Subjective Cognitive Decline Is Associated with Health-Related Quality of Life in the Middle-Aged to Elderly Population

Alina Königsberg; Matthias H. Belau; Leonie Ascone; Jürgen Gallinat; Simone Kühn; Märit Jensen; Christian Gerloff; Bastian Cheng; Götz Thomalla

doi:10.3233/jad-220659

journal article Jan 03, 2023

Subjective Cognitive Decline Is Associated with Health-Related Quality of Life in the Middle-Aged to Elderly Population

Alina Königsberg Matthias H. Belau Leonie Ascone Jürgen Gallinat Simone Kühn

Märit Jensen Christian Gerloff Bastian Cheng Götz Thomalla

Journal of Alzheimer’s Disease Vol. 91 No. 1 pp. 427-436 · SAGE Publications

View at Publisher Save 10.3233/jad-220659

Abstract

Background: Subjective cognitive decline (SCD) is considered to be a preliminary stage of dementia, and its prevalence is increasing with age. Objective: We aimed to study the association of SCD with health-related quality of life (HRQoL) in a large population-based sample. Methods: We analyzed data of the first 10,000 participants from the Hamburg City Health Study in Germany, a single center prospective cohort study, aged between 45 and 74 years that scored higher than 25 points in the Mini-Mental State Examination and had no known pre-existing dementia. HRQoL was assessed by the EQ-5D-5 L index, as well as the mental (MCS) and physical component summary (PCS) score of the Short Form-8. We computed linear regression analyses with 99% bias-corrected and accelerated (BCa) confidence intervals (CI) from 10,000 bootstrap samples to investigate the association between SCD and different indicators of HRQoL, while controlling for depression (PHQ-9), age, sex, and education as potential confounders. Results: Of 7,799 eligible participants (mean (SD) age 62.01 (8.41) years, 51.1% female), 3,708 (47.5%) reported SCD. Participants with SCD were older (62.7 versus 61.4 years) and more frequently female (54.2% versus 48.2%). SCD was independently associated with a lower EQ-5D-5 L index (β=–0.01, 99% BCa CI = [–0.020, –0.003], p < 0.001) and PCS (β=–1.00, 99% BCa CI = [–1.48, –0.51], p < 0.001) but not with MCS score. Conclusion: In a population of middle-aged to elderly participants, there is a significant negative association between SCD and HRQoL across different instruments of HRQoL measurement independent of depression, demographics, and education.

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Citations

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References

Details

Published: Jan 03, 2023
Vol/Issue: 91(1)
Pages: 427-436

Authors

A

Alina Königsberg

Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

M

Matthias H. Belau

Institut für Medizinische Biometrie und Epidemiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

L

Leonie Ascone

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Hamburg, Germany

J

Jürgen Gallinat

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Hamburg, Germany

S

Simone Kühn

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Hamburg, Germany

M

Märit Jensen

Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

C

Christian Gerloff

Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

B

Bastian Cheng

Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

G

Götz Thomalla

Klinik und Poliklinik für Neurologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Cite This Article

Alina Königsberg, Matthias H. Belau, Leonie Ascone, et al. (2023). Subjective Cognitive Decline Is Associated with Health-Related Quality of Life in the Middle-Aged to Elderly Population. Journal of Alzheimer’s Disease, 91(1), 427-436. https://doi.org/10.3233/jad-220659

Subjective Cognitive Decline Is Associated with Health-Related Quality of Life in the Middle-Aged to Elderly Population

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