Prodromal Alzheimer’s Disease Demonstrates Increased Errors at a Simple and Automated Anti-Saccade Task

John G. Holden; Alexandre Cosnard; Brice Laurens; Julien Asselineau; Damien Biotti; Stéphanie Cubizolle; Sandrine Dupouy; Maıté Formaglio; Lejla Koric; Magali Seassau; Caroline Tilikete; Alain Vighetto; François Tison

doi:10.3233/jad-180082

journal article Aug 21, 2018

Prodromal Alzheimer’s Disease Demonstrates Increased Errors at a Simple and Automated Anti-Saccade Task

John G. Holden Alexandre Cosnard Brice Laurens Julien Asselineau Damien Biotti

Stéphanie Cubizolle Sandrine Dupouy Maıté Formaglio Lejla Koric Magali Seassau Caroline Tilikete Alain Vighetto François Tison

Journal of Alzheimer’s Disease Vol. 65 No. 4 pp. 1209-1223 · SAGE Publications

View at Publisher Save 10.3233/jad-180082

Abstract

Saccade alterations are potential early signs of Alzheimer’s disease. However, uncertainty persists in how early and reliably automated saccade recording systems detect impairments. This multicenter pathophysiological case-control transversal study explored saccade execution in carefully diagnosed amnestic mild cognitive impairment patients fulfilling research criteria for prodromal Alzheimer’s disease ( n = 29), as compared to both aged-matched mild Alzheimer’s disease patients ( n = 23) and controls ( n = 27). Auto-coded saccades from horizontal (gap) vertical (step) stimulus elicited pro-saccades, and anti-saccade (gap) tasks were compared across the 3 groups. Mild cognitive impairment patients committed significantly more anti-saccade errors compared to controls (46.9 versus 24.3%, p < 0.001). Conventional analyses of the auto-coded stimulus elicited saccades parameters did not distinguish the amnestic mild cognitive impairment from controls or the mild Alzheimer’s disease group. However, an offline analysis of manually coded saccade latencies, using resampling statistics did reveal subtle differences among the groups. Analysis of the manually coded data revealed that the mild Alzheimer’s disease group had a reliably larger self-corrected error-rate than in amnestic mild cognitive impairment and controls ( p = 0.003). Analysis of the manually coded saccade latencies, using more sensitive lognormal bootstrap analysis revealed a continuum, from amnestic mild cognitive impairment to mild Alzheimer’s disease, of an increased severity of impaired inhibition of stimulus elicited saccades and correct voluntary saccade initiation. Anti-saccade error rates and psychometric measures of executive and several other cognitive functions were moderately and negatively correlated. Overall, inhibitory impairments in stimulus elicited saccades, characteristic of Alzheimer’s disease, may be detected early in presumed prodromal patients using a simple, automated anti-saccade task.

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Details

Published: Aug 21, 2018
Vol/Issue: 65(4)
Pages: 1209-1223
License: View

Authors

J

John G. Holden

Institute for Neurodegenerative Diseases, Clinical Branch, University and University Hospital of Bordeaux, Bordeaux, France; Department of Psychology, University of Cincinnati, OH, USA

A

Alexandre Cosnard

Institute for Neurodegenerative Diseases, Clinical Branch, University and University Hospital of Bordeaux, Bordeaux, France

B

Brice Laurens

Institute for Neurodegenerative Diseases, Clinical Branch, University and University Hospital of Bordeaux, Bordeaux, France

J

Julien Asselineau

Department of Public Health Bordeaux University Hospital, Clinical Epidemiology Unit, Bordeaux, France

D

Damien Biotti

Department of Neurocognition, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France

S

Stéphanie Cubizolle

Institute for Neurodegenerative Diseases, Clinical Branch, University and University Hospital of Bordeaux, Bordeaux, France

S

Sandrine Dupouy

Institute for Neurodegenerative Diseases, Clinical Branch, University and University Hospital of Bordeaux, Bordeaux, France

M

Maıté Formaglio

Department of Neurocognition, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France

L

Lejla Koric

Department of Neurology and Neuropsychology University Hospital la Timone, Marseille, France

M

Magali Seassau

e(ye)BRAIN, Ivry-sur-Seine, France

C

Caroline Tilikete

Department of Neurocognition, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France

A

Alain Vighetto

Department of Neurocognition, Hôpital Neurologique et Neurochirurgical Pierre Wertheimer, Lyon, France

F

François Tison

Institute for Neurodegenerative Diseases, Clinical Branch, University and University Hospital of Bordeaux, Bordeaux, France

Cite This Article

John G. Holden, Alexandre Cosnard, Brice Laurens, et al. (2018). Prodromal Alzheimer’s Disease Demonstrates Increased Errors at a Simple and Automated Anti-Saccade Task. Journal of Alzheimer’s Disease, 65(4), 1209-1223. https://doi.org/10.3233/jad-180082

Prodromal Alzheimer’s Disease Demonstrates Increased Errors at a Simple and Automated Anti-Saccade Task

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