Single nucleotide polymorphisms in binding site of miRNA-135a and targeted gene IRS2 are correlated with multiple clinical features of PCOS: A study in Chinese women

Heng Gu; Bingyi Zhou; Wenyao Zhong; Xiangcai Wei; Xingmin Zhong

doi:10.3233/thc-228007

journal article Open Access Mar 02, 2022

Single nucleotide polymorphisms in binding site of miRNA-135a and targeted gene IRS2 are correlated with multiple clinical features of PCOS: A study in Chinese women

Heng Gu

Bingyi Zhou Wenyao Zhong Xiangcai Wei Xingmin Zhong

Technology and Health Care Vol. 30 pp. 71-80 · SAGE Publications

View at Publisher Save 10.3233/thc-228007

Abstract

BACKGROUND: The etiology of polycystic ovary syndrome (PCOS) remains unclear with highly heterogeneous clinical manifestations, recently growing evidence revealing genetic variants play a crucial part in its pathogenesis. OBJECTIVE: This study aimed to examine the correlation between SNPs in miRNA-135a’s binding site of targeted gene IRS2 and clinical manifestations of PCOS in Chinese females. METHOD: A total of 126 Chinese women with PCOS and 109 healthy women were enrolled, divided into 4 groups based on different clinical features of hyperandrogenemia (HA), insulin resistance (IR), polycystic ovary morphology (PCOM) and obesity. We analyzed 2 single nucleotide polymorphisms (SNPs) of the IRS2 gene (rs2289046 and rs1865434) and clinical features’ laboratory measurements such as sex hormone, fasting plasma glucose (FPG), fasting plasma insulin (FINS). RESULTS: Located in miRNA-135a binding site of IRS2 gene, the rs2289046’s triple genotypes distribution showed a significant difference between PCOS/control group and PCOM/non-PCOM group (P< 0.05) while the rs1865434’s triple genotype distribution showed a significant difference between obesity/non-obesity group (P< 0.05). CONCLUSION: The results revealed the two SNPs as rs2289046 and rs1865434 in the IRS-2 binding region of miRNA-135a have correlations with the clinical features of PCOS in Chinese population.

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Details

Published: Mar 02, 2022
Vol/Issue: 30
Pages: 71-80
License: View

Authors

H

Heng Gu

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Hospital, Guangzhou, Guangdong, China; NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Hospital, Guangzhou, Guangdong, China

B

Bingyi Zhou

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Hospital, Guangzhou, Guangdong, China

W

Wenyao Zhong

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Hospital, Guangzhou, Guangdong, China

X

Xiangcai Wei

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Hospital, Guangzhou, Guangdong, China; Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

X

Xingmin Zhong

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Hospital, Guangzhou, Guangdong, China; Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, Guangdong, China

Cite This Article

Heng Gu, Bingyi Zhou, Wenyao Zhong, et al. (2022). Single nucleotide polymorphisms in binding site of miRNA-135a and targeted gene IRS2 are correlated with multiple clinical features of PCOS: A study in Chinese women. Technology and Health Care, 30, 71-80. https://doi.org/10.3233/thc-228007

Single nucleotide polymorphisms in binding site of miRNA-135a and targeted gene IRS2 are correlated with multiple clinical features of PCOS: A study in Chinese women

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