Time course of recovery of different motor functions following a reproducible cortical infarction in non-human primates

Akito Kosugi; Yosuke Saga; Moeko Kudo; Masashi Koizumi; Tatsuya Umeda; Kazuhiko Seki

doi:10.3389/fneur.2023.1094774

journal article Open Access Feb 09, 2023

Time course of recovery of different motor functions following a reproducible cortical infarction in non-human primates

Akito Kosugi Yosuke Saga Moeko Kudo Masashi Koizumi Tatsuya Umeda Kazuhiko Seki

Frontiers in Neurology Vol. 14 · Frontiers Media SA

View at Publisher Save 10.3389/fneur.2023.1094774

Abstract

A major challenge in human stroke research is interpatient variability in the extent of sensorimotor deficits and determining the time course of recovery following stroke. Although the relationship between the extent of the lesion and the degree of sensorimotor deficits is well established, the factors determining the speed of recovery remain uncertain. To test these experimentally, we created a cortical lesion over the motor cortex using a reproducible approach in four common marmosets, and characterized the time course of recovery by systematically applying several behavioral tests before and up to 8 weeks after creation of the lesion. Evaluation of in-cage behavior and reach-to-grasp movement revealed consistent motor impairments across the animals. In particular, performance in reaching and grasping movements continued to deteriorate until 4 weeks after creation of the lesion. We also found consistent time courses of recovery across animals for in-cage and grasping movements. For example, in all animals, the score for in-cage behaviors showed full recovery at 3 weeks after creation of the lesion, and the performance of grasping movement partially recovered from 4 to 8 weeks. In addition, we observed longer time courses of recovery for reaching movement, which may rely more on cortically initiated control in this species. These results suggest that different recovery speeds for each movement could be influenced by what extent the cortical control is required to properly execute each movement.

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Published: Feb 09, 2023
Vol/Issue: 14
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Authors

Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan; Research Center for Materials Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan

Cite This Article

Akito Kosugi, Yosuke Saga, Moeko Kudo, et al. (2023). Time course of recovery of different motor functions following a reproducible cortical infarction in non-human primates. Frontiers in Neurology, 14. https://doi.org/10.3389/fneur.2023.1094774

Time course of recovery of different motor functions following a reproducible cortical infarction in non-human primates

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