Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study

Aliénor Delsart; Colombe Otis; Vivian S. Y. Leung; Émilie Labelle; Maxim Moreau; Marilyn Frezier; Marlene Drag; Johanne Martel-Pelletier; Jean-Pierre Pelletier; Eric Troncy

doi:10.3390/ani14050711

journal article Open Access Feb 24, 2024

Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study

Aliénor Delsart

Colombe Otis

Vivian S. Y. Leung Émilie Labelle Maxim Moreau

Marilyn Frezier

Marlene Drag

Johanne Martel-Pelletier

Jean-Pierre Pelletier

Eric Troncy

Animals Vol. 14 No. 5 pp. 711 · MDPI AG

View at Publisher Save 10.3390/ani14050711

Abstract

Veterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its concurrent validation. Cats naturally affected by OA (n = 32) were randomly distributed into 4 groups of firocoxib analgesic (Gr. A: 0.40; B: 0.25; C: 0.15, and P: 0.00 mg/kg bodyweight). They were assessed during Baseline, Treatment, and Recovery periods using MI-CAT(V) and objective outcomes (effort path, stairs assay compliance, and actimetry). The MI-CAT(V) total score correlated to the effort path and actimetry (RhoS = −0.501 to −0.453; p < 0.001), also being sensitive to treatment responsiveness. The pooled treatment group improved its total, gait, and body posture scores during Treatment compared to the Baseline, Recovery, and placebo group (p < 0.05). The MI-CAT(V) suggested a dose-(especially for Gr. B) and cluster-response. Cats in the moderate and severe MI-CAT(V) clusters responded to firocoxib with a remaining analgesic effect, while the mild cluster seemed less responsive and experienced a negative rebound effect. The MI-CAT(V) was validated for its OA pain severity discriminatory abilities and sensitivity to firocoxib treatment, providing a new perspective for individualized care.

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Details

Published: Feb 24, 2024
Vol/Issue: 14(5)
Pages: 711
License: View

Authors

A

Aliénor Delsart