Inflammation and Factors That May Regulate Inflammatory Response

Thomas E. Van Dyke; Kenneth S. Kornman

doi:10.1902/jop.2008.080239

journal article Aug 01, 2008

Inflammation and Factors That May Regulate Inflammatory Response

Thomas E. Van Dyke

Kenneth S. Kornman

Journal of Periodontology Vol. 79 No. 8S pp. 1503-1507 · Wiley

View at Publisher Save 10.1902/jop.2008.080239

Abstract

The concept of inflammation has a long history. Although an inflammatory response to injury or another trigger is necessary, chronic diseases, such as coronary heart disease and diabetes, may develop because of unchecked inflammatory responses that have maladapted over decades. For example, the earliest changes in atherosclerosis occur in the endothelium, leading to a cascade of inflammatory responses, such as accumulation of monocytes and T cells, migration of leukocytes into the intima, monocyte differentiation and proliferation, and lesion and fibrous cap development. Inflammatory markers, such as C‐reactive protein, may allow clinical insight into these decades‐long processes, adding value to predictive measures of disease outcomes. Anti‐inflammatory factors, such as adiponectin, may provide further understanding of the inflammatory pathways involved. Greater understanding of the complex pathways involved in inflammation may provide alternative therapeutic strategies to combat inflammation and chronic diseases potentially arising from it.

Topics

No keywords indexed for this article. Browse by subject →

References

41

[1]

Cotran R (1999)

[2]

10.1056/nejm200008033430506

[3]

Innate Immune Recognition

Charles A. Janeway, Ruslan Medzhitov

Annual Review of Immunology 10.1146/annurev.immunol.20.083001.084359

[4]

10.1161/01.res.0000029784.15893.10

[5]

10.1056/nejm199901143400207

[6]

Inflammation and Atherosclerosis

Peter Libby, Paul M. Ridker, Attilio Maseri

Circulation 10.1161/hc0902.104353

[7]

10.1161/01.atv.13.2.197

[8]

10.1172/jci11871

[9]

10.1016/s0065-2776(08)60509-x

[10]

Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3

E A Garcia-Zepeda, C Combadiere, M E Rothenberg et al.

The Journal of Immunology 1996 10.4049/jimmunol.157.12.5613

[11]

10.1038/nm0496-449

[12]

10.1016/s1097-2765(00)80139-2

[13]

10.1038/29788

[14]

10.1172/jci115411

[15]

10.1172/jci6993

[16]

10.1161/01.cir.91.11.2844

[17]

10.1016/s0140-6736(89)90953-7

[18]

10.1161/01.res.71.4.850

[19]

10.1161/01.atv.11.5.1223

[20]

10.1016/s0140-6736(96)07591-5

[21]

10.1056/nejm199408183310701

[22]

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

Paul M. Ridker, Mary Cushman, Meir J. Stampfer et al.

New England Journal of Medicine 10.1056/nejm199704033361401

[23]

10.1161/01.cir.103.9.1194

[24]

10.1161/01.cir.99.2.237

[25]

C-Reactive Protein Adds to the Predictive Value of Total and HDL Cholesterol in Determining Risk of First Myocardial Infarction

Paul M. Ridker, Robert J. Glynn, Charles H. Hennekens

Circulation 10.1161/01.cir.97.20.2007

[26]

10.1007/s001250050822

[27]

10.1161/01.atv.19.4.972

[28]

10.1161/01.cir.102.1.42

[29]

10.1046/j.1365-2796.1999.00490.x

[30]

10.1038/nm0796-800

[31]

10.1038/35053000

[32]

10.1006/bbrc.1996.0587

[33]

10.2337/diacare.26.8.2442

[34]

10.1161/01.atv.20.6.1595

[35]

10.1210/jcem.86.5.7463

[36]

10.2337/diabetes.50.9.2094

[37]

10.1053/meta.2002.30506

[38]

10.2337/diacare.25.2.376

[39]

10.1210/endo.143.3.8662

[40]

10.1016/j.amjcard.2007.07.041

[41]

10.1155/2007/93573

Cited By

66

Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest

Monica Colitti, Bruno Stefanon · 2019

Antioxidants

Metrics

66

Citations

41

References

Details

Published: Aug 01, 2008
Vol/Issue: 79(8S)
Pages: 1503-1507
License: View

Authors

T

Thomas E. Van Dyke

Center for Clinical and Translational Research, ADA Forsyth Institute, Cambridge, Massachusetts, USA; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA

K

Kenneth S. Kornman

Cite This Article

Thomas E. Van Dyke, Kenneth S. Kornman (2008). Inflammation and Factors That May Regulate Inflammatory Response. Journal of Periodontology, 79(8S), 1503-1507. https://doi.org/10.1902/jop.2008.080239

Inflammation and Factors That May Regulate Inflammatory Response

You May Also Like