor Koturbash, et al. (2011). Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals. Aging, 3(6), 609-620. https://doi.org/10.18632/aging.100340

Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals

You May Also Like