Current treatment and recent progress in gastric cancer
Gastric cancer is not a top‐10 malignancy in the United States but represents one of the most common causes of cancer death worldwide. Biological differences between tumors from Eastern and Western countries add to the complexity of identifying standard‐of‐care therapy based on international trials. Systemic chemotherapy, radiotherapy, surgery, immunotherapy, and targeted therapy all have proven efficacy in gastric adenocarcinoma; therefore, multidisciplinary treatment is paramount to treatment selection. Triplet chemotherapy for resectable gastric cancer is now accepted and could represent a plateau of standard cytotoxic chemotherapy for localized disease. Classification of gastric cancer based on molecular subtypes is providing an opportunity for personalized therapy. Biomarkers, in particular microsatellite instability (MSI), programmed cell death ligand 1 (PD‐L1), human epidermal growth factor receptor 2 (HER2), tumor mutation burden, and Epstein‐Barr virus, are increasingly driving systemic therapy approaches and allowing for the identification of populations most likely to benefit from immunotherapy and targeted therapy. Significant research opportunities remain for the less differentiated histologic subtypes of gastric adenocarcinoma and those without markers of immunotherapy activity.
No keywords indexed for this article. Browse by subject →
Naruhiko Ikoma, Mariela Blum, Yi-Ju Chiang et al.
David Cunningham, William H. Allum, Sally P. Stenning et al.
Marc Ychou, Valerie Boige, Jean-Pierre Pignon et al.
Salah-Eddin Al-Batran, Nils Homann, Claudia Pauligk et al.
Yung-Jue Bang, Young-Woo Kim, Han-Kwang Yang et al.
Kazuhiro Yoshida, Yasuhiro Kodera, Mitsugu Kochi et al.
P. van Hagen, M.C.C.M. Hulshof, J.J.B. van Lanschot et al.
Showing 50 of 98 references
- Published
- Feb 16, 2021
- Vol/Issue
- 71(3)
- Pages
- 264-279
- License
- View
You May Also Like
Hyuna Sung, Jacques Ferlay · 2021
76,840 citations
Freddie Bray, Jacques Ferlay · 2018
53,435 citations
Freddie Bray, Mathieu Laversanne · 2024
16,936 citations