COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults

Background: Uncomplicated urinary tract infections (UTIs) are among the most common presentations of bacterial infections in the outpatient setting. The variation of outcomes reported in trials to assess the most effective treatment interventions for uncomplicated UTIs has meant that comparing and synthesising the outcomes across trials is challenging and limits the reliability of evidence which would otherwise inform healthcare decisions. Objective: Develop a Core Outcome Set (COS) for interventions for the treatment of uncomplicated UTIs in otherwise healthy adults. Methods: The COS development consisted of three phases: (1) A systematic review to identify outcomes reported in randomised trials and systematic reviews of randomised trials comparing the effectiveness of any interventions for the treatment of uncomplicated UTI in otherwise healthy adults; (2) Outcomes identified in the systematic review were prioritised in an online 3-round modified Delphi survey with healthcare practitioners (n = 68), researchers (n = 5), and people who have experienced or cared for someone experiencing a UTI (n = 180); (3) An online consensus meeting to determine the final COS with healthcare practitioners and policymakers (n = 9), researchers (n = 4), and people who have experienced or cared for someone experiencing a UTI (n = 7). Results: We identified a large number of outcomes. Through the use of robust consensus methods, those outcomes were reduced to a core set of six outcomes that should, at a minimum, be measured and reported in randomised trials and systematic reviews of interventions treating uncomplicated UTIs in adults.

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Details

Published: Dec 19, 2022
Vol/Issue: 11(12)
Pages: 1846
License: View

Authors

C

Claire Beecher

HRB Trials Methodology Research Network, School of Nursing and Midwifery, University of Galway, H91 TK33 Galway, Ireland; School of Nursing and Midwifery, University of Galway, H91 TK33 Galway, Ireland

S

Sinead Duane

HRB Trials Methodology Research Network, School of Nursing and Midwifery, University of Galway, H91 TK33 Galway, Ireland; Discipline of Marketing, J.E. Cairnes School of Business and Economics, University of Galway, H91 TK33 Galway, Ireland

A

Akke Vellinga

School of Public Health, Physiotherapy and Sports Science, University College Dublin, D04 V1W8 Dublin, Ireland

A

Andrew W. Murphy

Discipline of General Practice, HRB Primary Care Clinical Trial Network Ireland, College of Medicine, Nursing and Health Sciences, University of Galway, H91 TK33 Galway, Ireland; Discipline of General Practice, School of Medicine, University of Galway, H91 TK33 Galway, Ireland

M

Martin Cormican

Discipline of Bacteriology, School of Medicine, University of Galway, H91 TK33 Galway, Ireland

A

Andrew Smyth

HRB Clinical Research Facility Galway, University of Galway, H91 TK33 Galway, Ireland

P

Patricia Healy

School of Nursing and Midwifery, University of Galway, H91 TK33 Galway, Ireland

M

Michael Moore

Primary Care Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK

P

Paul Little

Primary Care Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK

C

Carmel Geoghegan

PPI Ignite, University of Galway, H91 TK33 Galway, Ireland

D

Declan Devane

HRB Trials Methodology Research Network, School of Nursing and Midwifery, University of Galway, H91 TK33 Galway, Ireland; School of Nursing and Midwifery, University of Galway, H91 TK33 Galway, Ireland; Evidence Synthesis Ireland and Cochrane Ireland, School of Nursing and Midwifery, University of Galway, H91 TK33 Galway, Ireland

Funding

Health Research Board of Ireland Award: CTN-2014-011

Cite This Article

Claire Beecher, Sinead Duane, Akke Vellinga, et al. (2022). COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults. Antibiotics, 11(12), 1846. https://doi.org/10.3390/antibiotics11121846

COSUTI: A Core Outcome Set (COS) for Interventions for the Treatment of Uncomplicated Urinary Tract Infection (UTI) in Adults

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