Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis

Amanda Vega-Núñez; Carlos Gómez-Sánchez-Lafuente; Fermin Mayoral-Cleries; Antonio Bordallo; Fernando Rodríguez de Fonseca; Juan Suárez; Jose Guzman-Parra

doi:10.3390/biomedicines10061368

journal article Open Access Jun 09, 2022

Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis

Amanda Vega-Núñez Carlos Gómez-Sánchez-Lafuente

Fermin Mayoral-Cleries

Antonio Bordallo Fernando Rodríguez de Fonseca

Juan Suárez

Jose Guzman-Parra

Biomedicines Vol. 10 No. 6 pp. 1368 · MDPI AG

View at Publisher Save 10.3390/biomedicines10061368

Abstract

Bipolar disorder (BD) is a multifactorial chronic psychiatric disease highly defined by genetic, clinical, environmental and social risk factors. The present systematic review and meta-analysis aimed to examine the relationship between inflammatory and neurotrophic factors and clinical, social and environmental factors involved in the development and the characterization of BD. Web of Science, PubMed, PsycINFO, Scopus and Science Direct were searched by two independent reviewers. The systematic review was registered in PROSPERO (CRD42020180626). A total of 51 studies with 4547 patients with a diagnosis of BD were selected for systematic review. Among them, 18 articles were included for meta-analysis. The study found some evidence of associations between BDNF and/or inflammatory factors and different stressors and functional and cognitive impairment, but limitations prevented firm conclusions. The main finding of the meta-analysis was a negative correlation between circulating levels of BDNF and depression severity score (standardized mean difference = −0.22, Confidence Interval 95% = −0.38, −0.05, p = 0.01). Evidence indicates that BDNF has a role in the depressive component of BD. However, the poor consistency found for other inflammatory mediators clearly indicates that highly controlled studies are needed to identity precise biomarkers of this disorder.

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Details

Published: Jun 09, 2022
Vol/Issue: 10(6)
Pages: 1368
License: View

Authors

A

Amanda Vega-Núñez

Instituto de Investigación Biomédica de Málaga-IBIMA, Parque Tecnológico de Andalucía, Severo Ochoa 35, 29590 Málaga, Spain; Facultad de Psicología, Campus de Teatinos, Universidad of Málaga, Andalucia Tech, 29071 Málaga, Spain; Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Plaza Hospital Civil s/n, Planta 1, Pabellón 4, 29009 Málaga, Spain

C

Carlos Gómez-Sánchez-Lafuente

Instituto de Investigación Biomédica de Málaga-IBIMA, Parque Tecnológico de Andalucía, Severo Ochoa 35, 29590 Málaga, Spain; Facultad de Psicología, Campus de Teatinos, Universidad of Málaga, Andalucia Tech, 29071 Málaga, Spain; Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Plaza Hospital Civil s/n, Planta 1, Pabellón 4, 29009 Málaga, Spain

F

Fermin Mayoral-Cleries

Instituto de Investigación Biomédica de Málaga-IBIMA, Parque Tecnológico de Andalucía, Severo Ochoa 35, 29590 Málaga, Spain; Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Plaza Hospital Civil s/n, Planta 1, Pabellón 4, 29009 Málaga, Spain

A

Antonio Bordallo

Instituto de Investigación Biomédica de Málaga-IBIMA, Parque Tecnológico de Andalucía, Severo Ochoa 35, 29590 Málaga, Spain; Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Plaza Hospital Civil s/n, Planta 1, Pabellón 4, 29009 Málaga, Spain

F

Fernando Rodríguez de Fonseca

Instituto de Investigación Biomédica de Málaga-IBIMA, Parque Tecnológico de Andalucía, Severo Ochoa 35, 29590 Málaga, Spain; Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Plaza Hospital Civil s/n, Planta 1, Pabellón 4, 29009 Málaga, Spain

J

Juan Suárez

Instituto de Investigación Biomédica de Málaga-IBIMA, Parque Tecnológico de Andalucía, Severo Ochoa 35, 29590 Málaga, Spain; Departamento de Anatomía Humana Medicina Legal e Historia de la Ciencia, Facultad de Medicina, Universidad de Málaga, Bulevar Louis Pausteur 32, 29071 Málaga, Spain

J

Jose Guzman-Parra

Instituto de Investigación Biomédica de Málaga-IBIMA, Parque Tecnológico de Andalucía, Severo Ochoa 35, 29590 Málaga, Spain; Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Plaza Hospital Civil s/n, Planta 1, Pabellón 4, 29009 Málaga, Spain

Funding

Universidad de Málaga/CBUA Award: RD21/0009/0003

Consejería de Salud y Familia, Junta de Andalucía Award: RD21/0009/0003

Andalusia Government Award: RD21/0009/0003

Cite This Article

Amanda Vega-Núñez, Carlos Gómez-Sánchez-Lafuente, Fermin Mayoral-Cleries, et al. (2022). Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis. Biomedicines, 10(6), 1368. https://doi.org/10.3390/biomedicines10061368

Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis

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