Mineralization and Biocompatibility of Antheraea pernyi (A. pernyi) Silk Sericin Film for Potential Bone Tissue Engineering

Mingying Yang; Namita Mandal; Yajun Shuai; Guanshan Zhou; Sijia Min; Liangjun Zhu

doi:10.3233/bme-130873

journal article Jan 01, 2014

Mineralization and Biocompatibility of Antheraea pernyi (A. pernyi) Silk Sericin Film for Potential Bone Tissue Engineering

Mingying Yang

Namita Mandal Yajun Shuai

Guanshan Zhou Sijia Min Liangjun Zhu

Bio-Medical Materials and Engineering Vol. 24 No. 1 pp. 815-824 · SAGE Publications

View at Publisher Save 10.3233/bme-130873

Abstract

This study aimed to investigate the mineralization of Antheraea pernyi (A. pernyi) silk sericin. Mineralization of A. pernyi sericin was performed by alternative soaking in calcium and phosphate. The inhibition of precipitation of calcium carbonate and von Kossa staining on A. pernyi sericin were tested, and the corresponding results prove that A. pernyi sericin has Ca binding activity. Scanning electron microscope (SEM) observation shows that spherical crystals could be nucleated on the A. pernyi sericin film. These crystals were confirmed to be hydroxyapatite according to FT-IR and XRD spectra, indicating that A. pernyi sericin is capable of mineralization. In addition, cell adhesion and growth activity assay demonstrate that A. pernyi sericin shows excellent biocompatibility for the growth of MG-63 cells.

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Published: Jan 01, 2014
Vol/Issue: 24(1)
Pages: 815-824
License: View

Authors

M

Mingying Yang