journal article
Sep 30, 2015
Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results fromin vitroandin vivostudies with bromelain and N-acetylcysteine
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References
48
[1]
Gum "Mucin genes and the proteins they encode: structure, diversity, and regulation" American journal of respiratory cell and molecular biology (1992) 10.1165/ajrcmb/7.6.557
[2]
Pignatelli "Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease" Gut (2000) 10.1136/gut.47.4.589
[3]
Mucins in cancer: protection and control of the cell surface
Michael A. Hollingsworth, Benjamin J. Swanson
Nature Reviews Cancer
2004
10.1038/nrc1251
[4]
Morris "Secreted mucins in pseudomyxoma peritonei: pathophysiological significance and potential therapeutic prospects" Orphanet journal of rare diseases (2014) 10.1186/1750-1172-9-71
[5]
Sugarbaker "Intraperitoneal chemotherapy and its evolving role in management of gastric cancer with peritoneal metastases" Chinese journal of cancer research (2014)
[6]
Sugarbaker "An evolving role of perioperative intraperitoneal chemotherapy after cytoreductive surgery for colorectal peritoneal carcinomatosis" Ann Surg Oncol (2007) 10.1245/s10434-007-9380-1
[7]
Morris "Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells: significance of combination therapy" Journal of experimental & clinical cancer research : CR (2014)
[8]
Mukherjee "MUC1: a multifaceted oncoprotein with a key role in cancer progression" Trends in molecular medicine (2014) 10.1016/j.molmed.2014.02.007
[9]
Soderberg "MUC2 mucin is a major carrier of the cancer-associated sialyl-Tn antigen in intestinal metaplasia and gastric carcinomas" Glycobiology (2010) 10.1093/glycob/cwp161
[10]
Bresalier "Ectopic expression of MUC5 gastric mucin in colorectal adenocarcinoma" Gastroenterology (1998) 10.1016/s0016-5085(98)82329-9
[11]
Young "Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype" Mod Pathol (2013) 10.1038/modpathol.2013.101
[12]
Van Seuningen "Mucins and tumor resistance to chemotherapeutic drugs" Biochim Biophys Acta (2014)
[13]
Morris "A formulation forlysis of mucin secreted in pseudomyxoma peritonei" Int J Cancer (2014) 10.1002/ijc.28380
[14]
Sadowska "N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease" Therapeutic advances in respiratory disease (2012) 10.1177/1753465812437563
[15]
Shih "The add-on N-acetylcysteine is more effective than dimethicone alone to eliminate mucus during narrow-band imaging endoscopy: a double-blind, randomized controlled trial" Scandinavian journal of gastroenterology (2013) 10.3109/00365521.2012.749509
[16]
Hong "Intraductal papillary mucinous neoplasm of the bile duct with gastric and duodenal fistulas" World journal of gastrointestinal endoscopy (2014) 10.4253/wjge.v6.i7.328
[17]
Li "Continuous infusion of N-acetylcysteine by nasobiliary for advanced intraductal papillary mucinous neoplasm of bile ducts (with video)" The American journal of gastroenterology (2012) 10.1038/ajg.2012.338
[18]
Swinney "Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli" American journal of respiratory cell and molecular biology (2006) 10.1165/rcmb.2005-0259oc
[19]
Morcillo "Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen" Eur Respir J (2003) 10.1183/09031936.03.00039602
[20]
Morcillo "Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats" Eur Respir J (2003) 10.1183/09031936.03.00018003
[21]
Moon "Increased oxidative stress in the airway and development of allergic inflammation in a mouse model of asthma" Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology (2009) 10.1016/s1081-1206(10)60188-3
[22]
Jeffery "Oral N-acetylcysteine or S-carboxymethylcysteine inhibit cigarette smoke-induced hypersecretion of mucus in rat larynx and trachea" Eur Respir J (1989) 10.1183/09031936.93.02100955
[23]
Hauber "Dexamethasone and N-acetyl-cysteine attenuate Pseudomonas aeruginosa-induced mucus expression in human airways" Pulmonary pharmacology & therapeutics (2011) 10.1016/j.pupt.2010.11.003
[24]
Fujisawa "Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treatedmodel" Cornea (2004) 10.1097/01.ico.0000126436.25751.fb
[25]
Morris "Potentiation of chemotherapeutics by Bromelain and N-acetylcysteine: Sequential and combination therapy of gastrointestinal cancer cells" American journal of cancer research (2015)
