Mechanical Stretch Induces Smooth Muscle Cell Dysfunction by Regulating ACE2 via P38/ATF3 and Post-transcriptional Regulation by miR-421

Xinxin Liu; Mengmeng Li; Yu Zhang; Weijia Chen; Meng Zhang; Cheng Zhang; Mei Zhang

doi:10.3389/fphys.2020.540591

journal article Open Access Jan 18, 2021

Mechanical Stretch Induces Smooth Muscle Cell Dysfunction by Regulating ACE2 via P38/ATF3 and Post-transcriptional Regulation by miR-421

Xinxin Liu

Frontiers in Physiology Vol. 11 · Frontiers Media SA

View at Publisher Save 10.3389/fphys.2020.540591

Abstract

Graphical AbstractMechanical stretch may decrease the level of the protective factor ACE2 via the p38 MAPK/ATF3 pathway by prompting ATF3 translocation into the nucleus, which could directly bind to the ACE2 promoter via post-transcriptional regulation by miR-421.

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Details

Published: Jan 18, 2021
Vol/Issue: 11
License: View

Authors

Howard Hughes Medical Institute, Waksman Institute, and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.

W

Weijia Chen

South China Normal University

Liaoning University

Xiamen University

Cite This Article

Xinxin Liu, Mengmeng Li, Yu Zhang, et al. (2021). Mechanical Stretch Induces Smooth Muscle Cell Dysfunction by Regulating ACE2 via P38/ATF3 and Post-transcriptional Regulation by miR-421. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.540591

Mechanical Stretch Induces Smooth Muscle Cell Dysfunction by Regulating ACE2 via P38/ATF3 and Post-transcriptional Regulation by miR-421

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