Risk of Non-cutaneous Cancers in Individuals with Basal Cell Carcinoma: A Population-based Cohort Study

Hanna Kuru; Jari Jokelainen; Kaisa Tasanen; Laura Huilaja

doi:10.2340/actadv.v102.4451

journal article Open Access Nov 30, 2022

Risk of Non-cutaneous Cancers in Individuals with Basal Cell Carcinoma: A Population-based Cohort Study

Hanna Kuru Jari Jokelainen

Kaisa Tasanen

Laura Huilaja

Acta Dermato-Venereologica Vol. 102 pp. adv00826 · Medical Journals Sweden AB

View at Publisher Save 10.2340/actadv.v102.4451

Abstract

Evidence of the association between a personal history of basal cell carcinoma and the risk of non-cutaneous malignancies is conflicting. The aim of this study was to retrospectively clarify the risk of non-cutaneous cancers in individuals with basal cell carcinoma using nationwide Finnish registry data for 96,304 patients and 394,503 randomly selected population controls. In this study, individuals with basal cell carcinoma have an increased risk of other cancers (odds ratio (OR) 1.38; 95% confidence interval (95% CI) 1.36–1.40). The risk was most prominent for lip cancer (OR 5.29; 95% CI 4.50–6.21), mycosis fungoides (OR 3.13; 95% CI 2.31–4.23) and soft tissue cancers (OR 2.77; 95% CI 2.43–3.16). In age-adjusted model, men had higher risk of cancers overall compared with women (p < 0.05). In conclusion, the study found increased overall cancer risk among patients with basal cell carcinoma compared with randomly selected population controls.

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Details

Published: Nov 30, 2022
Vol/Issue: 102
Pages: adv00826
License: View

Authors

Northern Finland Birth Cohorts, Arctic Biobank and Infrastructure for Population Studies, University of Oulu , Oulu ,

K

Kaisa Tasanen

Department of Dermatology, University Hospital of Oulu, Oulu, Finland and Medical Research Center, Research Group of Clinical Medicine, University of Oulu , Oulu , Finland

L

Laura Huilaja

Department of Dermatology, University Hospital of Oulu, Oulu, Finland and Medical Research Center, Research Group of Clinical Medicine, University of Oulu , Oulu , Finland

Cite This Article

Hanna Kuru, Jari Jokelainen, Kaisa Tasanen, et al. (2022). Risk of Non-cutaneous Cancers in Individuals with Basal Cell Carcinoma: A Population-based Cohort Study. Acta Dermato-Venereologica, 102, adv00826. https://doi.org/10.2340/actadv.v102.4451

Risk of Non-cutaneous Cancers in Individuals with Basal Cell Carcinoma: A Population-based Cohort Study

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