Association Between Hippocampal Volume and African Neuropsychology Memory Tests in Adult Individuals with Probable Alzheimer’s Disease in Democratic Republic of Congo

Jean Ikanga; Sabrina Hickle; Megan Schwinne; Emmanuel Epenge; Guy Gikelekele; Immaculee Kavugho; Nathan Tsengele; Mampunza Samuel; Liping Zhao; Deqiang Qiu; Anthony Stringer; Amit M. Saindane; Alvaro Alonso; Daniel L. Drane

doi:10.3233/jad-230206

journal article Sep 28, 2023

Association Between Hippocampal Volume and African Neuropsychology Memory Tests in Adult Individuals with Probable Alzheimer’s Disease in Democratic Republic of Congo

Jean Ikanga Sabrina Hickle Megan Schwinne Emmanuel Epenge Guy Gikelekele Immaculee Kavugho Nathan Tsengele Mampunza Samuel Liping Zhao

Deqiang Qiu

Anthony Stringer Amit M. Saindane Alvaro Alonso Daniel L. Drane

Journal of Alzheimer’s Disease Vol. 96 No. 1 pp. 395-408 · SAGE Publications

View at Publisher Save 10.3233/jad-230206

Abstract

Background: Western studies indicate potential associations between hippocampal volume and memory in the trajectory of Alzheimer’s disease (AD). However, limited availability of neuroimaging technology and neuropsychological tests appropriate for sub-Saharan African (SSA) countries makes it difficult to establish neuroanatomical associations of hippocampus and memory in this locale. Objective: This study examined hippocampal volumes and memory in healthy control (HC) and probable AD groups in the Democratic Republic of Congo (DRC). Methods: Forty-six subjects with probable AD and 29 HC subjects were screened using the Community Instrument for Dementia and the Alzheimer Questionnaire. Participants underwent neuroimaging in Kinshasa, DRC, and memory was evaluated using the African Neuropsychology Battery (ANB). Multiple linear regression was used to determine associations between hippocampal volumes and memory. Results: Patients with probable AD performed significantly worse than HCs on ANB memory measures, and exhibited greater cerebral atrophy, which was significantly pronounced in the medial temporal lobe region (hippocampus, entorhinal cortex). Both AD and HC subjects exhibited high rates of white matter hyperintensities compared to international base rate prevalence, which was significantly worse for probable AD. Both also exhibited elevated rates of microhemorrhages. Regression analysis demonstrated a significant association between hippocampal volume and ANB memory tests. Hippocampal atrophy discriminated probable AD from the HC group. Conclusions: This study establishes the feasibility of conducting neuroimaging research in the SSA, demonstrates many known neuroimaging findings in probable AD patients hold up using culturally appropriate memory tasks, and suggest cardiovascular problems are a greater issue in SSA than in Western countries.

Topics

No keywords indexed for this article. Browse by subject →

References

49

[1]

10.3402/gha.v6i0.19646

[2]

Ikanga J 48th Annual Meeting of the International Neuropsychological Society (2020)

[3]

10.1002/1099-1166(200006)15:6<521::aid-gps182>3.0.co;2-f

[4]

10.1159/000320247

[5]

Visser PJ J Neurol Neurosurg Psychiatry (2002)

[6]

10.1212/01.wnl.0000044400.11317.ec

[7]

10.1177/0956797620916782

[8]

10.1016/j.pscychresns.2015.08.014

[9]

Csernansky JG Alzheimer Dis Assoc Disord (2004)

[10]

10.1186/s13195-015-0147-9

[11]

10.1136/jnnp.58.5.590

[12]

10.1176/jnp.23.1.jnp6

[13]

10.3233/jad-180328

[14]

10.1212/01.wnl.0000336925.79704.9f

[15]

10.1101/cshperspect.a006213

[16]

10.1136/jnnp-2014-310095

[17]

10.1016/j.neurobiolaging.2006.03.007

[18]

10.1016/j.jalz.2018.07.221

[19]

10.1155/2014/908915

[20]

10.3389/fnagi.2022.937486

[21]

10.3233/jad-2011-111364

[22]

10.3389/fneur.2021.627761

[23]

10.1016/j.jalz.2015.05.002

[24]

10.1093/arclin/acz035.26

[25]

10.1093/arclin/acac003

[26]

