Factors affecting the degradation of pharmaceuticals in agricultural soils

Sara C. Monteiro; Alistair B. A. Boxall

doi:10.1897/08-657.1

journal article Dec 01, 2009

Factors affecting the degradation of pharmaceuticals in agricultural soils

Sara C. Monteiro Alistair B. A. Boxall

Environmental Toxicology and Chemistry Vol. 28 No. 12 pp. 2546-2554 · Oxford University Press (OUP)

View at Publisher Save 10.1897/08-657.1

Abstract

Abstract
Pharmaceuticals may be released to the soil environment through the application of biosolids to land. To understand those factors affecting the persistence of pharmaceuticals in the soil environment, the present study was performed to assess the effects of soil type, the presence of biosolids, and the impact of chemical mixture interactions on the degradation of three pharmaceuticals: naproxen, carbamazepine, and fluoxetine. Single-compound studies showed that naproxen degraded in a range of soils with half-lives ranging from 3.1 to 6.9 d and in biosolids with a half-life of 10.2 d. No relationships were observed between degradation rate and soil physicochemical properties and soil bioactivity. For naproxen, addition of biosolids to soils reduced the degradation rate observed in the soil-only studies, with half-lives in the soil-biosolid systems ranging from 3.9 to 15.1 d. Carbamazepine and fluoxetine were found to be persistent in soils, biosolids, and soil-biosolid mixtures. When degradation was assessed using a mixture of the three study compounds and the sulfonamide antibiotic sulfamethazine, the degradation behavior of fluoxetine and carbamazepine was similar to that observed in the single compound studies (i.e., no degradation). However, the degradation rate of naproxen in soils, biosolids, and soil-biosolid systems spiked with the mixture was significantly slower than in the single-compound studies. As degradation studies for risk assessment purposes are performed using single substances in soil-only studies, it is possible that current risk assessment procedures will underestimate environmental impacts. Further work is therefore warranted on a larger range of substances, soils, biosolid types, and chemical mixtures to better understand the fate of pharmaceuticals in terrestrial systems.

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Metrics

169

Citations

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References

Details

Published: Dec 01, 2009
Vol/Issue: 28(12)
Pages: 2546-2554
License: View

Authors

S

Sara C. Monteiro

The Food and Environment Research Agency, Sand Hutton, York Y041 1LZ, United Kingdom; Environment Department, University of York, Heslington, York YO10 5DD, United Kingdom

A

Alistair B. A. Boxall

The Food and Environment Research Agency, Sand Hutton, York Y041 1LZ, United Kingdom; Environment Department, University of York, Heslington, York YO10 5DD, United Kingdom

Cite This Article

Sara C. Monteiro, Alistair B. A. Boxall (2009). Factors affecting the degradation of pharmaceuticals in agricultural soils. Environmental Toxicology and Chemistry, 28(12), 2546-2554. https://doi.org/10.1897/08-657.1

Factors affecting the degradation of pharmaceuticals in agricultural soils

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