[26]
McGuckin "Improvedmodel systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions" Helicobacter (2007) 10.1111/j.1523-5378.2007.00509.x
[27]
Kahan "Human colon adenocarcinoma cells II. Tumorigenic and organoid expressionand" J Natl Cancer Inst (1977) 10.1093/jnci/58.5.1507
[28]
Einerhand "The human intestinal cell lines Caco-2 and LS174T as models to study cell-type specific mucin expression" Glycoconjugate J (1996) 10.1007/bf00702340
[29]
De Flora "Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine" Int J Cancer (1995) 10.1002/ijc.2910610121
[30]
Albini "Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models" Int J Cancer (1996) 10.1002/(sici)1097-0215(19960917)67:6<842::aid-ijc14>3.0.co;2-3
[31]
Moon "Mouse Melanoma Cell Migration is Dependent on Production of Reactive Oxygen Species under Normoxia Condition" Biomolecules & therapeutics (2012) 10.4062/biomolther.2012.20.2.165
[32]
Bonnefoy "N-acetyl-L-cysteine exhibits antitumoral activity by increasing tumor necrosis factor alpha-dependent T-cell cytotoxicity" Blood (1997) 10.1182/blood.v90.3.1124
[33]
De Flora "Inhibition of angiogenesis-driven Kaposi's sarcoma tumor growth in nude mice by oral N-acetylcysteine" Cancer Res (2001)
[34]
Berger "Induction of the fibrinolytic system by cartilage extract mediates its antiangiogenic effect in mouse glioma" Microvascular research (2011) 10.1016/j.mvr.2011.03.002
[35]
Watson "The antioxidant n-acetylcysteine increases 5-fluorouracil activity against colorectal cancer xenografts in nude mice" J Gastrointest Surg (2001) 10.1016/s1091-255x(01)80018-4
[36]
Huang "N-acetylcysteine (NAC) inhibits cell growth by mediating the EGFR/Akt/HMG box-containing protein 1 (HBP1) signaling pathway in invasive oral cancer" Oral Oncol (2013) 10.1016/j.oraloncology.2012.08.003
[37]
Nieminen "N-acetyl-L-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFkappaB pathway" Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2014) 10.1016/j.biopha.2014.08.007
[38]
Bergo "Antioxidants accelerate lung cancer progression in mice" Science translational medicine (2014)
[39]
Yang "Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine" Carcinogenesis (2002) 10.1093/carcin/23.6.993
[40]
De Flora "Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine" Proc Natl Acad Sci U S A (2006) 10.1073/pnas.0601412103
[41]
Gerard "Oxidative stress: a required condition for thyroid cell proliferation" Am J Pathol (2010) 10.2353/ajpath.2010.090682
[42]
Sur "Inhibiting pollen reduced nicotinamide adenine dinucleotide phosphate oxidase-induced signal by intrapulmonary administration of antioxidants blocks allergic airway inflammation" The Journal of allergy and clinical immunology (2007) 10.1016/j.jaci.2006.11.634
[43]
Cortijo "N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with respiratory syncytial virus (RSV)" Biochem Pharmacol (2011) 10.1016/j.bcp.2011.05.014
[44]
Hernandez "antitumoral activity of stem pineapple (Ananas comosus) bromelain" Planta Med (2007) 10.1055/s-2007-990221
[45]
Borrelli "The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects" Molecular nutrition & food research (2014) 10.1002/mnfr.201300345
[46]
Hickman "Endpoints for mouse abdominal tumor models: refinement of current criteria" Comparative medicine (2009)
[47]
Yeoh "CDX2 expression is progressively decreased in human gastric intestinal metaplasia, dysplasia and cancer" Mod Pathol (2007) 10.1038/modpathol.3800968
[48]
Salter "Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group" J Natl Cancer Inst (2011) 10.1093/jnci/djr393
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Chagasin-based carriers designed for the cancer-targeted release of proteases
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Jyotsna Jai, Xiao Han · 2026
Metrics
32
Citations
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References
Details
- Published
- Sep 30, 2015
- Vol/Issue
- 6(32)
- Pages
- 33329-33344
Authors
Cite This Article
Afshin Amini, Samar Masoumi-Moghaddam, Anahid Ehteda, et al. (2015). Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results fromin vitroandin vivostudies with bromelain and N-acetylcysteine. Oncotarget, 6(32), 33329-33344. https://doi.org/10.18632/oncotarget.5259
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