10.1016/s0140-6736(03)12772-9

[27]

10.3233/jad-179920

[28]

10.3233/jad-2010-101185

[29]

10.1300/j018v05n01_09

[30]

Zhang C BMC Geriatrics (2022) 10.1186/s12877-021-02658-0

[31]

10.1161/01.str.32.6.1318

[32]

10.1007/s00330-016-4726-3

[33]

10.1148/radiol.2018171888

[34]

10.1016/j.tins.2017.12.006

[35]

10.3389/fpsyt.2021.718539

[36]

10.1001/archneurol.2009.252

[37]

10.1161/01.str.0000199847.96188.12

[38]

MRI evidence of past cerebral microbleeds in a healthy elderly population

G. Roob, R. Schmidt, P. Kapeller et al.

Neurology 10.1212/wnl.52.5.991

[39]

10.1093/brain/awq321

[40]

10.1002/nbm.4846

[41]

10.1016/j.cardfail.2018.10.008

[42]

Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective

Matthew Fomonyuy Yuyun, Karen Sliwa, Andre Pascal Kengne et al.

Global Heart 10.5334/gh.403

[43]

10.1016/j.neuroimage.2008.10.043

[44]

Vascular Contributions to Cognitive Impairment and Dementia

Philip B. Gorelick, Angelo Scuteri, Sandra E. Black et al.

Stroke 10.1161/str.0b013e3182299496

[45]

10.3390/jcm8020167

[46]

10.3233/adr-170013

[47]

10.1016/j.neuroimage.2010.09.005

[48]

10.1007/s00406-012-0350-7

[49]

10.1006/nimg.2002.1248

Metrics

7

Citations

49

References

Details

Published: Sep 28, 2023
Vol/Issue: 96(1)
Pages: 395-408
License: View

Authors

J

Jean Ikanga

Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA; Department of Psychiatry, University of Kinshasa and Catholic University of Congo, School of Medicine, Kinshasa, Kinshasa I, Democratic Republic of Congo

S

Sabrina Hickle

Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA

M

Megan Schwinne

Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA, USA

E

Emmanuel Epenge

Department of Neurology, University of Kinshasa, Kinshasa, Kinshasa I, Democratic Republic of Congo

G

Guy Gikelekele

Department of Psychiatry, University of Kinshasa and Catholic University of Congo, School of Medicine, Kinshasa, Kinshasa I, Democratic Republic of Congo

I

Immaculee Kavugho

Memory Clinic of Kinshasa, Kinshasa, Kinshasa I, Democratic Republic of Congo

N

Nathan Tsengele

Department of Psychiatry, University of Kinshasa and Catholic University of Congo, School of Medicine, Kinshasa, Kinshasa I, Democratic Republic of Congo; Faculty of Medicine, University of Kikwit, Kinshasa, Democratic Republic of Congo

M

Mampunza Samuel

Department of Psychiatry, University of Kinshasa and Catholic University of Congo, School of Medicine, Kinshasa, Kinshasa I, Democratic Republic of Congo

L

Liping Zhao

Department of Biostatistics and Bioinformatics, Emory University, Rollins School of Public Health, Atlanta, GA, USA

D

Deqiang Qiu

Department of Radiology and Imaging Sciences & Department of Biomedical Engineering, Emory University, School of Medicine, Atlanta, GA, USA

A

Anthony Stringer

Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA

A

Amit M. Saindane

Departments of Radiology and Imaging Sciences and Neurosurgery, Emory University, School of Medicine, Atlanta, GA, USA

A

Alvaro Alonso

Department of Epidemiology, Emory University, Rollins School of Public Health, Atlanta, GA, USA

D

Daniel L. Drane

Departments of Neurology and Pediatrics, Emory University, School of Medicine, Atlanta, GA, USA

Cite This Article

Jean Ikanga, Sabrina Hickle, Megan Schwinne, et al. (2023). Association Between Hippocampal Volume and African Neuropsychology Memory Tests in Adult Individuals with Probable Alzheimer’s Disease in Democratic Republic of Congo. Journal of Alzheimer’s Disease, 96(1), 395-408. https://doi.org/10.3233/jad-230206

Association Between Hippocampal Volume and African Neuropsychology Memory Tests in Adult Individuals with Probable Alzheimer’s Disease in Democratic Republic of Congo

You May Also Like