Hyaluronic Acid as an Adjunct After Scaling and Root Planing: A Prospective Randomized Clinical Trial

Sigrun Eick; Antonio Renatus; Melanie Heinicke; Wolfgang Pfister; Stefan‐Ioan Stratul; Holger Jentsch

doi:10.1902/jop.2012.120269

journal article Jul 01, 2013

Hyaluronic Acid as an Adjunct After Scaling and Root Planing: A Prospective Randomized Clinical Trial

Sigrun Eick Antonio Renatus Melanie Heinicke Wolfgang Pfister Stefan‐Ioan Stratul Holger Jentsch

Journal of Periodontology Vol. 84 No. 7 pp. 941-949 · Wiley

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Abstract

Background: The study is designed to determine the effect on clinical variables, subgingival bacteria, and local immune response brought about by application of hyaluronan‐containing gels in early wound healing after scaling and root planing (SRP).Methods: In this randomized clinical study, data from 34 individuals with chronic periodontitis were evaluated after full‐mouth SRP. In the test group (n = 17), hyaluronan gels in two molecular weights were additionally applied during the first 2 weeks after SRP. The control group (n = 17) was treated with SRP only. Probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and after 3 and 6 months, and subgingival plaque and sulcus fluid samples were taken for microbiologic and biochemical analysis.Results: In both groups, PD and CAL were significantly reduced (P <0.001). The changes in PD and the reduction of the number of pockets with PD ≥5 mm were significantly higher in the test group after 3 (P = 0.014 and 0.021) and 6 (P = 0.046 and 0.045) months. Six months after SRP, the counts of Treponema denticola were significantly reduced in both groups (both P = 0.043), as were those of Campylobacter rectus in the test group only (P = 0.028). Prevotella intermedia and Porphyromonas gingivalis increased in the control group.Conclusion: The adjunctive application of hyaluronan may have positive effects on PD reduction and may prevent recolonization by periodontopathogens.

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Published: Jul 01, 2013
Vol/Issue: 84(7)
Pages: 941-949
License: View

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Cite This Article

Sigrun Eick, Antonio Renatus, Melanie Heinicke, et al. (2013). Hyaluronic Acid as an Adjunct After Scaling and Root Planing: A Prospective Randomized Clinical Trial. Journal of Periodontology, 84(7), 941-949. https://doi.org/10.1902/jop.2012.120269

Hyaluronic Acid as an Adjunct After Scaling and Root Planing: A Prospective Randomized Clinical Trial

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